Childhood central nervous system tumors at MAHAK’s Pediatric Cancer Treatment and Research Center (MPCTRC), Tehran, Iran

Mehrvar, Azim; Faranoush, Mohammad; Asl, Amir Abbas Hedayati; Tashvighi, Maryam; Fazeli, Mohammad Ali; Qaddoumi, Ibrahim; Mehrvar, Narjes; Sobuti, Behdad; Jafarpour, Ali; parsa, Reza Ravan; Zangooei, Rokhsaneh; Alebouyeh, Mardawig; Vossough, Parvaneh

doi:10.1007/s00381-013-2256-8

Cited by 15 publications

(16 citation statements)

References 14 publications

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“…Two articles were written in Persian [8, 12], whereas the remaining 33 were written in English. Most studies (n = 27) took place in Tehran province [4–5, 8, 11–13, 15–23, 25–29, 31–37] in hospitals and centers affiliated with the three main medical universities in Tehran: Tehran University of Medical Sciences (n = 16) [4–5, 11, 13, 16–17, 19–22, 26, 28–29, 31–32, 37], Shahid Beheshti University of Medical Sciences (n = 6) [12, 15, 18, 25, 27, 34,], Iran University of Medical Sciences (n = 4) [8, 23, 35, 36], and Army University of Medical Science (n = 1) [33]. Only four articles [18, 23, 26, 34] stated that approval by an ethics committee had been obtained.…”

Section: Resultsmentioning

confidence: 99%

“…The study objectives were categorized as clinical (n = 18 articles, 173 patients), epidemiologic (n = 9 articles [5, 8, 12–13, 16, 26, 28, 33–34], 1,881 patients), pathologic (n = 4 articles [11, 14, 15, 18], 1,160 patients), genetic (n = 2 articles [7, 30], 75 patients), surgical (n = 1 article [21], 172 patients), or radiologic (n = 1 article [29], 23 patients). Study designs were primarily single case reports (n = 16 articles [2–4, 9, 16–17, 19–22, 24, 29, 31–32, 36–37], 19 patients) and cross-sectional studies (n = 15 articles [7–8, 10–14, 15, 18, 25–26, 28, 30, 33–34], 3,271 patients).…”

Section: Resultsmentioning

confidence: 99%

“…Study designs were primarily single case reports (n = 16 articles [2–4, 9, 16–17, 19–22, 24, 29, 31–32, 36–37], 19 patients) and cross-sectional studies (n = 15 articles [7–8, 10–14, 15, 18, 25–26, 28, 30, 33–34], 3,271 patients). Other study designs included cohort (n = 2 articles [23, 35], 131 patients), case series (n = 1 article [5], 7 patients), and case control (n = 1 article [27], 56 patients) (Table 1).…”

Section: Resultsmentioning

confidence: 99%

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Comprehensive analysis of Iranian reports of pediatric central nervous system tumors

Mehrvar

Akbari

et al. 2017

Childs Nerv Syst

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Purpose Iran lacks a national registry reporting the data of central nervous system (CNS) tumors in children. Consequently, treatment success and failure rates are unknown, and a centralized system for disease-management recommendations does not exist. Methods To critically evaluate the current state of pediatric CNS tumor studies and reporting in Iran, we performed an extensive retrospective analysis of all known reports identified with multiple search engines. Results Of 409 initially retrieved articles, we evaluated 123 matching our inclusion criteria. We further narrowed these reports to 74 by excluding studies pertaining to adult patients only, non-CNS tumors, or brain metastases. We also excluded studies that were performed outside of Iran or that did not contain relevant data from our analysis. We divided the remaining studies into those describing exclusively pediatric patients (3,484 patients) and those describing mixed populations of adults and children (18,641 patients). In total, our analysis included 22,125 patients. Conclusions We identified many limitations in the reporting of studies describing the treatment or prevalence of CNS tumors in children in Iran. Our results may guide future efforts in Iran to improve the care for children with CNS tumors and may provide a valuable template for other comprehensive country- and disease-specific retrospective analyses.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Comprehensive analysis of Iranian reports of pediatric central nervous system tumors

Mehrvar

Akbari

et al. 2017

Childs Nerv Syst

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“…For example, one of the most distinguished and successful pain departments is at MAHAK hospital, which focuses on pediatric cancer pain. Many different types of cancer have been reported in children admitted to MAHAK’S Pediatric Cancer Treatment and Research Center (MPCTRC) including acute lymphocytic leukemia (ALL), acute myelocytic leukemia (AML) [25], central nervous system tumors such as primitive neuroectodermal tumor (PNET) [26], and soft and hard tissue tumors [27]. …”

Section: Discussionmentioning

confidence: 99%

“…Other interventional pain management techniques accessible at this center include the use of radiofrequency and microwave for modulation, ablation, and coagulation of pain pathways, implantable analgesic pumps in the epidural or intrathecal space, along with botulinum toxin injection therapy (for headaches, muscle pains, and spasms), photodynamic therapy, aromatherapy, and music therapy [28]. There are many disease-based projects undertaken at this center [25–28]. There are also a number of ongoing projects investigating the follow-up of cancer patients since 2014, which are due to be completed by 2020.…”

Section: Discussionmentioning

confidence: 99%

Encountering a Neglected Area of a Healthcare System: A Decade of Improvement in Cancer Pain Clinical Practice in Iran

2016

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BackgroundWith the increase in the prevalence of cancer, cancer-related issues also deserve more attention especially in developing countries where there is already limited access to high-quality healthcare. Cancer-related pain, the most common and the most annoying one, is not only a symptom but also an important subspecialty and its management is still challenging.ObjectivesTo assess the level of pain and cancer pain knowledge in Iran in comparison with the whole world.Materials and MethodA search of the literature including papers published in PubMed before March 2016 was carried out.ResultsThere have been an increasing number of publications on pain since 1842 and a growing number of publications on cancer pain since 1929. There has also been remarkable growth in our understanding of cancer pain, particularly since 2010. More than one-third of studies on pain and cancer-related pain were published after 2010.ConclusionThere is a need to be more inventive with the management of cancer-related issues, especially pain in developing countries, to maximize the quality and quantity of healthcare delivery to cancer-stricken patients. It seems that non-governmental organizations like MAHAK can play a significant role in this goal.

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Creation of a successful multidisciplinary course in pediatric neuro‐oncology with a systematic approach to curriculum development

Moreira

Gajjar

Patay

et al. 2020

Cancer

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Background The St Jude Global Academy Neuro‐Oncology Training Seminar (NOTS) is a hybrid course in pediatric neuro‐oncology specifically designed for physicians from low‐income and middle‐income countries. Methods The curriculum for the course was created by conducting a targeted needs assessment that evaluated 11 domains of care for children with central nervous system (CNS) tumors. The targeted needs assessment was completed by 24 institutions across the world, and the data were used to define 5 core elements included in the 2 components of the NOTS: a 9‐week online course and a 7‐day in‐person workshop. Participant acquisition of knowledge and changes in clinical behavior were evaluated as measures of success. Results Teams from 8 institutions located in 8 countries enrolled in the online course, and it was successfully completed by 36 participants representing 6 specialties. On the basis of their performance in the online course, 20 participants from 7 institutions took part in the on‐site workshop. The participants exhibited improved knowledge in core elements of treating children with CNS tumors, including barriers of care, possible solutions, and steps for project implementation (P < .0001). All participants expressed a belief that they acquired new concepts and knowledge, leading to changes in their clinical practice. Those present at the workshop created an international multidisciplinary group focused on treating CNS tumors in low‐income and middle‐income countries. Conclusions By using a hybrid online and in‐person approach, the authors successfully created a multidisciplinary course focused on pediatric CNS tumors for resource‐limited settings. Their experience supports this strategy as a feasible mechanism for driving further global collaborations.

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Childhood central nervous system tumors at MAHAK’s Pediatric Cancer Treatment and Research Center (MPCTRC), Tehran, Iran

Abstract: In contrast of high rate of death in this study, other general characteristics can serve as benchmark for improving our care for children with brain tumors in Iran.

Cited by 15 publications

References 14 publications

Comprehensive analysis of Iranian reports of pediatric central nervous system tumors

Comprehensive analysis of Iranian reports of pediatric central nervous system tumors

Encountering a Neglected Area of a Healthcare System: A Decade of Improvement in Cancer Pain Clinical Practice in Iran

Creation of a successful multidisciplinary course in pediatric neuro‐oncology with a systematic approach to curriculum development

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