Childhood non-Hodgkin's lymphoma— a study of 17 cases in Israel

Aghai, E; Hulu, N; Virág, I; Kende, G.; Ramot, Bracha

doi:10.1002/1097-0142(197405)33:5<1411::aid-cncr2820330527>3.0.co;2-3

Cited by 14 publications

(3 citation statements)

References 19 publications

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“…Pathological examination of the tumor revealed a malignant lymphoma resembling Burkitt's tumor. The clinical and histological characteristics of this " Burkitt-like " tumor occurring in Israeli children ( H u h et al, 1970;Sachs et al, 1973;Aghai et al, 1974) are indistinguishable from those of the so-called American Burkitt tumors (Dorfman, 1968;Carbone et al, 1969;Cohen et al, 1969) and similar childhood lymphomas in many European and Asian countries (Ahlstrom et al, 1967;Aramsri et al, 1967;Bound and Murray, 1967;Shanmugaratram et al, 1967).…”

Section: Discussionmentioning

confidence: 99%

Establishment in continuous culture of a new type of lymphocyte from a “burkitt‐like” malignant lymphoma (line d.g.‐75)

Ben‐Bassat

Goldblum

Mitrani

et al. 1977

Intl Journal of Cancer

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261

140

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The isolation and establishment in vitro of a hitherto undescribed type of lymphocyte designated D.G.-75 is reported. The original inoculum was derived from the pleural effusion of a child with a primary abdominal lymphoma, which clinically and histologically resembled Burkitt's lymphoma. In addition to the absence of the EBV genome and EBV receptors, this line possesses a number of other properties which distinguish it from previously described lymphoblastoid cell lines. It has different growth characteristics and morphology; does not form EAC or E rosettes (representative of B and T) cell surface markers, respectively); possesses IgM-kappa immunoglobulins on the cell surface (B lymphocyte), has an unusually high cap-forming ability and low agglutinability with fluorescent concanavalin A. One homologue of the No.14 chromosome pair possesses extra chromatin material as revealed on chromosome banding. This abnormal chromosome marker is similar to that described in biopsies and cultured tumor cells from patients with African Burkitt's lymphoma.

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Section: Discussionmentioning

confidence: 99%

Establishment in continuous culture of a new type of lymphocyte from a “burkitt‐like” malignant lymphoma (line d.g.‐75)

Ben‐Bassat

Goldblum

Mitrani

et al. 1977

Intl Journal of Cancer

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261

140

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“…It is also interesting that in Israel, Burkitt's lymphoma appears to affect the same ethnic groups. 2 The incidence of H.D. in Arab and Oriental Jewish children is definitely high, with a distinct histologic pattern, M.C.…”

Section: Discussionmentioning

confidence: 99%

Childhood hodgkin's disease in israel: A study of 17 cases

Aghai

Brenner

Ramot

1975

Cancer

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“…More detailed data on Arab cases living in Palestine have been published (Hulu et al, 1970;Aghai et al, 1974;Gotlieb-Stematsky et al, 1976;Goldblum et al, 1977;Buchner et al, 1978;Selzer 504 Y. LADJADJ et al et al, 1979a, b;Prokocimer et al, 1980), but no significant survival study could be found.…”

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confidence: 99%

Abdominal Burkitt-type lymphomas in Algeria

Ladjadj¹,

Philip²,

Lenoir³

et al. 1984

Br J Cancer

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In a previous retrospective analysis from the principal paediatric centres of Algeria, Burkitt-type lymphomas (BL) were shown to account for around 46.5% of the total childhood non-Hodgkin's malignant lymphomas in that country. In the present study, a series of 49 abdominal BL from the Paediatric Clinic of Surgery, Mustapha Hospital, Algiers, has been studied. The age distribution shows a peak between 4 and 5 years of age, and the sex ratio is (M:F) 2.26:1. The disease is characterized by a rapid evolution in the absence of therapy. The major problem is an explosive form of the disease, which at present seems difficult to control in this country. Fifteen of the 49 patients (30.6%) died before completion of the first course of chemotherapy; however, complete remission (CR) was obtained for 30 patients (61%). Overall survival was 42.85% (21/49), whereas survival of patients who reached CR is 70% (21/30). When CR was obtained, deaths were related to cerebrospinal fluid involvement, local recurrence, secondary bone marrow involvement or therapeutic accidents. All patients alive with no evidence of disease (NED) 8-months after CR can be considered definitively cured. Epstein-Barr virus (EBV) serology performed on 31 BL patients and on a control group of 25 children with other malignant tumours showed that most Algerian BL have elevated EBV titres. A search for viral markers within malignant cells in 17 patients indicated that 88% (15/17) of the BL cases were EBV-associated. Analysis of the immunological and cytogenetic data showed that, as in the rest of the world, these BL cases involve proliferation of B-cell-type lymphocytes, with characteristic cytogenetic translocations involving chromosome 8. This report represents the most detailed description so far of BL from an area in non-equatorial Africa and the first report of a large series from North Africa.

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Childhood non-Hodgkin's lymphoma— a study of 17 cases in Israel

Cited by 14 publications

References 19 publications

Establishment in continuous culture of a new type of lymphocyte from a “burkitt‐like” malignant lymphoma (line d.g.‐75)

Establishment in continuous culture of a new type of lymphocyte from a “burkitt‐like” malignant lymphoma (line d.g.‐75)

Childhood hodgkin's disease in israel: A study of 17 cases

Abdominal Burkitt-type lymphomas in Algeria

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