Childhood Intussusception after Introduction of Indigenous Rotavirus Vaccine: Hospital-Based Surveillance Study from Odisha, India

Abstract

Objective To know the rotavirus burden associated with acute gastroenteritis along with circulating genotypes among under-five children and to find out possible associations with different demographic and clinical predictors in a tertiary care teaching hospital in Bhubaneswar, Odisha. Methods A prospective acute gastroenteritis surveillance conducted from February 2016 to June 2019 at a tertiary care pediatric hospital in Bhubaneswar has enrolled 850 children under five years of age. The stool samples were tested for VP6 antigen of rotavirus by enzyme immunoassay (EIA) and hemi-nested multiplex PCR to find out VP7 (G type) and VP4 (P type) genes. The data was presented using mean ± SD, median (IQR) along with frequencies and percentages. Results Rotavirus positivity was found in 246 children (28.9%) with male : female ratio of 3:1. An increasing trend of rotaviral diarrheal cases was seen during the winter months. History of vomiting for 2 d, age group of 12-23 mo, and fever were significantly associated with rotavirus diarrhea having odd ratios of 1.80 (95% CI , 1.48, and 1.69, respectively. Among the genotypes, G3 and P8 were found to be most common in the present study. Conclusion With the introduction of Rotavac in the state the overall rotaviral distribution has significantly changed. Children of 6-23 mo were the most affected age group in the study indicating the necessity of this vaccine in the early months of life. Response to Reviewers:We have modified the manuscript as desired. Methodology part was rewritten to avoid

Determinants of COVID-19 vaccine-induced myocarditis

“…64 In 1998, a vaccine designed to prevent rotavirus gastroenteritis was associated with childhood intussusception after being vaccinated. 65 , 66 Finally, in the early 2000s, a hepatitis B vaccine product was linked to multiple sclerosis. 67 …”

Information for Action: The Power of Surveillance

“…But in addition to the data combined for robustness of analysis, there are many descriptions of findings and analysis that are important at the local and national level, on disease burden, patterns, and safety issues. The reports by location, including papers from Tirupati, Rohtak, Mewat, Chandigarh, Tanda, Bhubaneswar, Sonepat, Indore, Bijnor, Kakinada, and Varanasi [6][7][8][9][10][11][12][13][14][15][16][17][18][19], by clinical features from Mewat in Haryana and Cuttack in Odisha, the molecular characterization from sites in Odisha, Haryana and Rajasthan [11][12][13][20][21][22], the safety data from the sites in Odisha, Haryana, Tamil Nadu, and Rajasthan [23][24][25][26] and the nutritional status and its association with diarrheal illness from Mewat [27] round out the data to present a comprehensive picture of rotavirus disease and burden in India.…”