Childhood neglect predicts disorganization in schizophrenia through grey matter decrease in dorsolateral prefrontal cortex

Cancel, Aïda; Comte, Magali; Truillet, Romain; Boukezzi, Sarah; Rousseau, Pierre-François; Zendjidjian, Xavier; Sage, Thierry; Lazerges, P.; Guedj, Éric; Khalfa, S.; Azorin, Jean‐Michel; Blin, Olivier; Fakra, É.

doi:10.1111/acps.12455

Cited by 46 publications

(34 citation statements)

References 113 publications

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“…Twenty-one studies were conducted in clinical samples [four in First Episode of Psychosis (FEP) or early psychosis patients (Evans, Reid, Preston, Palmier-Claus, & Sellwood, 2015;Morgan et al, 2014;Peach, Alvarez-Jimenez, Cropper, Sun, & Bendall, 2019;Sun et al, 2018), three in Ultra High Risk (UHR) patients (Appiah-Kusi et al, 2017;McDonnell, Stahl, Day, McGuire, & Valmaggia, 2018;Thompson et al, 2016), 14 in non-FEP patients (Cancel et al, 2015;Chatziioannidis et al, 2019;Choi et al, 2015;Hardy et al, 2016;Isvoranu et al, 2017;Perona-Garcelán et al, 2012;Quidé, O'Reilly, Watkeys, Carr, & Green, 2018;Schalinski et al, 2019;Steenkamp, Weijers, Gerrmann Perona-Garcelán et al, 2014;Pinto-Gouveia, Matos, Castilho, & Xavier, 2014;Rössler, Ajdacic-Gross, Rodgers, Haker, & Müller, 2016;Sheinbaum, Kwapil, & Barrantes-Vidal, 2014;Shevlin, McElroy, & Murphy, 2015;Sitko, Bentall, Shevlin, O'Sullivan, & Sellwood, 2014;van Nierop et al, 2014;Wolke, Lereya, Fisher, Lewis, & Zammit, 2014;Yamasaki et al, 2016)]. Our review included 82 352 subjects from the GP and 3189 subjects from clinical studies.…”

Section: Resultsmentioning

confidence: 99%

“…a We considered one analysis as 'supportive of mediation' when a significant mediation (partial, total or 'suggested') was found, and negative when null mediation was found. indirect effects, relying on small samples, and/or cross-sectional data (Cancel et al, 2015;Quidé et al, 2018). Overall, only 4/47 studies (Fisher et al, 2013;Lincoln et al, 2017;Thompson et al, 2016;Wolke et al, 2014) used a prospective design.…”

Section: Resultsmentioning

confidence: 99%

“…Pathway 5: biological measures Despite the high emphasis put on the search for biomarkers during the last 20 years of psychiatric research, we could identify just two eligible papers exploring biological mechanisms using psychosis as an outcome (Cancel et al, 2015;Quidé et al, 2018). This highlights the limited evidence in this field and the need for future studies testing mediation in longitudinal samples.…”

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confidence: 99%

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A systematic review on mediators between adversity and psychosis: potential targets for treatment

et al. 2020

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Various psychological and biological pathways have been proposed as mediators between childhood adversity (CA) and psychosis. A systematic review of the evidence in this domain is needed. Our aim is to systematically review the evidence on psychological and biological mediators between CA and psychosis across the psychosis spectrum. This review followed PRISMA guidelines. Articles published between 1979 and July 2019 were identified through a literature search in OVID (PsychINFO, Medline and Embase) and Cochrane Libraries. The evidence by each analysis and each study is presented by group of mediator categories found. The percentage of total effect mediated was calculated. Forty-eight studies were included, 21 in clinical samples and 27 in the general population (GP) with a total of 82 352 subjects from GP and 3189 from clinical studies. The quality of studies was judged as ‘fair’. Our results showed (i) solid evidence of mediation between CA and psychosis by negative cognitive schemas about the self, the world and others (NS); by dissociation and other post-traumatic stress disorder symptoms; and through an affective pathway in GP but not in subjects with disorder; (iii) lack of studies exploring biological mediators. We found evidence suggesting that various overlapping and not competing pathways involving post-traumatic and mood symptoms, as well as negative cognitions contribute partially to the link between CA and psychosis. Experiences of CA, along with relevant mediators should be routinely assessed in patients with psychosis. Evidence testing efficacy of interventions targeting such mediators through cognitive behavioural approaches and/or pharmacological means is needed in future.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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confidence: 99%

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A systematic review on mediators between adversity and psychosis: potential targets for treatment

et al. 2020

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“…However, they should be taken into account in future research. Contrary to our expectations, only two papers 40,41 fulfilled our inclusion criteria examining biological mediators. There is evidence that potential biological mediators are associated with adversity and with psychosis, but very few considering mediation effects directly.…”

Section: Discussionmentioning

confidence: 63%

A Systematic Review on Psychological and Biological Mediators Between Adversity and Psychosis: Potential Targets for Treatment

Alameda

Rodríguez

Carr

et al. 2019

Preprint

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Various psychological and biological pathways have been proposed as mediators between childhood adverse events (CA) and psychosis. A systematic review of the evidence in this domain is needed. The aim of this work is to systematically review the evidence on psychological and biological mediators between CA and psychosis across the psychosis spectrum. This systematic review followed Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines (registration number: CRD42018100846). Articles published between 1979 and July 2019 were identified through a literature search in OVID (PsychINFO; Medline and Embase). The evidence by each analysis and each study results are presented by group of mediator categories found in the review. The percentage of total effect mediated was calculated. 47 studies were included, with a total of 79,668 from general population (GP) and 3,189 from clinical samples. The quality of studies was judged as 'fair'. Our results showed (i) solid evidence of mediation between CA and psychosis by negative cognitive schemas about the self, the world, and others (NS); by dissociation and other PTSD symptoms; (ii) evidence of al mediation through an affective pathway (affective dysregulation, anxiety, and depression) in GP; (iii) lack of studies exploring biological mediators. To conclude, we found evidence suggesting that various overlapping and not competing pathways contribute partially to the link between adversity and psychosis. Experiences of adversity, along with relevant mediators such as PTSD and mood related symptoms and NS, should be routinely assessed in patients with psychosis. Targeting such mediators through cognitive behavioural aproaches using trauma-focused therapy and/or pharmacological means could be a useful addition to the traditional treatment of positive symptoms.

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“…Abnormal prefrontal-amygdala connectivity has also been associated with both maternal deprivation (Gee et al 2013) and disruptive behavior disorder (Marsh et al 2011). Furthermore, support has been documented for a causal model in which emotional (but not physical) neglect is associated with reduced dorsolateral prefrontal grey matter density, which is in turn associated with higher disorganized schizophrenia symptoms (Cancel et al 2015). A further study comparing children who experienced varying levels of early stress (i.e., early caregiving neglect while living in institutions for orphaned or abandoned children, children from low socioeconomic status households, and children who were victims of physical abuse)…”

Section: Specificity Sleeper Effects and Cognitive-nutritional Paritymentioning

confidence: 99%

The effect of being left home alone at age 3 years on schizotypy and antisocial behavior at ages 17 and 23 years

Wong

Raine

Venables

2018

Journal of Psychiatric Research

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Childhood neglect predicts disorganization in schizophrenia through grey matter decrease in dorsolateral prefrontal cortex

Abstract: Our findings suggest that EN during childhood could have an impact on psychopathology in schizophrenia, which would be mediated by developmental effects on brain regions such as the DLPFC.

Cited by 46 publications

References 113 publications

A systematic review on mediators between adversity and psychosis: potential targets for treatment

A systematic review on mediators between adversity and psychosis: potential targets for treatment

A Systematic Review on Psychological and Biological Mediators Between Adversity and Psychosis: Potential Targets for Treatment

The effect of being left home alone at age 3 years on schizotypy and antisocial behavior at ages 17 and 23 years

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