Childhood adversities and quality of sleep in adulthood: A population-based study of 26,000 Finns

Koskenvuo, Karoliina; Hublin, Christer; Partinen, Markku; Paunio, Tiina; Koskenvuo, Markku

doi:10.1016/j.sleep.2009.03.010

Cited by 117 publications

(124 citation statements)

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“…2,3 Sleep disturbances associated with these abuses can persist for years after the stressful events. [4][5][6] However, the mechanisms that underlie the longlasting vulnerability of sleep are still poorly understood. Adenosine and brain-derived neurotrophic factor (BDNF) have been proposed to participate in both regulation of sleep and depression.…”

Section: Introductionmentioning

confidence: 99%

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Sleep and Behavior in Cross-Fostering Rats: Developmental and Sex Aspects

Santangeli

Lehtikuja

Palomäki

et al. 2016

Sleep

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Study Objective: Adverse early-life events induce behavioral psychopathologies and sleep changes in adulthood. In order to understand the molecular level mechanisms by which the maltreatment modifies sleep, valid animal models are needed. Changing pups between mothers at early age (cross-fostering) may satisfyingly model adverse events in human childhood. Methods: Cross-fostering (CF) was used to model mild early-life stress in male and female Wistar rats. Behavior and BDNF gene expression in the basal forebrain (BF), cortex, and hypothalamus were assessed during adolescence and adulthood. Spontaneous sleep, sleep homeostasis, and BF extracellular adenosine levels were assessed in adulthood. Results: CF rats demonstrated increased number of REM sleep onsets in light and dark periods of the day. Total REM and NREM sleep duration was also increased during the light period. While sleep homeostasis was not severely affected, basal level of adenosine in the BF of both male and female CF rats was lower than in controls. CF did not lead to considerable changes in behavior. Conclusions: Even when the consequences of adverse early-life events are not observed in tests for anxiety and depression, they leave a molecular mark in the brain, which can act as a vulnerability factor for psychopathologies in later life. Sleep is a sensitive indicator for even mild early-life stress.

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Section: Introductionmentioning

confidence: 99%

“…Early-life stress affects sleep also in humans [4][5][6] : high stress load during childhood decreases sleep efficiency and increases nocturnal activity. 4,38 Most human studies on the effects of adverse childhood experiences on sleep have been obtained from self-reported and/or actigraphy data, and do not contain polysomnographic studies.…”

mentioning

confidence: 99%

Sleep and Behavior in Cross-Fostering Rats: Developmental and Sex Aspects

Santangeli

Lehtikuja

Palomäki

et al. 2016

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“…Sleep problems have been studied extensively and have been found to be associated with many physical and mental health problems, including impaired decision making [3,7], increased absenteeism and loss of productivity [8,9], decreased quality of life [4], poor physical health [10], depression and anxiety [11,12], risky health-related behaviors, such as heavy alcohol consumption and cigarette smoking [6,13,14], and suicide-related behaviors [11,15,16]. Studies have also found high rates of obesity and weight gain among individuals with troubled sleep [14,[17][18][19][20].…”

Section: Introductionmentioning

confidence: 99%

“…For example, Chapman et al [34] analyzed data on >17,000 Americans and found that, compared to individuals with no history of childhood adversities, those with a history of childhood adversities were over two times more likely to report trouble falling or staying asleep. Koskenvuo et al [13] also examined the link between childhood adversities and troubled sleep among Finnish adults and found that adults who experienced multiple childhood adversities were over three times more likely to have troubled sleep than their counterparts who did not experience any adversities growing up. This association persisted after adjusting for work status, use of psychotropic drugs, health behaviors, recent life events, and child-parent relationships.…”

Section: Introductionmentioning

confidence: 99%

“…Thus, the objective of this paper was to further examine the association between earlychildhood adversities and troubled sleep in adulthood using a large, representative sample from Canada. In addition, of the few studies examining this relationship, one Finnish study controlled for additional factors associated with sleep, such as health behaviors, work status, and recent life events [13]. The current study aims to add to the literature by examining whether experiencing childhood adversities continue to be significantly associated with sleep problems later in adulthood after accounting for various sociodemographic, socioeconomic, health, and mental health factors within a North American sample.…”

Section: Introductionmentioning

confidence: 99%

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The enduring effects of early-childhood adversities and troubled sleep among Canadian adults: a population-based study

et al. 2015

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Association Between Childhood Behavioral Problems and Insomnia Symptoms in Adulthood

et al. 2019

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IMPORTANCE Life-course determinants of insomnia, particularly the long-term association of childhood behavioral problems with insomnia later in life, are unknown. As childhood behaviors are measurable and potentially modifiable, understanding their associations with insomnia symptoms may provide novel insights into early intervention strategies to reduce the burden. OBJECTIVE To investigate the association between behavioral problems at 5, 10, and 16 years of age and self-reported insomnia symptoms at 42 years of age. DESIGN, SETTING, AND PARTICIPANTS This cohort study used data from the United Kingdom 1970 Birth Cohort Study, an ongoing large-scale follow-up study. Participants were followed up from birth (1970) to age 42 years (2012). Missing data were imputed via multiple imputation. Statistical analysis was performed from February 1 to July 15, 2019. EXPOSURES Behavior measured at 5, 10, and 16 years of age using the Rutter Behavioral Scale (RBS). Children's behavior was classified as normal (Յ80th percentile), moderate behavioral problems (>80th to Յ95th percentile), and severe behavioral problems (>95th percentile) based on their RBS score. MAIN OUTCOMES AND MEASURES Self-reported difficulties initiating or maintaining sleep (DIMS) were collected using a self-administered questionnaire at 42 years of age. Log-binomial logistic regression, adjusted for several potential confounders, was used to estimate the association of childhood behavioral problems with insomnia symptoms in adulthood. Sensitivity analyses were conducted to check robustness of the findings. RESULTS Participants were followed up from a baseline age of 5 years (n = 8050; 3854 boys and 4196 girls), 10 years (n = 9090; 4365 boys and 4725 girls), or 16 years (n = 7653; 3575 boys and 4078 girls) until age 42 years. There was a 39% higher risk of DIMS

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Childhood adversities and quality of sleep in adulthood: A population-based study of 26,000 Finns

Cited by 117 publications

References 29 publications

Sleep and Behavior in Cross-Fostering Rats: Developmental and Sex Aspects

Sleep and Behavior in Cross-Fostering Rats: Developmental and Sex Aspects

The enduring effects of early-childhood adversities and troubled sleep among Canadian adults: a population-based study

Association Between Childhood Behavioral Problems and Insomnia Symptoms in Adulthood

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