Childhood adversity, prenatal depression, and maternal inflammation across pregnancy

Bublitz, Margaret H.; Freeburg, Taylor; Sharp, Meghan; Salameh, Myriam; Bourjeily, Ghada

doi:10.1177/1753495x211011910

Cited by 7 publications

(4 citation statements)

References 48 publications

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“…As a matter of fact, NLR is signi cantly higher in patients with AN and a history of CM compared to patients with AN without history of CM. This nding is in line to what has been recently demonstrated during pregnancy in women who have experienced childhood sexual abuse [35]. In this last study, NLR was signi cantly higher in pregnant women with a history of childhood sexual abuse independently from prenatal depression [35].…”

Section: Discussionsupporting

confidence: 92%

“…This nding is in line to what has been recently demonstrated during pregnancy in women who have experienced childhood sexual abuse [35]. In this last study, NLR was signi cantly higher in pregnant women with a history of childhood sexual abuse independently from prenatal depression [35]. The current medical literature points towards a role of epigenetics via DNA methylation on the HPA axis dysregulation and immune system activation after CM [36].…”

Section: Discussionsupporting

confidence: 89%

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Neutrophil-to-lymphocyte ratio (NLR) variations in relationship with childhood maltreatment in patients with anorexia nervosa: a retrospective cohort study

et al. 2022

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Purpose: Anorexia nervosa (AN) is a serious mental illness that is frequently accompanied with a history of childhood maltreatment (CM) which may constitute a speci c ecophenotype of the eating disorder necessitating special assessment and management. Chronic stress in icted by CM in patients with AN may manifest through increased low grade in ammation re ected by an increase in ratios from white blood cells count such as neutrophils to lymphocytes ratio (NLR) platelets to lymphocytes ratio (PLR) and monocytes to lymphocytes ratio (MLR).Methods: N=206 participants were evaluated in an eating disorders daycare unit in Montpellier, France between March 2013 and January 2020. CM was assessed using childhood trauma questionnaire (CTQ). AN clinical severity was assessed using eating disorder examination (EDE-Q). The MINI was used to assess other clinical characteristics.Results: NLR has been found to be higher in patients with AN and a history of CM (p=0.029) as well as in patients with AN and a history of emotional abuse (p=0.021) when compared to patients with AN and without a history of CM. In the multivariate analysis, emotional abuse (β=0.17; p=0.027) contributed signi cantly to NLR's variability.Conclusion: NLR is a low grade in ammation marker that is in uenced by multiple sociodemographic, clinical and biological factors in patients with AN. It is more directly affected by certain subtypes of CM, especially emotional abuse than by the presence or absence of a history of CM. Future studies may focus on mediators between CM and increased in ammation such as interoceptive awareness, emotional dysregulation, food addiction and stress-sensitization.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 89%

Neutrophil-to-lymphocyte ratio (NLR) variations in relationship with childhood maltreatment in patients with anorexia nervosa: a retrospective cohort study

et al. 2022

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“…Given the role of SEA in modulating inflammatory and pain processes as well as in regulating glucocorticoid secretion, lowered SEA levels in the hair of pregnant women with a CM history may implicate that CM contributes to an aberrant immune and HPA axis (re-)activity in late pregnancy through altered SEA regulation. Indeed, there is evidence that women with CM history exhibit higher inflammatory activity during pregnancy (Boeck et al, 2016 ; Bublitz, De La Monte, Martin, Larson, & Bourjeily, 2017 , 2022 ; Kleih et al, 2022 ). NAEs are known to inhibit inflammation by binding to peroxisome proliferator-activated-receptors (PPAR) (O'Sullivan & Kendall, 2010 ), and therefore a reduced SEA signaling may contribute to increased inflammation in pregnant women with a history of CM.…”

Section: Discussionmentioning

confidence: 99%

Longitudinal course of endocannabinoids andN-acylethanolamines in hair of mothers and their children in the first year postpartum: investigating the relevance of maternal childhood maltreatment experiences

et al. 2023

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Background Childhood maltreatment (CM) exerts long-lasting psychological and biological alterations in affected individuals and might also affect the endocannabinoid (eCB) system which modulates inflammation and the endocrine stress response. Here, we investigated the eCB system of women with and without CM and their infants using hair samples representing eCB levels accumulated during the last trimester of pregnancy and 10–12 months postpartum. Methods CM exposure was assessed with the Childhood Trauma Questionnaire. At both timepoints, 3 cm hair strands were collected from mothers and children (N = 170 resp. 150) to measure anandamide (AEA), 2/1-arachidonoylglycerol (2-AG/1-AG), stearoylethanolamide (SEA), oleoylethanolamide (OEA), and palmitoylethanolamide (PEA). Results Maternal hair levels of 2-AG/1-AG increased and SEA levels decreased from late pregnancy to one year postpartum. Maternal CM was associated with lower SEA levels in late pregnancy, but not one year later. In the children's hair, levels of 2-AG/1-AG increased while levels of SEA, OEA, and PEA decreased from late pregnancy to one year later. Maternal CM was not consistently associated with the eCB levels measured in children's hair. Conclusions We provide first evidence for longitudinal change in the eCB system of mothers and infants from pregnancy to one year later. While maternal CM influenced the maternal eCB system, we found no consistent intergenerational effects on early regulation of the eCB system in children. Longitudinal research on the importance of the eCB system for the course and immunoregulation of pregnancy as well as for the children's development.

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“…no abuse). Finally, Bublitz et al [35] showed that a CSA history was linked to a greater change in the Neutrophil-lymphocyte ratio (NLR, a measure of systematic inflammation) over pregnancy.…”

Section: Biomedical Risksmentioning

confidence: 99%

Childhood abuse and perinatal outcomes for mother and child: A systematic review of the literature

Brunton

2024

PLoS ONE

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Childhood abuse can have long-term adverse outcomes in adulthood. These outcomes may pose a particular threat to the health and well-being of perinatal women; however, to date, this body of knowledge has not been systematically collated and synthesized. This systematic review examined the child abuse literature and a broad range of perinatal outcomes using a comprehensive search strategy. The aim of this review was to provide a clearer understanding of the distinct effect of different abuse types and areas where there may be gaps in our knowledge. Following PRISMA guidelines, EBSCO, PsychInfo, Scopus, Medline, CINAHL, PubMed, and Google Scholar databases and gray literature including preprints, dissertations and theses were searched for literature where childhood abuse was associated with any adverse perinatal outcome between 1969 and 2022. Exclusion criteria included adolescent samples, abuse examined as a composite variable, editorials, letters to the editor, qualitative studies, reviews, meta-analyses, or book chapters. Using an assessment tool, two reviewers extracted and assessed the methodological quality and risk of bias of each study. From an initial 12,384 articles, 95 studies were selected, and the outcomes were categorized as pregnancy, childbirth, postnatal for the mother, and perinatal for mother and child. The prevalence of childhood abuse ranged from 5–25% with wide variability (physical 2–78%, sexual 2–47%, and emotional/psychological 2–69%). Despite some consistent findings relating to psychological outcomes (i.e., depression and PTSD), most evidence was inconclusive, effect sizes were small, or the findings based on a limited number of studies. Inconsistencies in findings stem from small sample sizes and differing methodologies, and their diversity meant studies were not suitable for a meta-analysis. Research implication include the need for more rigorous methodology and research in countries where the prevalence of abuse may be high. Policy implications include the need for trauma-informed care with the Multi-level Determinants of Perinatal Wellbeing for Child Abuse Survivors model a useful framework. This review highlights the possible impacts of childhood abuse on perinatal women and their offspring and areas of further investigation. This review was registered with PROSPERO in 2021 and funded by an internal grant from Charles Sturt University.

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Childhood adversity, prenatal depression, and maternal inflammation across pregnancy

Cited by 7 publications

References 48 publications

Neutrophil-to-lymphocyte ratio (NLR) variations in relationship with childhood maltreatment in patients with anorexia nervosa: a retrospective cohort study

Neutrophil-to-lymphocyte ratio (NLR) variations in relationship with childhood maltreatment in patients with anorexia nervosa: a retrospective cohort study

Longitudinal course of endocannabinoids andN-acylethanolamines in hair of mothers and their children in the first year postpartum: investigating the relevance of maternal childhood maltreatment experiences

Childhood abuse and perinatal outcomes for mother and child: A systematic review of the literature

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