Childhood Lung Function Predicts Adult Chronic Obstructive Pulmonary Disease and Asthma–Chronic Obstructive Pulmonary Disease Overlap Syndrome

Bui, Dinh; Burgess, John A.; Lowe, Adrian J.; Perret, Jennifer L; Lodge, Caroline; Bui, Minh; Morrison, Stephen; Thompson, Bruce; Thomas, Paul S.; Giles, Graham G.; Garcia‐Aymerich, Judith; Jarvis, Déborah; Abramson, Michael J.; Walters, E. Haydn; Matheson, Melanie C.

doi:10.1164/rccm.201606-1272oc

Cited by 123 publications

(99 citation statements)

References 33 publications

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“…Logistic regression models were also fitted using continuous telomere length as the independent variable to assess the odds of having poor lung function. The lowest quartile for each spirometric index was compared to the highest quartile (ie, the reference group), given that being in the lowest quartile has been shown to infer future risk of lung disease and increased respiratory morbidity …”

Section: Methodsmentioning

confidence: 99%

Telomere length and lung function in a population‐based cohort of children and mid‐life adults

Nguyen

Saffery

Burgner

et al. 2019

Pediatric Pulmonology

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Objective Telomere length is associated with poorer lung health in older adults, possibly from cumulative risk factor exposure, but data are lacking in pediatric and population‐based cohorts. We examined associations of telomere length with lung function in children and mid‐life adults. Methods Data were drawn from a population‐based cross‐sectional study of 11 to 12 year‐olds and mid‐life adults. Lung function was assessed by spirometric FEV1, FVC, FEV 1/FVC ratio, and MMEF 25‐75. Telomere length was measured by quantitative polymerase chain reaction from blood and expressed as the amount of telomeric genomic DNA to the beta‐globin gene (T/S ratio). Associations of telomere length with spirometric parameters were tested by linear and logistic regression models, adjusting for potential confounders of sex, age, body mass index, socioeconomic position, physical activity, inflammation, asthma, pubertal status, and smoking. Results Mean T/S ratio was 1.09 (n = 1206; SD 0.55) in children and 0.81 (n = 1343; SD 0.38) in adults. In adults, for every additional unit in T/S ratio, FEV 1/FVC and MMEF 25‐75 z‐scores were higher (β 0.21 [95% confidence interval, CI; 0.06‐0.36] and 0.23 [95% CI; 0.08‐0.38], respectively), and the likelihood of being in the lowest quartile for FEV 1/FVC and MMEF 25‐75 z‐scores was lower (odds ratios 0.59 [95% CI, 0.39‐0.89] and 0.64 [95% CI, 0.41‐0.99], respectively). No evidence of association was seen for adult FEV 1 or FVC, or any childhood spirometric index after adjustments. Conclusion Shorter telomere length showed moderate associations with poorer airflow parameters, but not vital capacity (lung volume) in mid‐life adults. However, there was no convincing evidence of associations in children.

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Section: Methodsmentioning

confidence: 99%

Telomere length and lung function in a population‐based cohort of children and mid‐life adults

Nguyen

Saffery

Burgner

et al. 2019

Pediatric Pulmonology

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“…Tasmanian children who were in the lowest quartile of FEV 1 /FVC at age 7 years had a six- to 16-fold increase in their odds for COPD in the absence or presence of concomitant asthma by age 45 9 . In the population-based Tucson Children’s Respiratory Study, participants in the lowest quartile of airway function in early infancy had significantly lower values for FEV 1 and FEV 1 /FVC up to age 22 as compared with participants in the upper three quartiles 95 , and a distinct group of individuals with persistently low lung function between the ages of 11 and 32 years (a large proportion of whom did not have asthma) could be identified by using latent class analysis 10 .…”

Section: Lung Function Trajectories From Childhood Into Adult Lifementioning

confidence: 95%

“…Evidence is now emerging that several chronic adult diseases—including chronic obstructive pulmonary disease (COPD), which is estimated by the World Health Organization (WHO) to become the third leading cause of death worldwide by 2030 3 —may have part of their origins early in life 4– 9 . These observations fit well with the Developmental Origins of Health and Disease (DOHaD) concept that describes how early life exposures may have a long-term impact on diseases in adulthood 5, 6, 10– 12 .…”

Section: Introductionmentioning

confidence: 99%

Recent advances in understanding lung function development

Melén

Guerra

2017

F1000Res

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Recent years have witnessed critical contributions to our understanding of the determinants and long-term implications of lung function development. In this article, we review studies that have contributed to advances in understanding lung function development and its critical importance for lung health into adult life. In particular, we have focused on early life determinants that include genetic factors, perinatal events, environmental exposures, lifestyle, infancy lower respiratory tract infections, and persistent asthma phenotypes. Longitudinal studies have conclusively demonstrated that lung function deficits that are established by school age may track into adult life and increase the risk of adult lung obstructive diseases, such as chronic obstructive pulmonary disease. Furthermore, these contributions have provided initial evidence in support of a direct influence by early life events on an accelerated decline of lung function and an increased susceptibility to its environmental determinants well into adult life. As such, we argue that future health-care programs based on precision medicine approaches that integrate deep phenotyping with tailored medication and advice to patients should also foster optimal lung function growth to be fully effective.

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“…7 If the patient has an overlap syndrome with an asthmatic component, the term ACOS (asthma and chronic obstructive overlap syndrome) is used. 8 Radiological characteristics of COPD are thickened bronchial walls, whereas emphysema is characterized by rarefication of lung parenchyma. 9,10 Air trapping represents another hallmark in the COPD spectrum.…”

mentioning

confidence: 99%

Increased Expiratory Computed Tomography Density Reveals Possible Abnormalities in Radiologically Preserved Lung Parenchyma in Idiopathic Pulmonary Fibrosis

Petroulia¹,

Funke²,

Zumstein³

et al. 2018

Invest Radiol

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Objectives: Idiopathic pulmonary fibrosis (IPF) is a progressive lethal chronic lung disease with unclear pathogenesis. Radiological hallmark is the pattern of usual interstitial pneumonia accentuated in peripheral and basal areas with otherwise preserved lung structure. One hypothesis is that alveolar collapse and consequent induration lead to fibrotic transformation of lung tissue. The aim of the study was to investigate normal-appearing tissue during expiration for signs of collapsibility and differences from other diseases or controls. Materials and Methods: We retrospectively assessed a total of 43 patients (15 IPFs, 13 chronic obstructive pulmonary diseases, and 15 controls) with nonenhanced computed tomography (CT) in inspiration and expiration, performed for routine clinical workup. Densitometry of visually unaffected lung tissue was conducted in all lung lobes with a region of interest of 15-mm in diameter on soft tissue kernel reconstruction (slice thickness, 1 mm) during inspiration and expiration. Results: One-factor analysis of variance analysis yielded significant difference in attenuation changes between inspiration and expiration of unaffected lung parenchyma among all subject groups in all lung lobes. For IPF patients, the highest differences in densities were observed in the lower lobes, which is the predominantly affected site of usual interstitial pneumonia. In the chronic obstructive pulmonary disease group, the density remained rather equal in the entire lung. Conclusions: High CT attenuation changes between inspiration and expiration in IPF patients might suggest altered lung parenchyma in normal-appearing tissue on CT. Density changes during the respiratory cycle might be explained by alveolar collapse of radiologically unaffected lung tissue possibly preceding fibrosis. These results support the concept of alveolar collapse preceding lung fibrosis in IPF.

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Childhood Lung Function Predicts Adult Chronic Obstructive Pulmonary Disease and Asthma–Chronic Obstructive Pulmonary Disease Overlap Syndrome

Cited by 123 publications

References 33 publications

Telomere length and lung function in a population‐based cohort of children and mid‐life adults

Telomere length and lung function in a population‐based cohort of children and mid‐life adults

Recent advances in understanding lung function development

Increased Expiratory Computed Tomography Density Reveals Possible Abnormalities in Radiologically Preserved Lung Parenchyma in Idiopathic Pulmonary Fibrosis

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