Childhood and Adulthood Severe Stressful Experiences and Biomarkers Related to Glucose Metabolism: A Possible Association?

Tosato, Sarah; Bonetto, Chiara; Lopizzo, Nicola; Cattane, Nadia; Barcella, Mara; Turco, G.; Ruggeri, Mirella; Provasi, Stefania; Tomassi, Simona; Dazzan, Paola; Cattaneo, Annamaria

doi:10.3389/fpsyt.2021.629137

Cited by 6 publications

(3 citation statements)

References 30 publications

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“…The higher weight in babies born to HCT mothers observed in our study might be associated with impaired glucose metabolism 41,42 which in the future might result in an increased risk of glucose intolerance and metabolic syndrome. Such effects usually co-occur with overweight and obesity 2,43 and have been previously reported in www.nature.com/scientificreports/ adult descendants of parents with higher trauma 44 .…”

Section: Discussionmentioning

confidence: 62%

Maternal childhood trauma is associated with offspring body size during the first year of life

Apanasewicz

Danel

Piosek

et al. 2022

Sci Rep

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Maternal childhood trauma (MCT) is an important factor affecting offspring size at birth. Whether the effect of MCT persists during the subsequent development remains unclear. We present the results of a semi-longitudinal investigation examining the physical growth of infants born to mothers with high (HCT) and low (LCT) childhood trauma during the first year of life. One hundred healthy mother-infant dyads were included based on following criteria: exclusive breastfeeding, birth on term with appropriate weight for gestational age. MCT was assessed using the Early Life Stress Questionnaire. The weight, length, and head circumference of the infant were taken at birth, 5 and 12 months postpartum. Separate MANCOVA models were run for infant size at each age. We found an association between MCT and infant size at 5 and 12 months. The children of mothers with HCT had higher weight and greater head circumference than the children of mothers with LCT. These results suggest that MCT might contribute to developmental programming of offspring growth during the first year of life. From an evolutionary perspective, the larger size of HCT mother's offspring might represent an adaptation to potentially harsh environmental conditions. This effect might be mediated by epigenetic changes to DNA and altered breast milk composition.

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Section: Discussionmentioning

confidence: 62%

Maternal childhood trauma is associated with offspring body size during the first year of life

Apanasewicz

Danel

Piosek

et al. 2022

Sci Rep

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“…Strong and sustained activation of the sympathetic nervous system (SNS) and hypothalamic-pituitary-adrenal (HPA) axis during stress leads to hyperglycemia, hypercortisolism, inflammation, and insulin resistance [ 126 , 127 ]. Furthermore, Kim points out that the main deleterious effects of stress are caused primarily by alterations in neural circuits that affect the functions of all body systems [ 128 ].…”

Section: Stress Ptsd and Obesity-related Morbiditiesmentioning

confidence: 99%

360-Degree Perspectives on Obesity

Cuciureanu,

Caratașu,

Gabrielian

et al. 2023

Medicina

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Alarming statistics show that the number of people affected by excessive weight has surpassed 2 billion, representing approximately 30% of the world’s population. The aim of this review is to provide a comprehensive overview of one of the most serious public health problems, considering that obesity requires an integrative approach that takes into account its complex etiology, including genetic, environmental, and lifestyle factors. Only an understanding of the connections between the many contributors to obesity and the synergy between treatment interventions can ensure satisfactory outcomes in reducing obesity. Mechanisms such as oxidative stress, chronic inflammation, and dysbiosis play a crucial role in the pathogenesis of obesity and its associated complications. Compounding factors such as the deleterious effects of stress, the novel challenge posed by the obesogenic digital (food) environment, and the stigma associated with obesity should not be overlooked. Preclinical research in animal models has been instrumental in elucidating these mechanisms, and translation into clinical practice has provided promising therapeutic options, including epigenetic approaches, pharmacotherapy, and bariatric surgery. However, more studies are necessary to discover new compounds that target key metabolic pathways, innovative ways to deliver the drugs, the optimal combinations of lifestyle interventions with allopathic treatments, and, last but not least, emerging biological markers for effective monitoring. With each passing day, the obesity crisis tightens its grip, threatening not only individual lives but also burdening healthcare systems and societies at large. It is high time we took action as we confront the urgent imperative to address this escalating global health challenge head-on.

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“…Biological, behavioral, and psychological mechanisms likely link stress, including CT, to metabolic disorders (Kivimäki, Bartolomucci, & Kawachi, 2023). Suspected biological mechanisms involve increased glycemia and insulin resistance (Nasca et al, 2019;Tosato et al, 2021), immune dysfunction and increased inflammation (Crick et al, 2022), accelerated biological aging (Rentscher et al, 2019), and increased adiposity and changes in body composition (Danese & Tan, 2014;Hemmingsson, Johansson, & Reynisdottir, 2014). Additional recent evidence points toward the role of epigenetics through which the effects of CT would become biologically embedded to affect adult health (Womersley et al, 2021).…”

Section: )mentioning

confidence: 99%

Metabolic syndrome after childhood trauma: a 9-year longitudinal analysis

Souama,

Milaneschi,

Lamers

et al. 2023

Psychol. Med.

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Background Childhood trauma (CT) has been cross-sectionally associated with metabolic syndrome (MetS), a group of biological risk factors for cardiometabolic disease. Longitudinal studies, while rare, would clarify the development of cardiometabolic dysregulations over time. Therefore, we longitudinally investigated the association of CT with the 9-year course of MetS components. Methods Participants (N = 2958) from the Netherlands Study of Depression and Anxiety were assessed four times across 9 years. The CT interview retrospectively assessed childhood emotional neglect and physical, emotional, and sexual abuse. Metabolic outcomes encompassed continuous MetS components (waist circumference, triglycerides, high-density lipoprotein [HDL] cholesterol, blood pressure [BP], and glucose) and count of clinically elevated MetS components. Mixed-effects models estimated sociodemographic- and lifestyle-adjusted longitudinal associations of CT with metabolic outcomes over time. Time interactions evaluated change in these associations. Results CT was reported by 49% of participants. CT was consistently associated with increased waist (b = 0.32, s.e. = 0.10, p = 0.001), glucose (b = 0.02, s.e. = 0.01, p < 0.001), and count of MetS components (b = 0.04, s.e. = 0.01, p < 0.001); and decreased HDL cholesterol (b = −0.01, s.e.<0.01, p = .020) and systolic BP (b = −0.33, s.e. = 0.13, p = 0.010). These associations were mainly driven by severe CT and unaffected by lifestyle. Only systolic BP showed a CT-by-time interaction, where CT was associated with lower systolic BP initially and with higher systolic BP at the last follow-up. Conclusions Over time, adults with CT have overall persistent poorer metabolic outcomes than their non-maltreated peers. Individuals with CT have an increased risk for cardiometabolic disease and may benefit from monitoring and early interventions targeting metabolism.

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Childhood and Adulthood Severe Stressful Experiences and Biomarkers Related to Glucose Metabolism: A Possible Association?

Cited by 6 publications

References 30 publications

Maternal childhood trauma is associated with offspring body size during the first year of life

Maternal childhood trauma is associated with offspring body size during the first year of life

360-Degree Perspectives on Obesity

Metabolic syndrome after childhood trauma: a 9-year longitudinal analysis

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