Childhood leukemia in california-born twins

Jackson, Edwin W.; Norris, Frank D.; Klauber, Melville R.

doi:10.1002/1097-0142(196904)23:4<913::aid-cncr2820230429>3.0.co;2-p

Cited by 34 publications

(11 citation statements)

References 7 publications

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“…The ORLS deficit of twin childhood cancer agrees with the findings of other cohort studies (Hewitt et al, 1966;Jackson et al, 1969;Norris and Jackson, 1970;Windham et al, 1985;Inskip et al, 1991;Rodvall et al, 1992). Our study is most comparable to that of Windham et al in terms of size and the period of twin birth (Windham et al, 1985).…”

Section: Discussionsupporting

confidence: 92%

Childhood cancer incidence in a cohort of twin babies

Murphy¹,

Whiteman²,

Hey³

et al. 2001

Br J Cancer

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We studied childhood cancer incidence in a population-based twin cohort using record linkage to the National Registry of Childhood Tumours. After correcting for mortality, an incidence deficit was observed (Standardized Incidence Ratio (SIR) 79; 95% Confidence Interval (CI) 39–120). Pooled analysis with data from published cohort studies indicates a similar significant incidence reduction (SIR 81, 95% CI 67–96). Further studies are warranted. © 2001 Cancer Research Campaign http://www.bjcancer.com

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Section: Discussionsupporting

confidence: 92%

Childhood cancer incidence in a cohort of twin babies

Murphy¹,

Whiteman²,

Hey³

et al. 2001

Br J Cancer

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“…While studying fingerprint characteristics in sibships with acute lymphocytic leukemia [38], we noted a tendency of the children with leukemia to have greater births weights than their sibs. This observation supplements earlier studies of childhood leukemia which indicated a relation to birth characteristics, such as maternal age, birth order, and birth weight [13,19,24,30].…”

Section: Introductionsupporting

confidence: 90%

“…The observation of greater birth weight in children with acute lymphocytic leukemia finds support in earlier studies of twins discordant for cancer [24] and leukemia [13]. These studies revealed that the twin affected with cancer tends to be larger than the twin free of neoplasia.…”

Section: Discussionmentioning

confidence: 99%

Increased Birth Weight in Leukemia

Wertelecki

Mantel

1973

Pediatr Res

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ExtractThis paper reports the study of birth order and birth weight ranks of 72 children suffering from acute lymphocytic leukemia. ChiHren who developed lymphocytic leukemia had greater birth weights than expected in all comparisons (P < 0.5-0.005). SpeculationGenetic, immunologic, and nutritional factors reflect upon birth weight as well as carcinogenesis. The elucidation of immune, nutritional, or genetic bases for the increased birth weight in leukemia would contribute to the understanding of risk factors for this disorder. Children who develop leukemia at an early age are more likely to reveal the association of leukemia to increased birth weight.

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“…Two previous studies of twinship and childhood cancer have attempted to control for birth weight. One study assessed whether cancer occurred more often in the heavier twin, which was the case for leukemia but not all other cancer types combined (5, 9). Another found that there was a reduced incidence of childhood cancer overall in twins weighing below 3000g at birth and an excess in twins weighing 3000g or more (7).…”

Section: Discussionmentioning

confidence: 99%

Childhood Cancer among Twins and Higher Order Multiples

Puumala¹,

Carozza

Chow

et al. 2009

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Although several studies have found no change or a decreased risk of childhood cancer in twins, few have controlled for potential confounders such as birth weight. We examined the association of birth plurality and childhood cancer in pooled data from five U.S. states (California, Minnesota, New York, Texas, and Washington) using linked birth-cancer registry data. The data, excluding children with Down syndrome or who died before 28 days of life, included 17,672 cases diagnosed from 1980 to 2004 at ages 28 days to 14 years and 57,966 controls with all cases and controls born from 1970 to 2004. Analyses were restricted to children weighing V4,000 g at birth. Odds ratios (OR) and 95% confidence intervals (95% CI) were estimated using unconditional logistic regression adjusting for sex, gestational age, birth weight, birth order, maternal age, maternal race, state of birth, and birth year. Children who were multiples had no difference in risk of cancer overall (OR, 0.93; 95% CI, 0.82-1.07), but a borderline reduced risk of Wilms' tumor (OR, 0.65; 95% CI, 0.39-1.09). For children diagnosed <2 y of age there was a reduced risk of Wilms' tumor (OR, 0.27; 95% CI, 0.09-0.86) and neuroblastoma (OR, 0.46; 95% CI,) and an increased risk of fibrosarcoma (OR, 5.81; 95% CI,). Higher-order multiple birth (triplets or higher) was not associated with childhood cancer. Our analysis suggests that mechanisms other than birth weight and gestational age may influence the lower risk of Wilms' tumor and neuroblastoma in multiple births. (Cancer Epidemiol Biomarkers Prev 2009;18(1):162-8)

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Childhood leukemia in california-born twins

Cited by 34 publications

References 7 publications

Childhood cancer incidence in a cohort of twin babies

Childhood cancer incidence in a cohort of twin babies

Increased Birth Weight in Leukemia

Childhood Cancer among Twins and Higher Order Multiples

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