Childhood and adolescent mental health of NICU graduates: an observational study

Chiorean, Andreea; Savoy, Calan; Beattie, Karen A.; Helou, Salhab el; Silmi, Maysoon; Lieshout, Ryan J. Van

doi:10.1136/archdischild-2019-318284

Cited by 17 publications

(12 citation statements)

References 35 publications

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“…Neonatal ICU (NICU) and pediatric ICU (PICU) survivors have been found to suffer from common psychiatric disorders, including depression, anxiety and post-ICU syndromes [5,6,13,14], and from new or increasing impairments in various cognitive functions [6][7][8]. Major identified risk factors which account for these impairments are both the critical illness itself in addition to elements related to hospitalization in and of itself.…”

Section: Introductionmentioning

confidence: 99%

A systematic review of the impact of intensive care admissions on post discharge cognition in children

Royer

Busari

2021

Eur J Pediatr

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Understanding how hospitalization affects cognitive development is crucial to safeguard children’s cognition; however, there is little research evaluating the associations between NICU or PICU hospitalization and survivors’ cognition. The objective of this study is to identify and characterize the associations between a neonatal or pediatric ICU hospitalization and the short- and long-term cognition of survivors. The databases Cochrane Library, Medline, EBSCO, Embase, and Google Scholar and the journals JAMA Pediatrics, Journal of Pediatrics, Pediatrics, Archives of Disease in Childhood, Academic Pediatrics, Pediatric Critical Care Medicine and Child Development were searched until April 2021. Retrieved article references were analyzed. Included articles investigated cognition as an outcome of ICU hospitalization in non-preterm neonatal or pediatric patients. Case studies and studies analyzing diagnosis or treatment interventions were excluded. Four prospective cohort or case-control studies and two retrospective cohort studies were included, totaling 2172 neonatal and 42368 pediatric patients. Quality assessment using the BMJ Criteria and Cochrane Collaboration’s Risk-of-Bias tool displayed good results. Significant negative associations were found between neonatal cognition and length-of-ICU-stay at 9- (p<0.001) and 24 months (p<0.01), and between pediatric cognition and length-of-ICU-stay at discharge (p<0.001). Additional weeks on the neonatal ICU increased odds of impairment at 9- (OR 1.08, 95%CI 1.034–1.112) and 24 months (OR 1.11, 95%CI 1.065–1.165).Conclusion: There is a significant negative correlation between NICU and PICU hospitalization and the short- and long-term cognitive status. Future research must identify patient- and hospital-related risk factors and develop management strategies. What is Known:• Cognitive development relies on the presence of stimulating factors and absence of risk factors, and is hypothesized to be directly and indirectly affected by hospitalization in the short and long term.• No research examines the relation between survivor cognition post-discharge of a general pediatric hospitalization, and scarcely more of a neonatal or pediatric intensive care hospitalization. What is New:• NICU and PICU hospitalization is independent risk factors for survivor impaired cognition in the short and in the long term with a dose-response effect. High risk patients for cognitive impairment should be identified and appropriately followed-up.• Patients with an ICU hospitalization of over 2.5 days and two or more of the following factors should be considered high risk: increased mortality risk, invasive interventions, neurological or oncological diagnosis, postnatal complications or decreased maternal mental health status.

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Section: Introductionmentioning

confidence: 99%

A systematic review of the impact of intensive care admissions on post discharge cognition in children

Royer

Busari

2021

Eur J Pediatr

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“…In addition, the study showed that preterm children with BPD are at particular risk for poor academic outcome, which, among others, may be due to the fact that the BPD frequency is increasing among neonates with extremely low BW and GA [30]. Preterm infants are more likely to show behavioural and psychologi-cal problems compared to full-term babies [31]. These children more often develop attention deficit hyperactivity disorder (ADHD), autism spectrum disorder, emotional and conduct problems (including anxiety and depression) or difficulties in contacts with peers.…”

Section: Neurodevelopmental Outcomementioning

confidence: 95%

Development of a preterm baby – an overview of current knowledge

Mlodawska¹,

Pazera²,

Młodawski³

2021

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The psychomotor development of children is very important outcome concerning the proper growth and development of a child. We try to eliminate the risk factors that impair its course during intrauterine life, during childbirth, as well as during the first months/years of life, to provide children with optimal conditions for healthy development. Newborns born prematurely are at risk of impaired psychomotor development, including cognitive, neurological, and/or sensory outcomes. The following review presents risk factors that weaken the development of preterm infants, the areas of development in which this weakness may be visible, and methods of evaluation of this development. StreszczenieRozwój psychoruchowy dzieci to bardzo ważny element oceny mówiący o prawidłowym dorastaniu i rozwoju dziecka. Staramy się zniwelować czynniki ryzyka zaburzające jego przebieg w trakcie życia wewnątrzmacicznego, w czasie porodu, jak również w pierwszych miesiącach lub latach życia, aby zapewnić dzieciom optymalne warunki do prawidłowego rozwoju. Noworodki urodzone przedwcześnie z powodu utraty optymalnych warunków rozwoju, jakie zapewnia organizm matki, znajdują się w grupie ryzyka osłabionego rozwoju psychoruchowego, obejmującego wyniki poznawcze, neurologiczne czy sensoryczne. Poniższe opracowanie przedstawia czynniki osłabiające rozwój wcześniaków, płaszczyzny rozwoju, w których to osłabienie może być widoczne, oraz metody oceny rozwoju.

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“…No register studies examined specific anxiety disorders separately. One small cohort study found that treatment in a neonatal intensive care unit (NICU) was associated with specific phobias ( 19 ) and two identified it to associate with separation anxiety disorders ( 19 , 20 ).…”

Section: Introductionmentioning

confidence: 99%

Associations Between Delivery Modes, Birth Outcomes and Offspring Anxiety Disorders in a Population-Based Birth Cohort of Children and Adolescents

et al. 2022

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ObjectiveMode of delivery and well-being markers for newborn infants have been associated with later psychiatric problems in children and adolescents. However, only few studies have examined the association between birth outcomes and anxiety disorders and the results have been contradictory.MethodsThis study was a Finnish population-based register study, which comprised 22,181 children and adolescents with anxiety disorders and 74,726 controls. Three national registers were used to collect the data on exposures, confounders and outcomes. Mode of delivery, the 1-min Apgar score, umbilical artery pH and neonatal monitoring were studied as exposure variables for anxiety disorders and for specific anxiety disorders. Conditional logistic regression was used to examine these associations.ResultsUnplanned and planned cesarean sections increased the odds for anxiety disorders in children and adolescents (adjusted OR 1.08, 95% CI 1.02–1.15 and aOR 1.12, 95% CI 1.05–1.19, respectively). After an additional adjustment for maternal diagnoses, unplanned cesarean sections remained statistically significant (aOR 1.11, 95% CI 1.04–1.18). For specific anxiety disorders, planned cesarean sections and the need for neonatal monitoring increased the odds for specific phobia (aOR 1.21, 95% CI 1.01–1.44 and aOR 1.28, 95% CI 1.07–1.52, respectively).ConclusionsBirth by cesarean section increased the odds for later anxiety disorders in children and adolescents and unplanned cesarean sections showed an independent association. Further studies are needed to examine the mechanisms behind these associations.

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Childhood and adolescent mental health of NICU graduates: an observational study

Cited by 17 publications

References 35 publications

A systematic review of the impact of intensive care admissions on post discharge cognition in children

A systematic review of the impact of intensive care admissions on post discharge cognition in children

Development of a preterm baby – an overview of current knowledge

Associations Between Delivery Modes, Birth Outcomes and Offspring Anxiety Disorders in a Population-Based Birth Cohort of Children and Adolescents

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