Childhood maltreatment and the menopause transition in a cohort of midlife New Zealand women

Cleland, Lana; McLeod, Geraldine F. H.; Dhakal, Bhubaneswor; Fenton, Anna; Welch, J.; Horwood, L. John; Boden, Joseph M.

doi:10.1097/gme.0000000000001976

Cited by 6 publications

(10 citation statements)

References 45 publications

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“…Only a few studies, however, have assessed the association between childhood adversity and age at menopause. Data from the 1977 New Zealand birth cohort showed that women at the age of 40 years who experienced severe forms of child sexual abuse were twice as likely to be perimenopausal or postmenopausal when compared with those who were not exposed to child sexual abuse 16 . In the same study, childhood physical punishment did not significantly increase the odds of being perimenopausal or postmenopausal 16 .…”

Section: Discussionmentioning

confidence: 83%

Associations between childhood adversity and age at natural menopause

Kling,

Saadedine,

Faubion

et al. 2023

Menopause

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Objective Adverse childhood experiences (ACEs) are reported in more than half of the women in the United States and have been shown to negatively impact the menopause experience. The objective of this study was to evaluate the association between ACEs and age at natural menopause. Methods This is a cross-sectional study conducted among participants of the Data Registry on the Experiences of Aging, Menopause, and Sexuality (DREAMS). The registry included women who were seen for consultations in the women's health clinic at Mayo Clinic, Rochester, between May 2015 and December 2016. Only postmenopausal women were included in this analysis. Childhood adversity was assessed with the validated ACE questionnaire. Age at natural menopause was self-reported. The association between ACEs and age at menopause was evaluated using a multivariable linear regression model adjusting for multiple confounders. Results A total of 350 women were evaluated. The mean age was 59.2 years, and a majority were White (92.9%), married/partnered (82%), and educated (91.2% with at least some college education). Women with a history of at least four ACEs were estimated to reach natural menopause 1.3 years sooner than women with no ACE in multivariable analysis, but the results were not statistically significant (95% confidence interval, −3.2 to 0.6; P = 0.18). Conclusions Although stressful life experiences such as ACEs may negatively influence health for midlife women, this study did not find an association with the age at natural menopause.

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Section: Discussionmentioning

confidence: 83%

Associations between childhood adversity and age at natural menopause

Kling,

Saadedine,

Faubion

et al. 2023

Menopause

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“…Model 1 was controlled for age at matching, race and ethnicity, maternal education level, and marital status. Model 2 was further adjusted for potential confounders based on prior knowledge, measured at diagnosis or reference year or 1 to 5 years prior, including category of BMI (underweight, normal weight, overweight, or obese), [36][37][38] age at menarche (continuous), [12][13][14] parity (0 to 1 or 2 or more children), smoking (never, past, or current), [15][16][17] alcohol drinking (0, 0.1 to 10, or more than 10 grams per day), [39][40][41] physical activity (continuous), [42][43][44] childhood abuse (yes or no), [9][10][11] vitamin D intake (by quantile), and calcium intake (by quantile). [45][46][47] We focused on the associations with early menopause and moderate or severe VMS in the following analyses.…”

Section: Discussionmentioning

confidence: 99%

“…Early natural menopause and bothersome vasomotor symptoms (VMS) are challenging issues during menopause transition. [6][7][8] PMDs, early menopause, and VMS share risk factors (eg, childhood abuse, [9][10][11] earlier pubertal development, [12][13][14] and smoking [15][16][17] ), suggesting common etiologies.…”

Section: Introductionmentioning

confidence: 99%

Premenstrual Disorders, Timing of Menopause, and Severity of Vasomotor Symptoms

Yang,

Valdimarsdóttir,

Manson

et al. 2023

JAMA Netw Open

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ImportanceAlthough premenstrual disorders (PMDs) end at menopause, it is unclear whether they are associated with the timing and symptom severity of menopause.ObjectiveTo prospectively examine whether women with PMDs have increased risks of early menopause and menopause-related vasomotor symptoms (VMS).Design, Setting, and ParticipantsThis population-based cohort study was nested in the Nurses’ Health Study II (data collected from questionnaire sent between June 1991 and June 2017). Analysis of menopause timing included participants who did not have natural or surgical menopause before study entry, while the analysis of VMS was restricted to women who provided information on VMS. Data were analyzed from August 2022 to March 2023.ExposuresPMDs were identified by self-reported diagnosis and confirmed with symptom questionnaires from 1991 to 2005. Participants were age-matched to women without PMD diagnoses and confirmed absence of or minimal premenstrual symptoms.Main Outcomes and MeasuresDuring follow-up through 2017, timing of natural menopause was assessed biennially, and VMS were assessed in 2009, 2013, and 2017. The association of PMDs with early menopause was assessed by Cox proportional hazards models and with VMS by logistic regression models.ResultsOf 1220 included women with PMDs, the median (IQR) age was 40.7 (37.3-43.8) years; of 2415 included women without PMDs, the median (IQR) age was 41.7 (38.3-44.8) years. The median (IQR) follow-up in this study was 20.3 (17.8-22-2) years. Early natural menopause (menopause before age 45 years) was reported by 17 women with PMDs (7.1 per 1000 person-years) and 12 women without PMDs (2.7 per 1000 person-years; adjusted hazard ratio, 2.67; 95% CI, 1.27-5.59). In addition, 795 women with PMDs (68.3%) and 1313 women without PMDs (55.3%) reported moderate or severe VMS (adjusted odds ratio, 1.68; 95% CI, 1.32-2.14). There was no observed association between PMDs and mild VMS (adjusted odds ratio, 0.99; 95% CI, 0.76-1.28).Conclusions and RelevanceIn this cohort study of US women, PMDs were associated with increased risks of early menopause and moderate or severe VMS. PMDs may be indicative of underlying physiology linked to early menopause and VMS, suggesting a phenotype observable during the reproductive years that may allow clinicians to target women at risk of earlier menopause and subsequent health risks later in the life course.

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“…Fewer population-based prospective studies have examined associations between CSA and outcomes in mid to late adulthood. In midlife (ages 31-44), data from the Christchurch Health and Development Study and (US) National Longitudinal Study of Adolescent to Adult Health show associations between CSA and higher risk for physical (Duncan et al, 2019), mental (Bell et al, 2019), sexual (Cleland et al, 2022), and economic problems (Assini-Meytin et al, 2022). In middle age, data from the 1958 (British) National Child Development Study (Power & Elliott, 2005) show associations between CSA and higher risk for premature mortality between ages 45 and 58 (Rogers et al, 2021), as well as specific indicators of poorer physical health (physical functioning and self-rated health, Archer et al, 2017;high glycated hemoglobin, Li et al, 2019; health risk behaviors and faster age-related gains in body mass index, Power et al, 2015), mental health (composite psychopathology measure, Clark et al, 2010;suicidal ideation, Stansfeld et al, 2017), and economic (lack of assets, benefit use, financial insecurity, and low socioeconomic status, Pinto Pereira et al, 2017) outcomes.…”

Section: Introductionmentioning

confidence: 99%

Childhood sexual abuse and pervasive problems across multiple life domains: Findings from a five-decade study

et al. 2022

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The aim of this study was to use longitudinal population-based data to examine the associations between childhood sexual abuse (CSA) and risk for adverse outcomes in multiple life domains across adulthood. In 937 individuals followed from birth to age 45y, we assessed associations between CSA (retrospectively reported at age 26y) and the experience of 22 adverse outcomes in seven domains (physical, mental, sexual, interpersonal, economic, antisocial, multi-domain) from young adulthood to midlife (26 to 45y). Analyses controlled for sex, socioeconomic status, prospectively reported child harm and household dysfunction adverse childhood experiences, and adult sexual assault, and considered different definitions of CSA. After adjusting for confounders, CSA survivors were more likely than their peers to experience internalizing, externalizing, and thought disorders, suicide attempts, health risk behaviors, systemic inflammation, poor oral health, sexually transmitted diseases, high-conflict relationships, benefit use, financial difficulties, antisocial behavior, and cumulative problems across multiple domains in adulthood. In sum, CSA was associated with multiple persistent problems across adulthood, even after adjusting for confounding life stressors, and the risk for particular problems incremented with CSA severity. The higher risk for most specific problems was small to moderate, but the cumulative long-term effects across multiple domains reflect considerable individual and societal burden.

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Childhood maltreatment and the menopause transition in a cohort of midlife New Zealand women

Cited by 6 publications

References 45 publications

Associations between childhood adversity and age at natural menopause

Associations between childhood adversity and age at natural menopause

Premenstrual Disorders, Timing of Menopause, and Severity of Vasomotor Symptoms

Childhood sexual abuse and pervasive problems across multiple life domains: Findings from a five-decade study

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