Childhood erythrodermic lichen planus pemphigoides after nonavalent human papillomavirus vaccination

Pizzatti, Laura; Ferreli, Caterina; Conti, Brunella; Atzori, Laura; Pinna, Giampietro; Pilloni, Luca; Rongioletti, Franco

doi:10.1016/j.jdcr.2020.03.008

Cited by 3 publications

(6 citation statements)

References 18 publications

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“…Although the vaccines are generally safe, numerous reports highlighted the occurrence of autoimmune effects after single or combined multivaccine procedures. Only one paediatric erythrodermic LP pemphigoides following nonavalent human papillomavirus vaccination was recently described 10 . In our patient, the vaccination against hepatitis A could be considered as a triggering factor for developing this autoimmune skin disorder.…”

Section: Discussionmentioning

confidence: 66%

“…Only one paediatric erythrodermic LP pemphigoides following nonavalent human papillomavirus vaccination was recently described. 10 In our patient, the vaccination against hepatitis A could be considered as a triggering factor for developing this autoimmune skin disorder. Molecular mimicry and bystander activation are possible mechanisms by which vaccines can cause autoimmune reactions.…”

Section: Discussionmentioning

confidence: 74%

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Severe childhood lichen planus pemphigoides after hepatitis A vaccination

Lahouel

Aounallah

Mokni

et al. 2022

Skin Health and Disease

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Background Lichen planus (LP) pemphigoides (LPP) is a very rare autoimmune bullous disorder, that is, exceptional in children. Case Report We report a case of LP pemphigoides with severe cutaneous and mucosal involvement in an 8‐year‐old girl who consulted for multiple vesicular and bullous lesions associated with shiny erythematous‐purple plaques. The eruption occurred 2 months after vaccination against hepatitis A virus. The diagnosis of LP pemphigoides was confirmed by histopathology and immunofluorescence examination. The patient received oral corticosteroid therapy with rapid improvement. Conclusion To our knowledge, this is the first report of LPP following hepatitis A vaccination, among adults and children.

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Section: Discussionmentioning

confidence: 66%

Section: Discussionmentioning

confidence: 74%

Severe childhood lichen planus pemphigoides after hepatitis A vaccination

Lahouel

Aounallah

Mokni

et al. 2022

Skin Health and Disease

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“…Prior studies reported adverse events of an association between HPV vaccination and mucocutaneous diseases, such as erythema multiforme, erythema nodosum, dermographism, urticaria, and linear IgA bullous dermatosis. A lichenoid eruption in the skin after the 9v-HPV vaccination has also been reported (Laschinger et al, 2015;Pizzatti et al, 2020). OLP with HPV vaccination has not been reported up to now.…”

Section: Human Papillomavirus Vaccination Induced Oral Lichen Planusmentioning

confidence: 84%

Human papillomavirus vaccination induced oral lichen planus

2022

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“…In addition, LPP has been reported to be related with multiple factors (1), including drugs (angiotensin converting enzyme inhibitor, PD-1 inhibitor, antidepressants, etc. ), infections (varicella and hepatitis B), UV therapy (narrow band UVB and psoralen UVA therapy), vaccinations (7,8), tumors, and body tattooing (10). For the two cases triggered by vaccines, one was induced by hepatitis A vaccination (9) and the other by non-avalent human papillomavirus vaccination (8).…”

Section: Discussionmentioning

confidence: 99%

“…It was declared that medication, infections, vaccines, and tumors could be the associated triggers of LPP (1). Only two cases have been illustrated to be vaccine-related: one was triggered by hepatitis A vaccination (7) and the other by non-avalent human papillomavirus vaccination (8). No such cases following COVID-19 vaccination have been recorded till now.…”

Section: Introductionmentioning

confidence: 99%

Case report: Successful treatment of non-bullous lichen planus pemphigoides with dupilumab

Xie

Wang

et al. 2022

Front. Med.

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Lichen planus pemphigoides (LPP) is a rare autoimmune bullous disease, characterized by the coexistence of lichen planus and subepidermal bullae. However, the minority of LPP patients present with papules rather than vesicles or blisters, which is defined as non-bullous LPP. The diagnosis of LPP relies on manifestations, histopathology, serological assay, and direct immunofluorescence of linear disposition of IgG and/or C3 at the basement membrane zone. Up to now, no standard therapeutic strategies have been proposed for the treatment of LPP. Herein, we describe an uncommon non-bullous LPP patient with widespread papules and erythema, probably induced by vaccination. During hospitalization, he had a poor response to the conventional treatment of topical and systemic corticosteroids, and his condition was finally alleviated by the addition of dupilumab. For LPP patients with a traditional medication failure, or who were not suitable for a higher dose of corticosteroids, a combination with dupilumab could be an alternative option.

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Childhood erythrodermic lichen planus pemphigoides after nonavalent human papillomavirus vaccination

Cited by 3 publications

References 18 publications

Severe childhood lichen planus pemphigoides after hepatitis A vaccination

Severe childhood lichen planus pemphigoides after hepatitis A vaccination

Human papillomavirus vaccination induced oral lichen planus

Case report: Successful treatment of non-bullous lichen planus pemphigoides with dupilumab

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