Childhood asthma and obesity—what is the true link?

Permaul, Perdita; Kanchongkittiphon, Watcharoot; Phipatanakul, Wanda

doi:10.1016/j.anai.2014.07.001

Cited by 40 publications

(28 citation statements)

References 27 publications

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“…Overweight/obese children also had lower fraction of exhaled nitric oxide values, which is not surprising given the predominantly neutrophilic inflammation associated with obese asthmatic patients in numerous other studies. 4 Despite the fact that the 2 groups were similar in regard to levels of controller therapy and health care use, overweight/obese children in this study reported 3 times more rescue bronchodilator use per week. In addition, Lang et al 9 found that overweight/obese children were more likely to identify shortness of breath (odds ratio, 11.8; 95% CI, 1.41-98.7) and less likely to identify cough (odds ratio, 0.26; 95% CI, 0.08-0.82) as their primary symptom associated with loss of control compared with lean children.…”

mentioning

confidence: 70%

“…We must exercise caution in extrapolating data from adult populations because their characteristics might differ significantly from those of children. 4 The article by Lang et al 9 in this issue of the Journal offers a new perspective that identifies differences in symptoms exhibited by overweight/obese children (> _85% body mass index) with asthma compared with lean matched control subjects (20% to 65% body mass index). The authors included children aged 10 to 17 years with a physician's diagnosis of persistent asthma who also had confirmatory objective lung function, methacholine test results, or both.…”

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confidence: 97%

“…Several biologically plausible interactions have been proposed, including mechanical forces involved in ventilation; chronic systemic inflammation; hormonal influences, including leptin and adiponectin; and additional comorbidities, such as gastroesophageal reflux (GER) and hypertension. 3,4 Complicated genetic factors are involved in the development of both obesity and asthma. Interestingly, they even share some of the same candidate pleiotropic genes thought to be involved in the development of both diseases, including genes encoding the b 2 -adrenergic receptor, vitamin D receptor, leptin, protein kinase Ca, and TNF-a.…”

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confidence: 99%

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Obesity and asthma: The chicken or the egg?

Stukus

2015

Journal of Allergy and Clinical Immunology

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confidence: 99%

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Obesity and asthma: The chicken or the egg?

Stukus

2015

Journal of Allergy and Clinical Immunology

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“…Estimates were minimally attenuated, for example the OR for BMI gain from term to 4 months fell from 1.3 to 1.2. The aetiology of the link between obesity and asthma in children remains unclear, but proposed common underlying mechanisms include genetic or epigenetic factors, environmental factors such as diet and physical activity, mechanical effects, and inflammatory and non-inflammatory pathways 27. Emerging data suggest that early-life exposure to antibiotics may be a common antecedent in the development of asthma28 and obesity 29.…”

Section: Discussionmentioning

confidence: 99%

Preterm infant growth and asthma at age 8 years

Belfort

Cohen

Rhein

et al. 2015

Arch Dis Child Fetal Neonatal Ed

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“…of asthma and obesity [18]. single studies demonstrate the protective effect of a diet rich in vegetables, fruit and fish during pregnancy on the maturation of the immune and respiratory systems [19].…”

Section: Studied Group Smentioning

confidence: 99%

Prevalence of atopy and asthma in overweight children and adolescents – a cross-sectional study

Wytrychowski

Gałka²,

Hans-Wytrychowska

2017

fmpcr

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Background.A steady growth in the prevalence of asthma and overweight in children has been observed over the last three decades. there is a lot of evidence that obesity in children is a risk factor in the development of asthma. Objectives. We examined the relationship between obesity and development of atopy and asthma in children aged 6-18. Material and methods. A cross-sectional study was performed based on the medical records of 175 children and adolescents treated at the allergology outpatient clinic with diagnosed atopic diseases. From the same age population of patients of the general medicine clinic, the medical records of 207 children and adolescents were randomly chosen as a control group. in study group, atopy was confirmed with the use of skin prick tests or the measurement of specific ige antibodies. the weight, height and BMi were determined for all the studied children. Both groups were divided into subgroups of younger children (≤ 12 years) and adolescents (> 12 years). Results. in both groups, overweight children (BMi > 25; > 85 th percentile) were identified. the groups were uniform as regards gender, age and BMi. the percentage of overweight children was greater in the group with atopy than in the control group (14.3% vs 5.3%; p = 0.043). in the groups ≤ 12 and > 12, the percentage of overweight and obese children was higher in the group with atopy than in the control group, but the difference was statistically insignificant (p = 0.142 and p = 0.061, respectively). in the group with atopy, the number of overweight children suffering from asthma was significantly smaller in the group of younger children than in the group of older children (7.4% vs 20.2%; p = 0.028). in the group with atopy, there were 148 children with correct body weight, out of which 2 children (1.3%) were diagnosed with asthma. 23 out of 25 overweight children (92%) were diagnosed with asthma (p < 0.001). Conclusions. in the studied population of children and adolescents with atopic diseases, the prevalence of overweight was greater compared with their healthy peers. Bronchial asthma is an atopic disease connected with a high prevalence of overweight and obesity in the studied subjects. Key words: obesity, bronchial asthma, children and adolescents. Wytrychowski k, gałka A, Hans-Wytrychowska A. Prevalence of atopy and asthma in overweight children and adolescents -a cross--sectional study.

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Childhood asthma and obesity—what is the true link?

Cited by 40 publications

References 27 publications

Obesity and asthma: The chicken or the egg?

Obesity and asthma: The chicken or the egg?

Preterm infant growth and asthma at age 8 years

Prevalence of atopy and asthma in overweight children and adolescents – a cross-sectional study

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