Childhood multi-trajectories of shyness, anxiety and depression: Associations with adolescent internalizing problems

Zdebik, Magdalena A.; Boivin, Michel; Battaglia, Marco; Tremblay, Richard E.; Falissard, Bruno; Côté, Sylvana M.

doi:10.1016/j.appdev.2019.101050

Cited by 19 publications

(12 citation statements)

References 75 publications

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“…When controlling for postpartum anxiety and depression, similar relationships were seen between prenatal maternal anxiety and children’s functional brain connectivity, though significant regions included more areas of the right parietal lobe. Shyness is negatively correlated with functional connectivity between the left amygdala and the right inferior parietal lobule 34 , and prenatal maternal anxiety has been related to shy/inhibited behaviours 35 , 36 . While childhood shyness has been associated with internalizing behaviours and social phobia later in development, it has also been shown to be protective against generalized anxiety disorder and depression in girls 36 .…”

Section: Discussionmentioning

confidence: 99%

“…Shyness is negatively correlated with functional connectivity between the left amygdala and the right inferior parietal lobule 34 , and prenatal maternal anxiety has been related to shy/inhibited behaviours 35 , 36 . While childhood shyness has been associated with internalizing behaviours and social phobia later in development, it has also been shown to be protective against generalized anxiety disorder and depression in girls 36 . Decreased left amygdala—right parietal functional connectivity may underlie the relationship between maternal anxiety symptoms and childhood behaviours such as shyness.…”

Section: Discussionmentioning

confidence: 99%

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Prenatal and postnatal maternal anxiety and amygdala structure and function in young children

Donnici

Long

Dewey

et al. 2021

Sci Rep

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Anxiety symptoms are relatively common during pregnancy and are associated with behavioural problems in children. The amygdala is involved in emotion regulation, and its volume and function are associated with exposure to prenatal maternal depression. The associations between perinatal maternal anxiety and children’s amygdala structure and function remain unclear. The objective of this study was to determine associations between prenatal and postnatal maternal anxiety and amygdala structure and function in children. Maternal anxiety was measured during the second trimester of pregnancy and 12 weeks postpartum. T1-weighted anatomical data and functional magnetic resonance imaging data were collected from 54 children (25 females), between the ages of 3–7 years. Amygdala volume was calculated and functional connectivity maps were created between the amygdalae and the rest of the brain. Spearman correlations were used to test associations between amygdala volume/functional connectivity and maternal anxiety symptoms, controlling for maternal depression symptoms. Second trimester maternal anxiety symptoms were negatively associated with functional connectivity between the left amygdala and clusters in bilateral parietal regions; higher maternal anxiety was associated with increased negative connectivity. Postnatal maternal anxiety symptoms were positively associated with child amygdala volume, but this finding did not remain significant while controlling for total brain volume. These functional connectivity differences may underlie behavioral outcomes in children exposed to maternal anxiety during pregnancy.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Prenatal and postnatal maternal anxiety and amygdala structure and function in young children

Donnici

Long

Dewey

et al. 2021

Sci Rep

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“…Developmental trajectories of internalising problems followed a different temporal trend, with increased levels during early childhood and the beginning of middle childhood [43]. Children following high-chronic trajectories of externalising and internalising behaviours have been shown to be at risk of negative longterm outcomes, including peer victimisation [28,46], suicidal ideation and attempt [47,48], and substance use [30,43,49].…”

Section: Development Of Externalising and Internalising Behavioural Problemsmentioning

confidence: 99%

Cohort Profile: Quebec Longitudinal Study of Child Development (QLSCD)

Orri¹,

Boivin²,

Chen³

et al. 2020

Soc Psychiatry Psychiatr Epidemiol

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Purpose. The Quebec Longitudinal Study of Child Development (QLSCD) was designed to examine the long-term associations of preschool physical, cognitive, social, and emotional development with biopsychosocial development across childhood, adolescence, and young adulthood.Methods. QLSCD is an ongoing prospective cohort including 2120 singletons born in 1997/1998 in the Canadian province of Quebec. So far, data has been collected annually or every two years from child ages 5 months to 21 years. The cohort currently includes 1245 participants. Data available include a range of environmental (e.g., family characteristics, child behaviour, educational attainment, mental health), biological (e.g., hair cortisol, genetic, epigenetic), and administrative data.Results. QLSCD has contributed to the understanding of children's psychosocial development, including the development of physical aggression and anxiety. QLSCD articles have advanced scientific knowledge on the influence of early childhood factors on childhood, adolescent, and young adult mental health, including the effect of participation in early childcare on cognitive and behavioural development, the developmental origins of adolescent and young adult mental health problems and suicide risk, and the development of interpersonal difficulties (e.g., peer victimisation) from preschool years to adolescence. Conclusion.QLSCD has given major contributions to our understanding of the link between different aspects of child development and biopsychosocial development during the first two decades of life. Unique features include the presence of environmental, biological, and administrative data, long-term follow-up with frequent data collections, and use of data from multiple informants, including teachers, mothers, fathers, and the children themselves.

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“…Social withdrawal is an umbrella term for all behaviors leading to self-isolation from the peer group (Rubin, Coplan, & Bowker, 2009). While children who eventually outgrow their tendency to withdraw in social situations tend to do well in terms of socioemotional functioning, those who persist are at risk of developing long-term mental health problems, including anxiety, depression, and substance-use disorders (Tang et al, 2017;Zdebik et al, 2019). Evidence from longitudinal studies suggests that outcomes associated with social withdrawal are more dire for those who manifest this behavior over an extended period of time (Tang et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

Polygenic scores differentially predict developmental trajectories of subtypes of social withdrawal in childhood

Morneau‐Vaillancourt

Andlauer

Ouellet‐Morin

et al. 2021

Child Psychology Psychiatry

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Background: Children who consistently withdraw from social situations face increased risk for later socioemotional difficulties. Twin studies indicate that genetic factors substantially account for the persistence of social withdrawal over time. However, the molecular genetic etiology of chronic courses of social wariness and preference for solitude, two dimensions of social withdrawal, remains undocumented. The objectives of the present study were (a) to identify high-risk trajectories for social wariness and preference for solitude in childhood and (b) to examine whether falling on these high-risk trajectories can be predicted by specific polygenic scores for mental health traits and disorders and by a general polygenic predisposition to these traits. Methods: Teachers evaluated 971 genotyped children at five occasions (age 6 to 12 years) from two prospective longitudinal studies, the Quebec Newborn Twin Study and the Quebec Longitudinal Study of Child Development. Developmental trajectories for social wariness and preference for solitude were identified. We tested whether polygenic scores for attention deficit hyperactivity disorder, autism spectrum disorder, depression, loneliness, and subjective well-being, as well as a general mental health genetic risk score derived across these traits, were associated with the developmental trajectories. Results: Polygenic scores differentially predicted social wariness and preference for solitude. Only the loneliness polygenic score significantly predicted the high trajectory for social wariness. By contrast, the general mental health genetic risk score factor was associated with the trajectory depicting high-chronic preference for solitude. Conclusions: Distinct associations were uncovered between the polygenic scores, social wariness, and preference for solitude.

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Childhood multi-trajectories of shyness, anxiety and depression: Associations with adolescent internalizing problems

Cited by 19 publications

References 75 publications

Prenatal and postnatal maternal anxiety and amygdala structure and function in young children

Prenatal and postnatal maternal anxiety and amygdala structure and function in young children

Cohort Profile: Quebec Longitudinal Study of Child Development (QLSCD)

Polygenic scores differentially predict developmental trajectories of subtypes of social withdrawal in childhood

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