Childhood intrathoracic Hodgkin lymphoma with hypertrophic pulmonary osteoarthropathy: a case report and review of the literature

Ütine, Eda; Yalçın, Bilgehan; Karnak, İbrahìm; Kale, Gülsev; Yalçın, Ebru; Ki̇per, Nural; Akyüz, Canan; Büyükpamukçu, Münevver

doi:10.1007/s00431-007-0522-z

Cited by 12 publications

(9 citation statements)

References 21 publications

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“…HOA is thought to be a paraneoplastic process and vascular endothelial growth factor, platelet derived growth factor, and prostaglandin E2 have all been hypothesized to play a role in the pathogenesis 16. Approximately 92% of adult HOA cases occur in the setting of malignancy, compared to 12% of pediatric HOA 17, 18. In pediatric cancer, HOA has been reported in nasopharyngeal carcinoma, Hodgkin's Lymphoma, osteosarcoma, thymic carcinoma, rhabdomyosarcoma, periosteal sarcoma, and pleural mesothelioma 17.…”

Section: Discussionmentioning

confidence: 99%

“…Approximately 92% of adult HOA cases occur in the setting of malignancy, compared to 12% of pediatric HOA 17, 18. In pediatric cancer, HOA has been reported in nasopharyngeal carcinoma, Hodgkin's Lymphoma, osteosarcoma, thymic carcinoma, rhabdomyosarcoma, periosteal sarcoma, and pleural mesothelioma 17. This is the first reported case of HOA with IF.…”

Section: Discussionmentioning

confidence: 99%

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Cardiac metastasis and hypertrophic osteoarthropathy in recurrent infantile fibrosarcoma

Shah

Price

Loeb

2011

Pediatric Blood & Cancer

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Cardiac metastasis and hypertrophic osteoarthropathy are both quite rare. We describe a patient presenting with hypertrophic osteoarthropathy as the first symptom of recurrent infantile fibrosarcoma (IF). During surgical resection of lung metastasis, the patient suffered sudden cardiac arrest. Autopsy demonstrated a metastatic lesion in the intraventricular septum of the heart, which is previously undescribed in the literature. This case demonstrates that IF can be aggressive despite its more typical benign course.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Cardiac metastasis and hypertrophic osteoarthropathy in recurrent infantile fibrosarcoma

Shah

Price

Loeb

2011

Pediatric Blood & Cancer

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“…[5–7] It is also known that other tumors can cause secondary HOA. [8] However, it occurs rarely in other malignancies. [4,8] There are also no reports providing systemic data about HOA in nonpulmonary or nonpleural malignant tumors.…”

Section: Introductionmentioning

confidence: 99%

Secondary hypertrophic osteoarthropathy caused by non-pleural or pulmonary tumors

et al. 2017

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Hypertrophic osteoarthropathy (HOA) is a rare paraneoplastic syndrome characterized by digital clubbing, periosteal reaction, polyarthralgia, arthritis, and synovitis. Herein, we report a case series of patients with secondary HOA caused by non-pleural or pulmonary tumors.The radiologic databases of 2 tertiary university hospitals were retrospectively screened for secondary HOA patients. In addition, a systemic review of the published case reports. Only HOA cases with non-pleural or pulmonary malignancies were involved into the study. HOA in primary pleural or pulmonary malignant or benign disorders, as well in inflammatory diseases were excluded. In all cases, plain radiography was performed and clinical signs were documented.In our databases, 6 patients with secondary HOA were identified. In addition, the systemic review yielded 24 eligible patients. The most prevalent primary tumors were nasopharyngeal carcinoma and esophageal cancer in 6 patients (20%), respectively. In 17 patients, (56.7%) HOA was associated with lung metastases, and in 10 patients (33.3%), no lung metastases were detected. In 14 patients (46.7%), HOA was symptomatically before a tumor diagnosis was made. Plain radiography displayed typically features with periostal enlargement in every case.This study is the first report about secondary HOA caused by non-pleural or pulmonary tumors. Various primary tumors were identified, including several rare tumors such as sarcomas. HOA is a rare disorder with typically radiologically findings, which is not only associated with lung cancer or pleural mesothelioma and can even occur in tumor patients without lung metastasis.

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“…HOA is found mainly in dogs (Headley et al, 2005;Cetinkaya et al, 2011;Lawler et al, 2015) and humans (Golder and Wolf, 2001;Utine et al, 2008), but has been observed occasionally in various other species (Lenehan and Fetter, 1985;Golder and Wolf, 2001;Mair and Tucker, 2004;Ferguson et al, 2008;Guyot et al, 2011). Although HOA was described in 1868 by Friedenreich (as cited in Kuhn et al, 2007), the exact aetiology remains unknown.…”

Section: Introductionmentioning

confidence: 99%

Characterization of hypertrophic osteoarthropathy in an identified skeleton from Évora, Portugal, using combined and comparative morphology and microscopy

Anselmo

Silva

Fernandes

2016

International Journal of Paleopathology

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a b s t r a c tHypertrophic osteoarthropathy (HOA) is a bone pathology that can be associated with a number of focal or systemic diseases, particularly those affecting the respiratory system. HOA is characterized by proliferative periostosis of the long bones, especially in their distal and periarticular regions. This report presents a probable case of HOA in the skeleton of an elderly Portuguese male from Évora, Portugal, who died in 1970.The skeleton was evaluated by morphological, radiological, and histological methods. We found bilateral periosteal proliferation of the tubular bones, remodeling of the phalanges of the feet, and new bone formation on rib visceral surfaces. Bone alterations are more severe on the left tibia and fibula, where lesions display a 'tree bark' appearance, leading to severe thickening of the diaphysis.Microscopically, we observed deposition of porous woven bone. Our evaluation also considers a differential diagnosis of the lesions, which includes melorheostosis, hypervitaminosis A, fluorosis, thyroid acropachy, tuberculosis, and treponematosis.

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Childhood intrathoracic Hodgkin lymphoma with hypertrophic pulmonary osteoarthropathy: a case report and review of the literature

Cited by 12 publications

References 21 publications

Cardiac metastasis and hypertrophic osteoarthropathy in recurrent infantile fibrosarcoma

Cardiac metastasis and hypertrophic osteoarthropathy in recurrent infantile fibrosarcoma

Secondary hypertrophic osteoarthropathy caused by non-pleural or pulmonary tumors

Characterization of hypertrophic osteoarthropathy in an identified skeleton from Évora, Portugal, using combined and comparative morphology and microscopy

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