Childhood mycosis fungoides: A clinicopathologic study of 30 cases from Iran

Nasimi, Maryam; Kamyab, Kambiz; Aghahi, Tahereh; Fahim, Shabnam; Ghandi, Narges

doi:10.1111/ajd.13192

Cited by 8 publications

(14 citation statements)

References 10 publications

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“…Most of the studies report hypopigmented MF as the predominant variant accounting for almost 55-100% of the cases. 11,15,20,[30][31][32][33] Other common variants reported are the classical MF, which may account for 15-40% of the cases, 4,9,10,34,35 folliculotropic variant (3-36%), 4,9,11,34 and poikilodermatous MF (5-26%). 16,36 There are few uncommon variants which have been reported in children including pityriasis lichenoides chronica-like (PLC) MF, unilesional MF, pigmented purpuric dermatosis-like MF, granulomatous MF, ichthyosiform MF, hyperpigmented and intraoral presentation, inflammatory linear verrucous epidermal nevus-like MF, and pagetoid reticulosis, which may at times be difficult to diagnose at the initial presentation.…”

Section: Clinical Presentationmentioning

confidence: 99%

“…48,50 Among Fitzpatrick skin type IV to VI, hypopigmented MF is more commonly seen in children, and it usually presents at a younger age as compared to children with other variants of MF. 8,30,51…”

Section: Clinical Presentationmentioning

confidence: 99%

“…The majority of childhood MF cases are diagnosed at an early stage (IA, IB, IIA) 4,15,31,34 while advanced disease like stage IIB and beyond is rare and carries a poor prognosis 11,30 as they may end up reaching after a significant delay to the dermatologist or may be treated initially with some other close differential diagnosis as reported in one of the studies by Dulmage et al wherein a tumor stage of childhood MF was initially managed with incision & drainage. 52…”

Section: Stagementioning

confidence: 99%

“…In children, poor response to treatment with the persistence of hypopigmented, papulosquamous, and purpuric lesions should raise a suspicion with MF as a differential diagnosis. 30 The diagnosis of MF in children is thus based on the correlation of clinical, pathological, and, if necessary, additional tests such as radiology, flow cytometry, and molecular biological methods are useful. Invasive measures such as skin biopsy in case of children due to small age cause diagnostic difficulty and hence require a high degree of suspicion.…”

Section: Diagnosismentioning

confidence: 99%

“…62 The total number of treatment sessions can have a significant impact on the overall outcome, and a greater number of sessions (induction as well as maintenance) may be associated with prolonged remission and less relapses. 30 Literature review over a period of 16 years (2005-2020) revealed 17 studies on childhood MF with sample size of ≥3 which revealed an overall response rate (complete and partial resolution) of 91% with PUVA and 70% with NBUVB 4,6,10,30,41,63,64 (Table 3). The studies which did not report the specific number of cases who received either NBUVB or PUVA were not included.…”

Section: Treatmentmentioning

confidence: 99%

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Mycosis fungoides in pediatric population: comprehensive review on epidemiology, clinical presentation, and management

et al. 2022

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Mycosis fungoides (MF) is the most common type of cutaneous T‐cell lymphoma. However, it is rare in pediatric population. Most of the cases of pediatric MF present with hypopigmented patches and/or various other forms, which may often mimic common childhood dermatoses, thereby causing a delay in the diagnosis. There are no established treatment guidelines for pediatric MF. As the progression of childhood MF is extremely rare and it has an indolent course, it is usually diagnosed at an early stage (IA, IB, IIA), and hence phototherapy with a response rate of >80% is a well‐established effective treatment in children. However, as recurrences are frequently seen on stopping the therapies, a maintenance regimen and long‐term follow‐up is equally important. This article reviews the epidemiological factors, clinical presentations, diagnosis, and various treatment modalities used in pediatric MF. We analyzed and compared the data of almost 616 childhood MF cases from various studies undertaken from 1988 to 2021.

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Section: Clinical Presentationmentioning

confidence: 99%

Section: Clinical Presentationmentioning

confidence: 99%

Section: Stagementioning

confidence: 99%

Section: Diagnosismentioning

confidence: 99%

Section: Treatmentmentioning

confidence: 99%

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Mycosis fungoides in pediatric population: comprehensive review on epidemiology, clinical presentation, and management

et al. 2022

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Purpuric patches on the thighs of a boy

Grechin,

Law,

Collins

2024

JEADV Clinical Practice

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Primary cutaneous T‐cell lymphomas in childhood and adolescence

Wohlmuth-Wieser

2021

J Deutsche Derma Gesell

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Summary Primary cutaneous lymphomas are extranodal non‐Hodgkin lymphomas of T‐ or B‐ cell origin, that predominantly affect older patients but have been reported in all age groups and as early as in the first years of life. Diagnosis of cutaneous lymphomas is challenging and requires high clinical suspicion and close collaboration between dermatologists, pediatric oncologists and pathologists. Skin involvement of non‐Hodgkin lymphomas in children or adolescents can either be primary cutaneous or secondary due to an underlying nodal lymphoma. The most common primary cutaneous lymphomas encountered in children are of T‐cell origin, with mycosis fungoides being the most prevalent cutaneous T‐cell lymphoma, followed by CD30+ lymphoproliferative disorders. While cutaneous lymphomas share clinicopathologic characteristics between juvenile and adult forms, there are important differences in terms of clinical presentation, diagnosis and treatment. The hypopigmented variant of mycosis fungoides seems to be overrepresented in the pediatric age group. Prognosis and treatment of mycosis fungoides are stage dependent. The majority of children present with early‐stage disease and respond well to topical corticosteroids and phototherapy.

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Childhood mycosis fungoides: A clinicopathologic study of 30 cases from Iran

Cited by 8 publications

References 10 publications

Mycosis fungoides in pediatric population: comprehensive review on epidemiology, clinical presentation, and management

Mycosis fungoides in pediatric population: comprehensive review on epidemiology, clinical presentation, and management

Purpuric patches on the thighs of a boy

Primary cutaneous T‐cell lymphomas in childhood and adolescence

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