Childhood maltreatment and transdiagnostic connectivity of the default-mode network: The importance of duration of exposure

Valencia, Noel; Seeger, Fabian R.; Seitz, Katja I.; Carius, Lisa; Nkrumah, Richard O.; Schmitz, Marius; Bertsch, Katja; Herpertz, Sabine C.

doi:10.1016/j.jpsychires.2024.07.022

Journal of Psychiatric Research

2024

DOI: 10.1016/j.jpsychires.2024.07.022

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Childhood maltreatment and transdiagnostic connectivity of the default-mode network: The importance of duration of exposure

Noel Valencia,

Fabian R. Seeger,

Katja I. Seitz

et al.

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2024

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Cited by 2 publications

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Common and divergent neuroimaging features in major depression, posttraumatic stress disorder, and their comorbidity

Jiang,

Ferraro,

Zhao

et al. 2024

Psychoradiology

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Posttraumatic stress disorder (PTSD) and major depressive disorder (MDD) are common stress-related psychiatric disorders. Genetic and neurobiology research has supported the viewpoint that PTSD and MDD may possess common and disorder-specific underlying mechanisms. In this systematic review, we summarized evidence for the similarities and differences in brain functional and structural features of MDD, PTSD and their comorbidity, as well as the effects of extensively used therapies in patients with comorbid PTSD and MDD (PTSD + MDD). These functional magnetic resonance imaging (MRI) studies highlight the 1) shared hypoactivation in the prefrontal cortex during cognitive and emotional processing in MDD and PTSD, 2) higher activation in fear processing regions including amygdala, hippocampus and insula in PTSD compared to MDD, and 3) distinct functional deficits in brain regions involved in fear and reward processing in patients with PTSD + MDD relative to those with PTSD-alone. These structural MRI studies suggested that PTSD and MDD share features of reduced volume in focal frontal areas. The treatment effects in patients with PTSD + MDD may correlate with the normalization trend of structural alterations. Neuroimaging predictors of repetitive transcranial magnetic stimulation response in patients with PTSD + MDD may differ from the mono-diagnostic groups. In summary, neuroimaging studies to date have provided limited information about the shared and disorder-specific features in MDD and PTSD. Further research is essential to pave the way for developing improved diagnostic markers and eventually targeted treatment approaches for the shared and distinct brain alterations presented in patients with MDD and PTSD.

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Common and divergent neuroimaging features in major depression, posttraumatic stress disorder, and their comorbidity

Jiang,

Ferraro,

Zhao

et al. 2024

Psychoradiology

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Exploring the neural link between childhood maltreatment and depression: a default mode network rs-fMRI study

Lin,

Huang,

et al. 2024

Front. Psychiatry

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BackgroundChildhood maltreatment (CM) is increasingly recognized as a significant risk factor for major depressive disorder (MDD), yet the neural mechanisms underlying the connection between CM and depression are not fully understood. This study aims to deepen our understanding of this relationship through neuroimaging, exploring how CM correlates with depression.MethodsThe study included 56 MDD patients (33 with CM experiences and 23 without) and 23 healthy controls. Participants were assessed for depression severity, CM experiences, and underwent resting-state functional MRI scans. Independent Component Analysis was used to examine differences in functional connectivity (FC) within the Default Mode Network (DMN) among the groups.ResultsMDD patients with CM experiences exhibited significantly stronger functional connectivity in the left Superior Frontal Gyrus (SFG) and right Anterior Cingulate Cortex (ACC) within the DMN compared to both MDD patients without CM experiences and healthy controls. FC in these regions positively correlated with Childhood Trauma Questionnaire scores. Receiver Operating Characteristic (ROC) curve analysis underscored the diagnostic value of FC in the SFG and ACC for identifying MDD related to CM. Additionally, MDD patients with CM experiences showed markedly reduced FC in the left medial Prefrontal Cortex (mPFC) relative to MDD patients without CM experiences, correlating negatively with Childhood Trauma Questionnaire scores.ConclusionOur findings suggest that increased FC in the ACC and SFG within the DMN is associated with CM in MDD patients. This enhanced connectivity in these brain regions is key to understanding the predisposition to depression related to CM.

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Childhood maltreatment and transdiagnostic connectivity of the default-mode network: The importance of duration of exposure

Cited by 2 publications

References 68 publications

Common and divergent neuroimaging features in major depression, posttraumatic stress disorder, and their comorbidity

Common and divergent neuroimaging features in major depression, posttraumatic stress disorder, and their comorbidity

Exploring the neural link between childhood maltreatment and depression: a default mode network rs-fMRI study

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