Childhood development and adult longevity in an archaeological population from Barton-upon-Humber, Lincolnshire, England

Watts, Rebecca

doi:10.1016/j.ijpp.2013.05.001

Cited by 65 publications

(45 citation statements)

References 70 publications

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“…Only juveniles in this study have active CO and PH; this is the result of when these lesions form. CO and PH typically develop in individuals between 6 months and 12 years of age (Blom et al, ; DeWitte & Slavin, ; Watts, ). Further, most individuals who have active CO or PH are juveniles less than 5 years old (Fairgrieve & Molto, ; Larsen, ; Mittler & Van Gerven, ; Šlaus, ).…”

Section: Discussionmentioning

confidence: 99%

“…Physiological disturbances suffered in early life have been shown to be related to increased mortality risks, earlier ages of death, and increased disease load in adulthood (Armelagos, Goodman, Harper, & Blakey, ; Barker, ; Barker et al, ; Barker & Osmond, ; Barker, Osmond, & Law, ; DeWitte, ). Bioarchaeological studies have linked early mortality with the presence of skeletal and dental indicators of stress (Armelagos et al, ; Boldsen, ; DeWitte, ; Temple, ), smaller vertebral canal sizes (Clark et al, ; Watts, ), as well as shorter achieved stature in adults (Kemkes‐Grottenthaler, ). While indicators of early stress have been linked with increased morbidity and mortality, a survival advantage has been linked to healed periosteal lesions (DeWitte, ; Ham, ; Usher, ; Wood, Milner, Harpending, & Weiss, ).…”

Section: Introductionmentioning

confidence: 99%

“…Juvenile bone marrow is more reactive than that of adults; resulting in more severe skeletal responses to lesser stimuli (Lewis, , p. 193). Due to this physiology, CO and PH lesions typically form during the first years of life (Blom et al, ; DeWitte & Slavin, ; Jackes, Lubell, & Meiklejohn, ; Watts, ). However, healed CO and PH lesions (from childhood) are often present and visible throughout adulthood (Lallo, Armelagos, & Mensforth, ; Roberts & Manchester, ; Stuart‐Macadam, ).…”

Section: Introductionmentioning

confidence: 99%

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Indicators of stress and their association with frailty in the precontact Southwestern United States

O’Donnell

2019

American J Phys Anthropol

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Objectives: Physiological disturbances in early life have been shown to increase individual mortality risk and impact health in adulthood. This study examines frailty through analysis of lesion status of two commonly collected skeletal indicators of stress (cribra orbitalia [CO] and porotic hyperostosis [PH]) and their association with mortality risk in the precontact U.S. Southwest. Several predictions are addressed: (a) individuals with active skeletal lesions are the frailest; (b) individuals with healed lesions are the least frail; (c) CO lesions, regardless of status, are associated with increased mortality risk. Materials and methods: Odds ratios and Kaplan-Meier survival analysis are used to examine the association between stress indicators and mortality in the U.S. Southwest. This study includes 335 individuals (75 females, 81 males, 20 adults of unknown sex, and 159 juveniles) from precontact New Mexico archaeological sites dating to A.D. 1,000-1,400. Results: Active CO and PH lesions are associated with lower survivorship and greater mortality risk than healed or absent lesions. Only juvenile individuals have active CO and PH lesions, as is expected given their physiology. CO lesions in any state are associated with greater mortality risk and earlier ages of death. Discussion: Individuals with active lesions are the frailest; while individuals with healed lesions are the least frail. CO and PH likely have different etiologies: CO lesions are associated with increased mortality risk and decreased individual longevity. These results indicate that CO's presence suggests a more severe underlying condition than PH lesions alone. K E Y W O R D S cribra orbitalia, hidden heterogeneity, porotic hyperostosis, stress, survival analysis

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Indicators of stress and their association with frailty in the precontact Southwestern United States

O’Donnell

2019

American J Phys Anthropol

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“…People possessing increased risk of death during the Medieval epidemic were those with shorter adult stature and histories of morbidity earlier in life. Watts (2013) found that VNC stunting, femoral length, cribra orbitalia, and craniofacial asymmetry were varyingly associated with long-term effects on health throughout the lifespan and younger age-atdeath. These studies hopefully represent the vanguard of an increasing emphasis on the possible implications of the DOHaD hypothesis in skeletal tissue.…”

Section: The Allure (Im)possibilities and Glimpses Of Epigenetic Mementioning

confidence: 95%

Frontiers in the bioarchaeology of stress and disease: Cross‐disciplinary perspectives from pathophysiology, human biology, and epidemiology

Klaus

2014

American J Phys Anthropol

134

103

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Over the last four decades, bioarchaeology has experienced significant technical growth and theoretical maturation. Early 21st century bioarchaeology may also be enhanced from a renewed engagement with the concept of biological stress. New insights on biological stress and disease can be gained from cross-disciplinary perspectives regarding human skeletal variation and disease. First, pathophysiologic and molecular signaling mechanisms can provide more precise understandings regarding formation of pathological phenotypes in bone. Using periosteal new bone formation as an example, various mechanisms and pathways are explored in which new bone can be formed under conditions of biological stress, particularly in bone microenvironments that involve inflammatory changes. Second, insights from human biology are examined regarding some epigenetic factors and disease etiology. While epigenetic effects on stress and disease outcomes appear profoundly influential, they are mostly invisible in skeletal tissue. However, some indirect and downstream effects, such as the developmental origins of adult health outcomes, may be partially observable in bioarchaeological data. Emerging perspectives from the human microbiome are also considered. Microbiomics involves a remarkable potential to understand ancient biology, disease, and stress. Third, tools from epidemiology are examined that may aid bioarchaeologists to better cope with some of the inherent limitations of skeletal samples to better measure and quantify the expressions of skeletal stress markers. Such cross-disciplinary synergisms hopefully will promote more complete understandings of health and stress in bioarchaeological science.

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“…A number of studies within palaeopathology have provided support for this hypothesis from archaeological contexts, noting correlations between indicators of health stress such as enamel hypoplasia and growth stunting, and reduced adult longevity (e.g. Armelagos et al 2009;Watts 2011Watts , 2013. Ultimately, in terms of the bioarchaeology of childhood in the past, the DOHaD hypothesis should at the very least, result in a deepening appreciation of the significance of the analysis of the remains of infants and children for understanding population well-being.…”

Section: The Social Bioarchaeology Of the Childmentioning

confidence: 99%

Child Bioarchaeology: Perspectives on the Past 10 Years

Mays

Gowland

Halcrow

et al. 2017

Childhood in the Past

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The full-text may be used and/or reproduced, and given to third parties in any format or medium, without prior permission or charge, for personal research or study, educational, or not-for-prot purposes provided that:• a full bibliographic reference is made to the original source • a link is made to the metadata record in DRO • the full-text is not changed in any way The full-text must not be sold in any format or medium without the formal permission of the copyright holders.Please consult the full DRO policy for further details. This article aims to provide an overview of some of the more important developments in the bioarchaeology of childhood over the past decade. Analysis of publication trends in the major osteoarchaeology and physical anthropology journals demonstrated a rise in research papers dealing with skeletal remains of children, with dietary and palaeopathological studies especially predominant. Innovations in these areas are discussed in more detail, together with some important developments in theoretical frameworks for using skeletal evidence to situate children in past societies. Among these latter is the life course approach, in which childhood is considered within the context of the trajectory of the entire life course. The integration of studies of child skeletal remains with those of adults helps to provide a more complete picture of communities in the past.

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Childhood development and adult longevity in an archaeological population from Barton-upon-Humber, Lincolnshire, England

Cited by 65 publications

References 70 publications

Indicators of stress and their association with frailty in the precontact Southwestern United States

Indicators of stress and their association with frailty in the precontact Southwestern United States

Frontiers in the bioarchaeology of stress and disease: Cross‐disciplinary perspectives from pathophysiology, human biology, and epidemiology

Child Bioarchaeology: Perspectives on the Past 10 Years

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