Childhood adversity in an Australian population

Rosenman, Stephen; Rodgers, Bryan

doi:10.1007/s00127-004-0802-0

Cited by 140 publications

(104 citation statements)

References 32 publications

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“…ACEs were identified as a set of traumatic and stressful psychosocial conditions that are out of the child's control, that tend to co-occur (33), and that often persist over time (24,34). ACEs were defined as intrafamilial events or conditions causing chronic stress responses in the child's immediate environment.…”

Section: Methodsmentioning

confidence: 99%

Adverse childhood experiences and physiological wear-and-tear in midlife: Findings from the 1958 British birth cohort

Solís

Kelly-Irving

Fantin

et al. 2015

Proc. Natl. Acad. Sci. U.S.A.

167

105

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Allostatic load (AL) is a measure of overall physiological wear-andtear over the life course, which could partially be the consequence of early life exposures. AL could allow a better understanding of the potential biological pathways playing a role in the construction of the social gradient in adult health. To explore the biological embedding hypothesis, we examined whether adverse childhood experiences (ACEs) are associated with elevated AL in midlife. We used imputed data on 3,782 women and 3,753 men of the National Child Development Study in Britain followed up seven times. ACEs were measured using prospective data collected at ages 7, 11, and 16. AL was operationalized using data from the biomedical survey collected at age 44 on 14 parameters representing four biological systems. We examined the role of adult health behaviors, body mass index (BMI), and socioeconomic status as potential mediators using a path analysis. ACEs were associated with higher AL for both men and women after adjustment for early life factors and childhood pathologies. The path analysis showed that the association between ACEs and AL was largely explained by early adult factors at age 23 and 33. For men, the total mediated effect was 59% (for two or more ACEs) via health behaviors, education level, and wealth. For women, the mediated effect represented 76% (for two or more ACEs) via smoking, BMI, education level, and wealth. Our results indicate that early psychosocial stress has an indirect lasting impact on physiological wear-and-tear via health behaviors, BMI, and socioeconomic factors in adulthood.allostatic load | adverse childhood experiences | biological embedding | health behaviors | cohort study

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Section: Methodsmentioning

confidence: 99%

Adverse childhood experiences and physiological wear-and-tear in midlife: Findings from the 1958 British birth cohort

Solís

Kelly-Irving

Fantin

et al. 2015

Proc. Natl. Acad. Sci. U.S.A.

167

105

View full text Add to dashboard Cite

show abstract

“…a For retrospective reports at 45 years, information was obtained via direct computer data entry derived from the Personality and Total Health Through Life Project, 22 originating from the Parental Bonding Instrument, 23 British National Survey of Health and Development, 24 and the US National Comorbidity Survey. 25 Participants were instructed: "The following are statements about your childhood.…”

Section: -16 45 (S)mentioning

confidence: 99%

Child Maltreatment and Adult Living Standards at 50 Years

Pereira

Power

2017

Pediatrics

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“…There are many ways in which adversity can be conceptualised [24][25][26][27]. We have attempted to construct a theoretical framework prior to extracting any data, in order to create a measurement with a robust content validity.…”

Section: Adverse Childhood Experiences (Ace)mentioning

confidence: 99%

Reduced Visual Cortex Gray Matter Volume and Thickness in Young Adults Who Witnessed Domestic Violence during Childhood

2015

Holistic Perspectives on Trauma

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Background: To analyse whether Adverse Childhood Experiences (ACE) are associated with an increased risk of cancer. Methods: The National child development study (NCDS) is a prospective birth cohort study with data collected over 50 years. The NCDS included all live births during one week in 1958 (n = 18558) in Great Britain. Self-reported cancer incidence was based on 444 participants reporting having had cancer at some point and 5694 reporting never having cancer. ACE was measured using reports of: 1) child in care, 2) physical neglect, 3) child's or family's contact with the prison service, 4) parental separation due to divorce, death or other, 5) family experience of mental illness & 6) family experience of substance abuse. The resulting variable had three categories, no ACEs/ one ACE/ 2 + ACEs and was used to test for a relationship with cancer. Information on socioeconomic characteristics, pregnancy and birth were extracted as potential confounders. Information on adult health behaviours, socioeconomic environment, psychological state and age at first pregnancy were added to the models. Multivariate models were run using multiply-imputed data to account for missing data in the cohort. Results: The odds of having a cancer before 50 y among women increased twofold for those who had 2+ ACEs versus those with no ACEs, after adjusting for adult factors and early life confounders (OR: 2.1, 95% CI: 1.42-3.21, p < 0.001). Conclusion: These findings suggest that cancer risk may be influenced by exposure to stressful conditions and events early on in life. This is potentially important in furthering our understanding of cancer aetiology, and consequently in redirecting scientific research and developing appropriate prevention policies.

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Childhood adversity in an Australian population

Abstract: Some form of adversity is a common experience, although the severest abuses are less common in this population. Multiple adversities are common and only a minority experience single adversities. Physical abuse, sexual abuse and neglect rarely occur alone, but indicate a context of abuse.

Cited by 140 publications

References 32 publications

Adverse childhood experiences and physiological wear-and-tear in midlife: Findings from the 1958 British birth cohort

Adverse childhood experiences and physiological wear-and-tear in midlife: Findings from the 1958 British birth cohort

Child Maltreatment and Adult Living Standards at 50 Years

Reduced Visual Cortex Gray Matter Volume and Thickness in Young Adults Who Witnessed Domestic Violence during Childhood

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