Childhood Asthma Control Test and airway inflammation evaluation in asthmatic children

Piacentini, Giorgio; Peroni, Diego; Bodini, Alessandro; Bonafiglia, Elena; Rigotti, E; Baraldi, Eugenio; Ah, Liu; Boner, Attilio

doi:10.1111/j.1398-9995.2009.02068.x

Cited by 53 publications

(48 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…[18][19][20] For children, the cACT has more validation data than other tools that target children with asthma. [37][38][39] Also, the populations used in the validation studies vary between tools. For instance, in the United States, studies have included mostly white patients.…”

Section: Discussionmentioning

confidence: 99%

“…[37][38][39][40] In the developmental study, Liu et al 36 reported that the cACT overall score discriminated between patients who differ in the specialists' rating of asthma control. Similarly, Chen et al 37 reported that mean cACT scores were significantly lower among patients with poor asthma control as compared with those who were well controlled according to specialists' rating.…”

Section: Validitymentioning

confidence: 99%

“…36,44,45 On the contrary, the correlations between the cACT scores and the physiologic tests of asthma, lung function measures and F ENO , were not substantial. 36,37,39,46 …”

Section: Validitymentioning

confidence: 99%

See 2 more Smart Citations

Asthma Control Assessment Tools

Alzahrani

Becker

2015

Respir Care

View full text Add to dashboard Cite

, and they emphasize periodic assessment of asthma control once treatment is established. Accurate assessment of asthma control is difficult due to the complexity of asthma control and due to the limitations in the traditional methods of assessment, such as lung function tests, physician assessment, and patients' self-assessment. Relying solely on the role of lung function tests is insufficient to reflect the status of asthma control, since patients with asthma may have normal spirometry between exacerbations. Clinicians often overestimate the level of asthma control. Similarly, it is not uncommon for patients to overestimate how well their asthma is controlled, and, therefore, they under-report asthma symptoms and fail to recognize the impact that asthma has on their daily life. As a result, several tools have been developed to quantify the level of asthma control, identify patients at risk, and evaluate the effect of asthma management. This review examines the commonly 106RESPIRATORY CARE • JANUARY 2016 VOL 61 NO 1 used asthma control assessment tools in terms of content, psychometric properties, methods of administration, limitations, and ability to reflect the overall status of asthma control, which can aid clinicians in selecting the most appropriate tool for their needs.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Validitymentioning

confidence: 99%

See 1 more Smart Citation

Asthma Control Assessment Tools

Alzahrani

Becker

2015

Respir Care

View full text Add to dashboard Cite

show abstract

“…Moreover, there is no general consensus about correlation between F ENO and respiratory function in children. 2,[21][22][23][24][25][26][27][28][29][30][31][32][33][34] The main limitation of our study is the retrospective design. We gathered data from the subjects' medical documentation, which could partly have influenced the accuracy of our results.…”

Section: Discussionmentioning

confidence: 99%

The Interpretation of Exhaled Nitric Oxide Values in Children With Asthma Depends on the Degree of Bronchoconstriction and the Levels of Asthma Severity

et al. 2013

View full text Add to dashboard Cite

BACKGROUND:The clinical implications of fractional exhaled nitric oxide (F ENO ) measurements in childhood asthma are unclear. We aimed to evaluate the relationship between the level of exhaled nitric oxide and pre-bronchodilator FEV 1 and the change in FEV 1 after bronchodilator in children with asthma. METHODS: This was a retrospective, cross-sectional study. We evaluated data from medical documentation of children with asthma with special attention to F ENO results, asthma severity, FEV 1 (% predicted), and bronchial reversibility test. RESULTS: Four hundred and five subjects (age 6 -18 y) completed the study. Median levels of F ENO increased linearly with subjects' age (P ‫؍‬ .03). We found a nonlinear trend of pre-bronchodilator FEV 1 across 4 quartiles of F ENO in episodic and mild asthma; we observed lower pre-bronchodilator FEV 1 in children with higher F ENO , but only up to the F ENO value of 35.4 ppb; in children with F ENO value > 35.4 ppb, prebronchodilator FEV 1 was increased. We found a linear increasing trend of change from baseline (after 400 g of salbutamol) in FEV 1 across F ENO categories in children with moderate asthma. CONCLUSIONS: Our results suggest a need to measure F ENO before as well as after spirometry. Consequently, in children with asthma with bronchial obstruction, we suggest assessing F ENO after short-acting ␤ 2 agonists as well. (ClinicalTrials.gov registration NCT00815984.)

show abstract

“…14 -16 The ACQ and ACT have been validated for use as self-administered instruments in person, at home, by telephone, and by Internet tracking. 6,17 Poor asthma control, as measured by the commonly used composite scores, is associated with reduced lung function and elevated exhaled nitric oxide fraction 5,18 (discussed later in the article). Studies have shown that changes in these composite scores reflect changes in the overall clinical assessment of asthma control by physicians and the need to step-up therapy.…”

Section: Composite Asthma Scoresmentioning

confidence: 99%

Clinical Tools to Assess Asthma Control in Children

Dinakar¹,

Chipps²,

Allergy³

2017

Pediatrics

View full text Add to dashboard Cite

Asthma affects an estimated 7 million children and causes significant health care and disease burden. The most recent iteration of the National Heart, Lung and Blood Institute asthma guidelines, the Expert Panel Report 3, emphasizes the assessment and monitoring of asthma control in the management of asthma. Asthma control refers to the degree to which the manifestations of asthma are minimized by therapeutic interventions and the goals of therapy are met. Although assessment of asthma severity is used to guide initiation of therapy, monitoring of asthma control helps determine whether therapy should be maintained or adjusted. The nuances of estimation of asthma control include understanding concepts of current impairment and future risk and incorporating their measurement into clinical practice. Impairment is assessed on the basis of frequency and intensity of symptoms, variations in lung function, and limitations of daily activities. “Risk” refers to the likelihood of exacerbations, progressive loss of lung function, or adverse effects from medications. Currently available ambulatory tools to measure asthma control range are subjective measures, such as patient-reported composite asthma control score instruments or objective measures of lung function, airway hyperreactivity, and biomarkers. Because asthma control exhibits short- and long-term variability, health care providers need to be vigilant regarding the fluctuations in the factors that can create discordance between subjective and objective assessment of asthma control. Familiarity with the properties, application, and relative value of these measures will enable health care providers to choose the optimal set of measures that will adhere to national standards of care and ensure delivery of high-quality care customized to their patients.

show abstract

Childhood Asthma Control Test and airway inflammation evaluation in asthmatic children

Abstract: This study confirms and expands the concept that C-ACT is complementary to, but not a substitute for, other markers of disease control in asthmatic children, especially in the context of follow-up visits.

Cited by 53 publications

References 35 publications

Asthma Control Assessment Tools

Asthma Control Assessment Tools

The Interpretation of Exhaled Nitric Oxide Values in Children With Asthma Depends on the Degree of Bronchoconstriction and the Levels of Asthma Severity

Clinical Tools to Assess Asthma Control in Children

Contact Info

Product

Resources

About