Childhood Epilepsy With Occipital Paroxysms: Clinical Variants in134 Patients

Kivity, Shaye; Ephraim, T; Weitz, Raphael; Tamir, Abraham

doi:10.1111/j.1499-1654.2000.001522.x

Cited by 60 publications

(13 citation statements)

References 25 publications

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“…Moreover, occipital paroxysms are a nonspecific electroencephalographic manifestation observed in many epileptic and nonepileptic disorders. They are morphologically similar to the abnormalities observed in BECTS, the main difference being that the waves occur in the occipital rather than in the centrotemporal regions [7] . As in BEI, subclinical cortical hyperexcitability in healthy children (without associated clinical recognizable seizures) may migrate to different brain areas as an expression of maturation, though no studies that have yet provided conclusive data exist, suggesting that this migrating hyperexcitability is age-related.…”

Section: Introductionsupporting

confidence: 72%

“EEG abnormalities” may represent a confounding factor in celiac disease: A 4-year follow-up family report

Parisi

Principessa

Ferretti

et al. 2014

Epilepsy & Behavior Case Reports

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ObjectiveThe occurrence of celiac disease (CD), electroencephalographic (EEG) abnormalities (with “subtle” seizures or even without any clinical seizures), and neurological disorders has been reported since the 1980s, though there has been no definitive consensus about the possible causal relationship. This topic is further complicated by the occurrence in infancy of ‘clinical–EEG pictures’ called ‘benign epilepsy of infancy’.Methods and resultsHere, we report a 4-year follow-up on two siblings with newly diagnosed biopsy-proven celiac disease showing EEG abnormalities not responsive to a gluten-free diet.ConclusionsThis family report indicates that in patients with neurologically asymptomatic CD and EEG abnormalities, it is advisable to make a differential diagnosis between EEG abnormalities associated with CD and an incidental association with cortical hyperexcitability, with “subtle” seizures or even without any clinical seizures.Practice implicationsA long follow-up may sometimes be required, as it was in the family described here, to clarify the etiopathogenetic and therapeutic relationships between clinical and EEG features in CD.

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Section: Introductionsupporting

confidence: 72%

“EEG abnormalities” may represent a confounding factor in celiac disease: A 4-year follow-up family report

Parisi

Principessa

Ferretti

et al. 2014

Epilepsy & Behavior Case Reports

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“…Most clinicians treat seizures with CBZ or VPA. [ 12 13 14 ] García and Rubio[ 15 ] reported that LEV used in three children with PS type. They found efficacy on seizure control in PS.…”

Section: Discussionmentioning

confidence: 99%

First-drug treatment failures in 42 Turkish children with idiopathic childhood occipital epilepsies

İncecik

Hergüner

Altunbaşak

2015

Journal of Neurosciences in Rural Practice

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Background:The early and late benign occipital epilepsies of childhood (BOEC) are described as two discrete electro-clinical syndromes, eponymously known as Panayiotopoulos and Gastaut syndromes. The purpose of this study was to identify predictors of failure to respond to the initial antiepileptic drug (AED).Materials and Methods:A total of 42 children with BOEC were enrolled. Predictive factors were analyzed by survival methods.Results:Among the 42, 25 patients (59.5%) were boys and 17 (40.5%) were girls and the mean age at the seizure onset was 7.46 ± 2.65 years (4–14 years). Of the 42 patients, 34 (81.0%) were treated relatively successfully with the first AED treatment, and 8 (19.0%) were not responded initial AED treatment. There was no correlation between response to initial AED treatment and sex, consanguinity, epilepsy history of family, age of seizure onset, frequency of seizures, history of status epilepticus, duration of starting first treatment, findings on electroencephalogram. However, history of febrile seizure and type of BOEC were significantly associated with failure risk.Conclusions:Factors predicting failure to respond to the AED were history of febrile seizure and type of BOEC in children with BOEC.

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“…While vomiting has been cited to occur as the initial event in 60-80% (Lada et al 2003Koutroumanidis, 2002, Panayiotopoulos, 2001, Oguni et al 1999, others have reported a frequency of only 44% (Kivity et al 2000). Vomiting is accompanied or followed by tonic eye, and less commonly head, deviation in 70-98% (Oguni et al 1999, Caraballo et al 2000.…”

Section: Clinical Manifestations Of Panayiotopoulos-type Bceopmentioning

confidence: 99%

“…Fixation-off sensitivity (FOS), the occurrence of interictal discharges as the result of elimination of central vision and fixation, is a feature of both types of BCEOP (Panayiotopoulos, 1989, Panayiotopoulos, 1998a. Fixation-off sensitivity occurs less commonly in other conditions as compared to BCEOP (Kivity et al 2000. Panayiotopoulos, 1998a.…”

Section: Eeg Findings In Bceopmentioning

confidence: 99%

“…In 33% of cases, seizures last 2 to 10 minutes (Kivity et al 2000, Kivity andLerman 1992). Seizure frequency is highly variable, ranging from an isolated seizure in 18-53% to more than several seizures per month in 5-26% (Koutroumanidis 2002, Caraballo et al 2000, Oguni et al 1999, Ferrie et al 1997.…”

Section: Clinical Manifestations Of Panayiotopoulos-type Bceopmentioning

confidence: 99%

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Benign pediatric localization‐related epilepsies Part II. Syndromes in childhood

Chahine,

Mikati

2006

Epileptic Disorders

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By definition, benign epilepsy syndromes occur in patients with no significant prenatal, perinatal, or postnatal complications, normal psychomotor development and negative laboratory and neuroimaging work‐up, respond well to therapy, and remit without sequeale. The benign localization‐related epilepsy syndromes of childhood include benign childhood epilepsy with centrotemporal spikes, Panayiotopoulos syndrome and Gastaut‐type idiopathic childhood epilepsy with occipital paroxysms. Some patients initially presumed to have these or, for that matter, other benign syndromes in other age groups, follow a less typical course and continue to experience seizures or to exhibit neuropsychological deficits. Thus the diagnosis of a “possible” or “probable” benign epilepsy syndrome may need to be applied to patients initially suspected of having such syndromes until follow‐up shows that they clearly follow a benign course. In Part I (Chahine and Mikati 2006) of our two‐part review article, we discussed benign localization‐related syndromes encountered in infancy. In this second part, we review the epidemiology, clinical manifestations, neuropsychological features, EEG findings, work‐up and diagnostic criteria, differential diagnosis, genetics, management and prognosis of the three childhood‐onset syndromes. In addition, we discuss their occasional overlap with or progression into other syndromes.

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Childhood Epilepsy With Occipital Paroxysms: Clinical Variants in134 Patients

Abstract: The most common type of CEOP, the Panayiotopoulos type, is characterized by a cluster of signs and symptoms sufficiently delineated to justify their separate classification from Gastaut-type CEOP, despite the absence of ictal vomiting in more than 50% of the patients.

Cited by 60 publications

References 25 publications

“EEG abnormalities” may represent a confounding factor in celiac disease: A 4-year follow-up family report

“EEG abnormalities” may represent a confounding factor in celiac disease: A 4-year follow-up family report

First-drug treatment failures in 42 Turkish children with idiopathic childhood occipital epilepsies

Benign pediatric localization‐related epilepsies Part II. Syndromes in childhood

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