Childhood cancer survivor cohorts in Europe

Winther, Jeanette Falck; Kenborg, Line; Byrne, Julianne; Hjorth, Lars; Kaatsch, Peter; Kremer, Leontien C. M.; Kuehni, Claudia E.; Auquier, Pascal; Gautier, Michel; Vathaire, Florent de; Haupt, Riccardo; Skinner, Roderick; Madanat‐Harjuoja, Laura; Tryggvadóttír, Laufey; Wesenberg, Finn; Reulen, Raoul C.; Grabow, Desiree; Ronckers, Cécile M.; Broeder, Eline van Dulmen‐den; Heuvel‐Eibrink, Marry M. van den; Schindler, Matthias; Berbis, Julie; Holmqvist, Anna Sällfors; Guðmundsdóttir, Þorgerður; Licht, Sofie de Fine; Bonnesen, Trine Gade; Asdahl, Peter H.; Bautz, Andrea; Kristoffersen, Anja K; Himmerslev, Liselotte; Hasle, Henrik; Olsen, Jørgen H.; Hawkins, Mike

doi:10.3109/0284186x.2015.1008648

Cited by 113 publications

(96 citation statements)

References 34 publications

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“…In the developed countries today, a majority ($80%) will survive their primary malignancy [1]. Cure is nonetheless uncertain and treatment is typically intense, invasive and given for several months or years.…”

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confidence: 99%

Impact of a child’s cancer disease on parents’ everyday life: a longitudinal study from Sweden

et al. 2016

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Background: A child's cancer disease may disrupt the daily life of the affected family for a long period. The aim was to describe restrictions on parents' leisure activities and work/studies during and after the child's treatment. Methods: This study used data from a cohort of mothers and fathers (n ¼ 246) of children diagnosed with cancer. Data was collected five times from two months after diagnosis to one year after end of treatment. Reports of restrictions were evaluated over time, between mothers and fathers, and in relation to parent-reported child symptom burden (The Memorial Symptom Assessment Scale) and partial post-traumatic stress disorder (PTSD) (The PTSD Checklist-Civilian Version). Results: Two (51%) and four (45%) months after diagnosis, about half reported that their leisure activities were restricted at least some of the time. Corresponding percentages for restrictions on work/ studies were 84% and 77%. One year after end of treatment, the great majority reported that their leisure activities (91%) and/or work/studies (76%) were never/seldom restricted. During treatment, more mothers than fathers reported restrictions on work/studies all/most of the time. After end of treatment, gender was only related to reports of restrictions among parents not reporting partial PTSD. More parents who reported being restricted all/most of the time also reported partial PTSD and/or a greater symptom burden for the child. Conclusion: Parents report frequent restrictions on everyday life during treatment. One year after end of treatment, parents report only a limited impact of the child's cancer on their leisure activities and work/studies. More parents who report restrictions also report partial PTSD and/or a greater child symptom burden. The effect of gender on restrictions varies depending on reports of partial PTSD. Future studies of gender differences regarding the impact of a child's cancer on parents' everyday life should thus consider mothers' and fathers' level of psychological distress.

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confidence: 99%

Impact of a child’s cancer disease on parents’ everyday life: a longitudinal study from Sweden

et al. 2016

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“…Paediatric cancer is still a major public health issue, despite high survival rates compared to adult cancers  Each year there are 35,000 new cases of cancer in children and adolescents in Europe (15,000 in children below the age of 15 years and 20,000 in those aged [15][16][17][18][19][20][21][22][23][24].  1 out of 300 new-borns will develop cancer before turning 20.…”

Section: Cancer In Young People In Europementioning

confidence: 99%

“…Two ongoing FP7 European projects, PanCareSurFup and PanCareLIFE, carry out research on late-occurring side effects [17]. The pilot initiative of the 'Survivorship Passport' is being developed thanks to the support of ENCCA and PanCareSurFup, and the organisation of care…”

Section: Actionsmentioning

confidence: 99%

The SIOPE strategic plan: A European cancer plan for children and adolescents

Vassal

Schrappe

Pritchard‐Jones

et al. 2016

Journal of Cancer Policy

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Executive summaryCancer in young people is rare, but it is still a major health issue in Europe. Each year, more than 6,000 young people in Europe die of cancer. There are more than 300,000 European childhood cancer survivors (in 2020, they will be nearly half a million): two-thirds of them have some late side effects of treatment, that are severe and impact on the daily life of half of those affected.Within the European Network for Cancer research in Children and Adolescents (ENCCA), SIOPE and the European paediatric haematology-oncology community have established a long-term sustainable Strategic Plan to increase the cure rate and the quality of survivorship for children and young people with cancer over the next ten years. The ultimate goal is to increase the disease-and late-effect-free survival after 10 years from the diagnosis, and beyond.

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“…As with adult cancer patients, childhood cancer patients decrease their physical activity levels during and after cancer treatment, which may exacerbate LAE [10,17,36,38]. Physical activity is positively related to body weight management, cardiopulmonary fitness, musculoskeletal integrity, mental well-being, and decreased risk of premature mortality in adult cancer patients [38], while reduced physical activity is associated with decreased cardiopulmonary function, aerobic fitness, and motor-skill development/integrity and increased cachexia and cancer-related fatigue [18].…”

Section: Introductionmentioning

confidence: 99%

“…Survivors of childhood cancer are also at increased risk for neurocognitive and neurosensory impairment including ocular degeneration, hearing loss and neuropathy [28][29][30][31], metabolic disturbances (abnormal blood counts, liver and kidney dysfunction, and osteoporosis) [28][29][30]32,33], transfusion-associated infections [30], and increased risk of subsequent neoplasm [14]. A major concern is that chronic LAE may increase in frequency and severity over time, and interact adversely with the normal ageing process, resulting in increasing and clinically significant impairment of vital organ systems during adulthood at a younger age than normal, and an increased risk of premature major illness or death [34][35][36][37].…”

Section: Introductionmentioning

confidence: 99%

The Role of Exercise in Pediatric and Adolescent Cancers: A Review of Assessments and Suggestions for Clinical Implementation

Klika

Tamburini

Galanti

et al. 2018

JFMK

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Abstract:In the European Union, five-year survival rates for childhood cancer patients are approaching 72-80%, which is a testament to better diagnostics and improved treatment. As a result, a large proportion of childhood cancer patients go on to live productive lives well past reproductive age. While this is encouraging, childhood cancer treatment is accompanied by multiple long-term adverse effects on physical and mental wellbeing. While there are several approaches to address mental health, reproductive integrity, secondary pathologies, and recurrence, in order to optimize quality of life in childhood cancer patients, exercise and nutrition should also be considered. It is clear that physical activity plays an important role in the prevention and reduction of long-term adverse side effects associated with cancer treatment in both children and adults. However, the current exercise guidelines for cancer survivors are based on adult data and accordingly are not appropriate for children. As children and adults are markedly different, including both the pathophysiology of cancer and exercise response, treatment plans incorporating exercise for children should be age-specific and individually tailored to both reduce the development of future comorbidities and enhance physical health. The purpose of this paper is to review the predominant cancer types and effects of cancer treatment in children, describe several special considerations, and propose a framework for assessment and exercise guidelines for this population.

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Childhood cancer survivor cohorts in Europe

Cited by 113 publications

References 34 publications

Impact of a child’s cancer disease on parents’ everyday life: a longitudinal study from Sweden

Impact of a child’s cancer disease on parents’ everyday life: a longitudinal study from Sweden

The SIOPE strategic plan: A European cancer plan for children and adolescents

The Role of Exercise in Pediatric and Adolescent Cancers: A Review of Assessments and Suggestions for Clinical Implementation

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