Childhood maltreatment and social functioning in psychotic disorders: a systematic review protocol

Abstract

Background: Childhood maltreatment (CM) is thought to play a key role in the etiology and course of psychotic disorders (PD). In addition, CM is related to neurobiological and clinical characteristics that can lead to poor social functioning. However, the extent to which CM and social functioning are directly associated in individuals with PD, is unclear. Therefore, we aim to systematically review the literature to provide an estimate on the strength of the association between CM and different domains of social functioning in PD and to summarize potential moderators and mediators of this association. Methods and analysis: To identify relevant studies, we will systematically search the following databases: Pubmed (Medline), PsycInfo, Embase, Web of Science (Core Collection), and Pilots (trauma), manually search reference lists and contact experts in the field. Studies will be included if they investigate and report on the association between CM (exposure) and social functioning (outcome) in adults with PD. Two independent reviewers will screen titles, abstracts and full texts according to eligibility criteria, perform data extraction and assess study quality according to a modified version of the Newcastle-Ottawa Scale. Analysis: Effect estimates will be pooled in a meta-analysis. Heterogeneity and publication bias will be assessed and the effects of potential moderators (genetic factors, type of diagnosis, duration of illness, type of CM and age at the time of CM exposure) will be analyzed using meta-regressions. Candidate moderators and mediators (neurocognition, cognitive schemas, comorbidities, stress sensitivity, attachment) will be also examined qualitatively. Ethics and dissemination: Because this review will make use of already published data, ethical approval will not be sought. This work has the potential to inform upcoming investigations on the association between the exposure to CM in PD and social functioning. PROSPERO registration number CRD42020175244.

Correlation between emotion dysregulation and mood symptoms of bipolar disorder: A systematic review and meta‐analysis

“…Risk behaviors are in fact a core symptom of mania 39 and, importantly, they are also related to aggressive behaviors, 86 mediated by common factors such as affective temperaments 87,88 or childhood maltreatment. 89,90 Indeed there is evidence that risk-taking was dependent on current mood status, as scores were highest in people with BD who were currently manic compared to those who were currently depressed or euthymic. 91,92 Negative focus strategy, defined as over-emphasizing the negative aspects of an experience and predicting the worst possible outcome, and focusing on self-critical thoughts, blaming self or others for events/situations that are not the complete responsibility of the individual, 3 also appeared to be correlated positively with both polarities of BD.…”

Examining associations, moderators and mediators between childhood maltreatment, social functioning, and social cognition in psychotic disorders: a systematic review and meta-analysis

“…This Study protocol was registered on PROSPERO (CRD42020175244) and published elsewhere before completion of the study (Fares-Otero, Pfaltz, Rodriguez-Jimenez, Schäfer, & Trautmann, 2021 ). This review follows the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA 2020) guideline (Page et al, 2021 ) (see ST1 and ST2 in the supplement), the Meta-analysis of Observational Studies in Epidemiology (MOOSE) (Stroup et al, 2000 ) (see ST3 in the supplement), and the Enhancing the Quality and Transparency of Health Research (EQUATOR) (Altman, Simera, Hoey, Moher, & Schulz, 2008 ) reporting guidelines.…”

The effect of polygenic risk score and childhood adversity experiences on transdiagnostic symptom dimensions at first-episode psychosis: evidence for an affective pathway to psychosis

“…While this hypothesis has been explored by examining depressive symptoms and anxiety as mediators between trauma and psychosis both in general population 5 and clinical samples 29,31 , it has to the best of our knowledge never been explored in relation to how genetic load for depression can shape psychopathology in patients with psychosis. There is evidence suggesting that low level depressive symptoms (at a sub-diagnostic level) are important for the aetiopathogenesis of psychosis and outcome, as they contributes to impairment in reality testing therefore contributing to the emergence of low level symptoms of psychosis 32 and psychosis onset 32 ; Subclinical depressive symptoms often precede relapse during the course of psychosis and plays a role in functional outcomes 33,34 and of course suicidality 35 32 . Beyond the suggested importance of assessing subthreshold depressive symptoms for these reasons, our ndings also suggest that considering genetic load for depression may be a marker for a more severe psychopathological pro le in people with psychosis and trauma.…”