Childhood bullous pemphigoid: Immunohistochemical, immunoelectron microscopic, and Western blot analysis

Nagano, Toru; Tani, Masahiro; Adachi, Atsuko; Takanaga, Tetsuya; Sakamoto, Sachiko; Kodama, Satoru; Fujiwara, Sakuhei

doi:10.1016/s0190-9622(94)70106-7

Cited by 31 publications

(10 citation statements)

References 17 publications

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“…In the literature, all mothers of BP infants were healthy without a medical history of bullous disease. In six cases, mothers' sera were tested to circulating BP180 antibodies, but only by IIF, a low sensitivity method, and they were found to be negative 9,11 , 12,14 , 17,18 …”

Section: Discussionmentioning

confidence: 99%

Absence of anti-BP180 antibodies in mothers of infants with bullous pemphigoid

Chiavérini¹,

Hamel‐Teillac²,

Gilbert³

et al. 2005

British Journal of Dermatology

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Section: Discussionmentioning

confidence: 99%

Absence of anti-BP180 antibodies in mothers of infants with bullous pemphigoid

Chiavérini¹,

Hamel‐Teillac²,

Gilbert³

et al. 2005

British Journal of Dermatology

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“…It is known that BP in children is a true variant of the adult form of the disease (Nagano et al 1994). A review found 50 cases of childhood BP in the literature that had been confirmed by direct and indirect immunofluorescence (Fisler et al 2003).…”

Section: Bullous Pemphigoidmentioning

confidence: 99%

Non‐Infective Cutaneous Conditions of the Vulva

Neill

Lewis

2009

Ridley's the Vulva

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“…However, they did not include the findings of split skin or immunoblot analysis, as these investigations had not been carried out in the cases reviewed, and this series included at least one of our patients with inflammatory childhood EBA (2). Since then several additional cases of childhood BP have been reported (14)(15)(16)(17)(18)(19)(20). Some of these reports have included the findings of immunoblotting, split skin IMF, and immunoelectron micros-COPY.…”

Section: Discussionmentioning

confidence: 99%

Bullous Pemphigoid and Epidermolysis Bullosa Acquisita: Presentation, Prognosis, and Immunopathology in 11 Children

Edwards¹,

Wakelin

Wojnarowska

et al. 1998

Pediatric Dermatology

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The immunobullous diseases bullous pemphigoid (BP) and epidermolysis bullosa acquisita (EBA) are very rare in childhood. Although case studies have been detailed, there are no reports of a large series of patients documenting the effectiveness of treatment and longterm prognosis. We report the clinical presentation, immunopathologic features, disease course, and long-term prognosis of BP and EBA in a series of 11 children. The initial diagnoses based on clinical features were BP (5), EBA (3), and chronic bullous disease of childhood (CBDC) (3).These were subsequently revised from BP to EBA (2), CBDC to BP (2), and CBDC to BP or EBA (1) following the results of direct and indirect immunofluorescence and immunoblotting. Analysis of IgG subclasses in eight cases showed that the predominant subclasses were lgGl (8) and lgG4 (6). The clinical features appeared to be highly variable, and in patients presenting with inflammatory blistering, laboratory studies were required in order to differentiate between BP and EBA. All patients improved on treatment with corticosteroids andlor sulfones, although treatment regimens showed wide variation. Their diseases tended to remit within 2 years, and their long-term prognosis was good.

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Childhood bullous pemphigoid: Immunohistochemical, immunoelectron microscopic, and Western blot analysis

Cited by 31 publications

References 17 publications

Absence of anti-BP180 antibodies in mothers of infants with bullous pemphigoid

Absence of anti-BP180 antibodies in mothers of infants with bullous pemphigoid

Non‐Infective Cutaneous Conditions of the Vulva

Bullous Pemphigoid and Epidermolysis Bullosa Acquisita: Presentation, Prognosis, and Immunopathology in 11 Children

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