Childhood and Adolescent Depression: A Review of the Past 10 Years. Part I

Birmaher, Boris; Ryan, Neal D.; Williamson, Douglas E.; Brent, David A.; Kaufman, Joan; Dahl, Ronald E.; Perel, James M.; Nelson, Beverly

doi:10.1097/00004583-199611000-00011

Cited by 1,669 publications

(1,080 citation statements)

References 177 publications

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“…For example, a meta analysis (Angold et al 1999) of depression comorbidity with these other symptoms and disorders among community samples revealed that depression was associated with anxiety (median odds ratio=8.2), conduct/oppositional problems (median odds ratio=6.6), and ADHD (median odds ratio=5.5). In addition, comorbid depression is associated with more severe symptoms and correlates as well as worse clinical course and potential treatment outcomes (Birmaher et al 1996;Lewinsohn et al 1995). Finally, the developmental epidemiology literature has also identified developmental patterns of sequential comorbidity.…”

Section: Introductionmentioning

confidence: 99%

Cognitive Vulnerability–Stress Model of Depression During Adolescence: Investigating Depressive Symptom Specificity in a Multi-Wave Prospective Study

Hankin

2008

J Abnorm Child Psychol

132

110

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Depression commonly co-occurs with anxiety and externalizing problems. Etiological factors from a central cognitive theory of depression, the Hopelessness Theory (Abramson et al. Psychological Review, 96, 358-372, 1989), were examined to evaluate whether a negative inferential style about cause, consequence, and self interacted with stressors over time to predict prospective elevations in depressive symptoms specifically compared with typically co-occurring symptoms. Negative inferential style was assessed at baseline in a sample of early and middle adolescents (N=350, sixth to tenth graders). Measures of general depressive, anhedonic depressive, anxious arousal, general internalizing, and externalizing symptoms and occurrence of stressors were assessed at four time points over a 5-month period. Results using hierarchical linear modeling show that a negative inferential style interacted with negative events to predict prospective symptoms of general and anhedonic depression specifically but not anxious arousal, general internalizing or externalizing symptoms. Negative events predicted prospective elevations of symptoms of anxious arousal, internalizing, and externalizing problems.

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Section: Introductionmentioning

confidence: 99%

Cognitive Vulnerability–Stress Model of Depression During Adolescence: Investigating Depressive Symptom Specificity in a Multi-Wave Prospective Study

Hankin

2008

J Abnorm Child Psychol

132

110

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“…1 The prevalence of the juvenile-onset subtype of depressive disorder increases dramatically across the years of childhood and adolescence, with an estimated lifetime prevalence close to 20% by late adolescence. 2 Juvenile-onset mood disorders are associated with serious morbidity, including recurrence, impaired interpersonal functioning, and increased risks of bipolar disorder and suicide. 2,3 The influence of hereditary factors on susceptibility to major depression has been documented based on twin and adoption studies.…”

mentioning

confidence: 99%

“…2 Juvenile-onset mood disorders are associated with serious morbidity, including recurrence, impaired interpersonal functioning, and increased risks of bipolar disorder and suicide. 2,3 The influence of hereditary factors on susceptibility to major depression has been documented based on twin and adoption studies. 4 Twin studies in youth have identified significant heritability for depressive symptoms.…”

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confidence: 99%

Brain-derived neurotrophic factor variants are associated with childhood-onset mood disorder: confirmation in a Hungarian sample

et al. 2005

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Brain-derived neurotrophic factor (BDNF) is a nerve growth factor that has been implicated in the neurobiology of depression. Our group has previously reported an association between a BDNF variant and childhood-onset mood disorder (COMD) in an adult sample from Pittsburgh. We hypothesize that variants at the BDNF locus are associated with COMD. Six BDNF polymorphisms were genotyped in 258 trios having juvenile probands with childhood-onset DSM-IV major depressive or dysthymic disorder. Keywords: neurotrophic factors; mood disorder; childhood-onset; genetic association; haplotype Mood disorders rank fourth among the most significant global public health problems. 1 The prevalence of the juvenile-onset subtype of depressive disorder increases dramatically across the years of childhood and adolescence, with an estimated lifetime prevalence close to 20% by late adolescence. 2 Juvenile-onset mood disorders are associated with serious morbidity, including recurrence, impaired interpersonal functioning, and increased risks of bipolar disorder and suicide. 2,3 The influence of hereditary factors on susceptibility to major depression has been documented based on twin and adoption studies. 4 Twin studies in youth have identified significant heritability for depressive symptoms. 5,6 It has also been proposed that genetic aspects of liability to mood disorder may be more readily identified in families of childhood-and adolescentonset probands. 7 Accordingly, first-degree relatives of childhood-onset mood disorder probands have higher rates of affective disorder than do first-degree relatives of adult-onset mood disorder probands. 8 Evidence from both preclinical and clinical studies implicates brain-derived neurotrophic factor (BDNF) in mood disorders. Altered BDNF expression in stress-related depression via cellular signalling has been described in animal models. Repeated antidepressant administration, including electroconvulsive seizures, is associated with increased hippocampal BDNF expression, neuronal plasticity and neurogenesis. 9-11 Human neuroimaging 12,13 post mortem 14 and clinical [15][16][17] investigations indirectly support the hypothesis that neurotrophic factors play a key role in depression. As well, human linkage studies in

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“…Different studies have revealed that prevalence of depression among adolescents is higher in females as compared to males. The differences in diagnosis have been reported between 13-15 years of age among both genders (1,2).…”

Section: Introductionmentioning

confidence: 92%

Increasing Factors of Depression Among School Children Aged 10-15 Years

2017

GMJ

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Objective: Major depressive disorder is an escalating problem in both developed and under developed countries. Similar to the adolescents, depressive symptoms have been diagnosed at an extensive level among school going children. The study is based around investigating the increasing factors of depression among school going children of Jordan. Methods: A sample of 1650 school going students from Amman has been considered, which was assessed on behalf of two instruments. The age group of 10-15 years was identified for recruiting students from five government and five private schools. The collected data was analyzed through SPSS version 20. Results: Findings of the study reflected that depression in childhood is strongly associated with ecological factors and psychiatric co-morbidities. Furthermore, the results revealed that age, gender, living arrangements, and domestic violence are also associated with childhood depression. The results further identified that the prevalence rate of depression is higher in girls as compared to the boys. Conclusion: Depression can become more severe, if it is not managed at the early stage. Similarly, depression in childhood is likely to continue in adulthood if it is not properly treated at initial stages. Moreover, the rate of depression vary across the globe due to the different social and economic factors of each country.

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Childhood and Adolescent Depression: A Review of the Past 10 Years. Part I

Cited by 1,669 publications

References 177 publications

Cognitive Vulnerability–Stress Model of Depression During Adolescence: Investigating Depressive Symptom Specificity in a Multi-Wave Prospective Study

Cognitive Vulnerability–Stress Model of Depression During Adolescence: Investigating Depressive Symptom Specificity in a Multi-Wave Prospective Study

Brain-derived neurotrophic factor variants are associated with childhood-onset mood disorder: confirmation in a Hungarian sample

Increasing Factors of Depression Among School Children Aged 10-15 Years

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