Childhood cognitive ability and risk of late-onset Alzheimer and vascular dementia

McGurn, Brian; Deary, Ian J.; Starr, John M.

doi:10.1212/01.wnl.0000319692.20283.10

Cited by 112 publications

(82 citation statements)

References 35 publications

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“…First, VP/VLBW birth is related to brain injuries that affect brain organization [28][29] and second, neonatal complications and mechanical ventilation in particular have been shown to lead to alterations in brain structure with adverse effects on cognitive functioning [30]. Even small IQ differences are important as they are not only related -as shown here -to HRQoL, but also to socioeconomic status and even reduced survival and health into old age [31][32].…”

Section: Discussionmentioning

confidence: 79%

Neonatal treatment philosophy in Dutch and German NICUs: health-related quality of life in adulthood of VP/VLBW infants

et al. 2016

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Section: Discussionmentioning

confidence: 79%

Neonatal treatment philosophy in Dutch and German NICUs: health-related quality of life in adulthood of VP/VLBW infants

et al. 2016

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“…In support of this, previous evidence indicates that the effect on total dementia is driven by associations with vascular dementia and not Alzheimer's disease. 54 Furthermore, that risk of dementia mortality relates to premorbid intelligence for late onset but not early onset cases 55which tend to have a higher genetic component-might implicate health behaviours and lifestyle factors.…”

Section: No Of Peoplementioning

confidence: 99%

Childhood intelligence in relation to major causes of death in 68 year follow-up: prospective population study

Calvin

Batty

Der

et al. 2017

BMJ

160

137

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Objectives To examine the association between intelligence measured in childhood and leading causes of death in men and women over the life course. Design Prospective cohort study based on a whole population of participants born in Scotland in 1936 and linked to mortality data across 68 years of follow-up. Setting Scotland. Participants 33 536 men and 32 229 women who were participants in the Scottish Mental Survey of 1947 (SMS1947) and who could be linked to cause of death data up to December 2015. Main outcome measures Cause specific mortality, including from coronary heart disease, stroke, specific cancer types, respiratory disease, digestive disease, external causes, and dementia. Results Childhood intelligence was inversely associated with all major causes of death. The age and sex adjusted hazard ratios (and 95% confidence intervals) per 1 SD (about 15 points) advantage in intelligence test score were strongest for respiratory disease (0.72, 0.70 to 0.74), coronary heart disease (0.75, 0.73 to 0.77), and stroke (0.76, 0.73 to 0.79). Other notable associations (all P<0.001) were observed for deaths from injury (0.81, 0.75 to 0.86), smoking related cancers (0.82, 0.80 to 0.84), digestive disease (0.82, 0.79 to 0.86), and dementia (0.84, 0.78 to 0.90). Weak associations were apparent for suicide (0.87, 0.74 to 1.02) and deaths from cancer not related to smoking (0.96, 0.93 to 1.00), and their confidence intervals included unity. There was a suggestion that childhood intelligence was somewhat more strongly related to coronary heart disease, smoking related cancers, respiratory disease, and dementia in women than men (P value for interactions <0.001, 0.02, <0.001, and 0.02, respectively).Childhood intelligence was related to selected cancer presentations, including lung (0.75, 0.72 to 0.77), stomach (0.77, 0.69 to 0.85), bladder (0.81, 0.71 to 0.91), oesophageal (0.85, 0.78 to 0.94), liver (0.85, 0.74 to 0.97), colorectal (0.89, 0.83 to 0.95), and haematopoietic (0.91, 0.83 to 0.98). Sensitivity analyses on a representative subsample of the cohort observed only small attenuation of the estimated effect of intelligence (by 10-26%) after adjustment for potential confounders, including three indicators of childhood socioeconomic status. In a replication sample from Scotland, in a similar birth year cohort and follow-up period, smoking and adult socioeconomic status partially attenuated (by 16-58%) the association of intelligence with outcome rates. Conclusions In a whole national population year of birth cohort followed over the life course from age 11 to age 79, higher scores on a well validated childhood intelligence test were associated with lower risk of mortality ascribed to coronary heart disease and stroke, cancers related to smoking (particularly lung and stomach), respiratory diseases, digestive diseases, injury, and dementia.

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“…[1][2][3][4]6,42 In the general population, low childhood IQ has been found to predict low adult SES, 43,44 as well as reduced survival and health into old age. 45,46 IQ is thus an important marker of brain health. 47 Yet, as far as we are aware, this is the first prospective study report on the change and stability of cognitive function into adulthood (26 years of age) on a whole population sample of VP/VLBW individuals.…”

Section: Figurementioning

confidence: 99%

Preterm Cognitive Function Into Adulthood

Breeman¹,

Jaekel

Baumann³

et al. 2015

Pediatrics

168

155

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, Dieter Wolke, PhD, Dr rer nat hc a,d abstract BACKGROUND: Very preterm (VP; gestational age ,32 weeks) and very low birth weight (VLBW; ,1500 g) births are related to impaired cognitive function across the life span. It is not known how stable cognitive functions are from childhood to adulthood for VP/VLBW compared with term-born individuals and how early adult cognitive function can be predicted.

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Childhood cognitive ability and risk of late-onset Alzheimer and vascular dementia

Cited by 112 publications

References 35 publications

Neonatal treatment philosophy in Dutch and German NICUs: health-related quality of life in adulthood of VP/VLBW infants

Neonatal treatment philosophy in Dutch and German NICUs: health-related quality of life in adulthood of VP/VLBW infants

Childhood intelligence in relation to major causes of death in 68 year follow-up: prospective population study

Preterm Cognitive Function Into Adulthood

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