Childhood chronic inflammatory demyelinating polyneuroradiculopathy – Three cases and a review of the literature

Systematic review of immunoglobulin use in paediatric neurological and neurodevelopmental disorders

“…In summary, the evidence shows that a good response to initial treatment with IVIG occurred in 78% ( n =59), corticosteroids in 70% ( n =44), and plasma exchange in 14% ( n =7) …”

“…Three further series ( n =7) found good response with first‐line IVIG in 71%, which specifically improved sensory or motor function. Further treatment was required in 40% of responders . A series ( n =2) of patients with childhood multiple sclerosis on interferon who were subsequently diagnosed with CIDP had a limited response to steroids but a good response to IVIG …”

“…Further treatment was required in 40% of responders. [32][33][34] A series (n=2) of patients with childhood multiple sclerosis on interferon who were subsequently diagnosed with CIDP had a limited response to steroids but a good response to IVIG. 35 In summary, the evidence shows that a good response to initial treatment with IVIG occurred in 78% (n=59), corticosteroids in 70% (n=44), and plasma exchange in 14% (n=7).…”

“…35 In summary, the evidence shows that a good response to initial treatment with IVIG occurred in 78% (n=59), corticosteroids in 70% (n=44), and plasma exchange in 14% (n=7). [27][28][29][30][31][32][33][34][35] What this paper adds • Studies demonstrating intravenous immunoglobulin efficacy are available in a wide range of neurodevelopmental and childhood neuroinflammatory conditions.…”

Chronic Inflammatory Demyelinating Polyneuropathy in Children: A Review of Clinical Characteristics and Recommendations for Treatment

“…Steroids induced short-term improvement in 71% -100% of children in small series (63). As a first-line therapy, oral prednisone is usually administered at a dose of 1 -2 mg/kg/day in the initial four to six weeks, then reduced over the next four to six weeks (45,64), or even by tapering over 3 -6 months.6 Interval therapy (2 mg/kg/day for 3 -8 days, repeated every four weeks) and also alternating therapy (2 mg/kg/alternate day) have been designated (58,65). In some patients, high-dose 'pulse' methylprednisolone therapy (15 -20 mg/kg/day for three days) was intravenously administered before the origination of oral prednisone therapy (31,33,48).…”