Childhood chromium exposure and neuropsychological development in children living in two polluted areas in southern Spain

Caparrós-González, Rafael A.; Giménez-Asensio, María José; Gónzalez-Alzaga, Beatriz; Aguilar-Garduño, Clemente; Lorca-Marín, José Andrés; Alguacil, Juan; Becerra, Inmaculada Gómez; Gómez-Ariza, José Luis; García-Barrera, Tamara; Hernández, Antonio F.; López-Flores, Inmaculada; Rohlman, Diane S.; Romero-Molina, Desirée; Ruíz-Pérez, Isabel; Lacasaña, Marina

doi:10.1016/j.envpol.2019.06.084

Cited by 42 publications

(20 citation statements)

References 53 publications

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“…We followed a group of pregnant women from the first trimester, through pregnancy, birth, and postpartum until their infants were six months of age. Because maternal level of education, salary, and infant birth weight have been deemed relevant when evaluating infant neurodevelopment [5,32,33], these variables were included as covariates in further analyses. Our results suggested that maternal hair cortisol levels and neonatal hair cortisol levels could predict infant neurodevelopment at the age of six months.…”

Section: Discussionmentioning

confidence: 99%

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Maternal and Neonatal Hair Cortisol Levels Are Associated with Infant Neurodevelopment at Six Months of Age

Caparrós-González

Romero-González

González-Pérez

et al. 2019

JCM

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Background: Maternal stress during pregnancy can affect fetal development during certain sensitive periods. Objective: To longitudinally assess maternal hair cortisol levels during pregnancy, and the postpartum along with neonatal hair cortisol levels that could be associated with infant neurodevelopment at six months of age. Methods: A sample of 41 pregnant women longitudinally assessed during the first, second, and third trimester and the postpartum, along with their 41 full-term neonates participated in this study. Hair cortisol levels were assessed from participants. Infant neurodevelopment was assessed by means of the Bayley Scale of Infants Development, Third Edition at age six months. Results: Maternal hair cortisol levels in the first and second trimester accounted for 24% and 23%, respectively, of variance of infant gross motor development (p < 0.05). Maternal hair cortisol levels during the postpartum accounted for 31% of variance of infant cognitive development (p < 0.05), and 25% of variance of infant gross motor development (p < 0.05). Neonatal hair cortisol levels accounted for 28% of variance of infant gross motor development (p < 0.05). Conclusions: The preconception and prenatal time are sensitive periods related to infant neurodevelopment along with the cortisol levels surrounding the fetus while in the womb. Pregnant women could be assessed for hair cortisol levels while attending a prenatal appointment.

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Section: Discussionmentioning

confidence: 99%

“…Maternal level of education and salary have been reported to be associated with infant’s neurodevelopment in previous studies [32,33]. Infant birthweight is a major factor associated with long-term development [5,34].…”

Section: Methodsmentioning

confidence: 99%

Maternal and Neonatal Hair Cortisol Levels Are Associated with Infant Neurodevelopment at Six Months of Age

Caparrós-González

Romero-González

González-Pérez

et al. 2019

JCM

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“…This element is 17that the ATSDR list 10 as human carcinogenic and associated with neurological and developmental disorders. 22,23 The main source of children's exposure to cadmium, beside water and food consumption, is associated with chewing and ingestion of inedible materials. 22 Antimony has a wide range of industrial applications including electronics, plastics and pants production.…”

Section: Accepted Manuscriptmentioning

confidence: 99%

Toxic elements in children’s crayons and colored pencils: Bioaccessibility assessment

Djogo-Mracevic

Ražić

Trisic³

et al. 2022

JSCS

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Crayons and colored pencils for children may contain toxic elements (TEs) exhibiting potential risk for children?s health including cognitive development, after their ingestion, through mouthing and chewing and eventually, their accumulation. The aim of this study was to determine total content of As, Pb, Cr, Cd, Ni, and Sb and estimate their bioaccessibility conducting artificial saliva extraction. Sixty samples of colored pencils and crayons from 10 manufacturers were analyzed. Microwave acid assisted digestion followed by inductively coupled plasma optical spectroscopy (ICP-OES) was performed for determination of total content of TE. Simulation of extraction by artificial saliva was applied to get more reliable data when bioavailability is concerned. The total concentrations of TE were higher in colored pencils than in crayons and their maximum levels were: 5.78, 9.36, 9.97, 0.615, and 6.63 mg kg-1 for As, Pb, Cr, Cd, and Ni respectively. Concentration of Sb was below the detection limit for all investigated samples. This study showed that concentration of As and Pb in several samples did not comply with European Union regulative. Bioaccessibility study showed the high degree of leaching of Cr and As from pencils, but regardless of extracted portions, concentrations of selected investigated TE were below allowed levels.

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“…High Cr exposure in adults generally occurs through working in tanneries, as a machinist, or in printing [54]; however, the study participants would unlikely to be working in such environments. One recent cross-sectional study found an association between Cr and neuropsychological problems in children [55]. Further research is required to understand the effects on behavior, if any.…”

Section: Behavioral Problems and Heavy Metal Levelsmentioning

confidence: 99%

Exposure to Toenail Heavy Metals and Child Behavior Problems in Nine-Year-Old Children: A Cross-Sectional Study

Karatela

Coomarasamy

Paterson

et al. 2020

IJERPH

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Behavioral problems are multifactorial and includes perinatal, maternal, family, parenting, socio-economic and personal risk factors, but less is known about the association of postnatal heavy metals on children’s behavioral problems in Pacific Island children. Methods: A cohort of eligible nine-year-old children within a Pacific Island Families longitudinal study were recruited for a cross-sectional study. Child behavior problems were assessed using the child behavior checklist. Heavy metals (including Ni, Cu, Pb, Al, Cr and Cd) were determined in toenails, after acid digestion and analyzed using inductively coupled plasma mass spectrometry. Other factors such as lifestyle (smoking in pregnancy), health outcomes (obesity, health status), demographics (gender, ethnicity, parents’ marital status) and socioeconomic status (household income levels) were also collected. The statistical analysis included t-tests for independent sample and Mann–Whitney U-test, and chi-square or Fisher’s exact tests of independence for comparisons of the proportions. Regression models tested the hypothesized risk factors for behavior outcomes. Results: This observational study enrolled 278 eligible Pacific Island children living in Auckland, New Zealand. The prevalence of behavioral problems in the clinical range was high (22%) but there was no significant association between heavy metals in toenails and adverse behavioral outcomes. Conclusion: Regular monitoring and assessments of children for environmental risk factors, as well as social and lifestyle factors for behavior problems, continues. Alternative indicators of exposure to heavy metal should be evaluated.

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Childhood chromium exposure and neuropsychological development in children living in two polluted areas in southern Spain

Cited by 42 publications

References 53 publications

Maternal and Neonatal Hair Cortisol Levels Are Associated with Infant Neurodevelopment at Six Months of Age

Maternal and Neonatal Hair Cortisol Levels Are Associated with Infant Neurodevelopment at Six Months of Age

Toxic elements in children’s crayons and colored pencils: Bioaccessibility assessment

Exposure to Toenail Heavy Metals and Child Behavior Problems in Nine-Year-Old Children: A Cross-Sectional Study

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