Childhood obesity and hypertension in pregnancy: a two-sample Mendelian randomization analysis

Hu, Bing; He, Xin; Li, Fēi; Sun, Yanfang; Sun, Jun; Li, Feng

doi:10.1097/hjh.0000000000003442

Cited by 7 publications

(2 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Leptin also appears to exert a critical effect in the enhancement of hypertension in obese pregnancy [64]. A causality impact of genetically predisposed childhood obesity with the probability of hypertension in pregnancy has also been identified [65].…”

Section: Discussionmentioning

confidence: 99%

Association of Gestational Hypertension with Sociodemographic and Anthropometric Factors, Perinatal Outcomes, Breastfeeding Practices, and Mediterranean Diet Adherence: A Cross-Sectional Study

Pavlidou,

Papadopoulou,

Alexatou

et al. 2023

Medicina

View full text Add to dashboard Cite

Background and Objectives: Gestational hypertension has been associated with several pregnancy short-term and long-term complications, affecting both the mother and her infant’s health. The present study aims to assess the potential association of gestational hypertension with sociodemographic and anthropometry factors, perinatal outcomes, breastfeeding habits, and Mediterranean diet (MD) compliance. Materials and Methods: This is a cross-sectional study conducted on 5271 mothers that was carried out after delivery. The anthropometry characteristics and perinatal outcomes were retrieved from the mothers’ medical records. Sociodemographic characteristics, MD adherence, and breastfeeding habits were assessed via one-to-one interviews of the assigned women with qualified staff. Results: Maternal older age, being employed, family history of gestational hypertension, overweight/obesity before gestation, and abnormal gestational weight gain (GWG) independently increased the risk of developing gestational hypertension. Moreover, gestational hypertension was independently related with a greater incidence of abnormal childbirth body weight and preterm birth, not exclusively breastfeeding, and lower levels of MD adherence. Conclusions: This study highlights the importance of informing future mothers about the risk factors of gestational hypertension, underlining also that a healthy lifestyle, which simultaneously includes a healthy nutritional pattern such as MD, may decrease the risk of developing gestational hypertension and the subsequent pregnancy complications.

show abstract

Section: Discussionmentioning

confidence: 99%

Association of Gestational Hypertension with Sociodemographic and Anthropometric Factors, Perinatal Outcomes, Breastfeeding Practices, and Mediterranean Diet Adherence: A Cross-Sectional Study

Pavlidou,

Papadopoulou,

Alexatou

et al. 2023

Medicina

View full text Add to dashboard Cite

show abstract

“…Literature searches were conducted to identify potential confounders related to pre-eclampsia that might affect the study outcomes. SNPs associated with these confounders were excluded to mitigate the impact of confounding factors on the results [26,27].…”

Section: Gwas Data Collection and Instrumental Variable Selectionmentioning

confidence: 99%

Exploring the Genetic Link Between COVID-19 Severity and Pre-eclampsia: The Role of NTSR1 Gene SNPs and Calcium Ion Transport

Li,

Shen,

Zheng

et al. 2024

Preprint

View full text Add to dashboard Cite

Introduction: The COVID-19 pandemic and pre-eclampsia both present significant health challenges worldwide, with emerging evidence suggesting a genetic interlinkage that could illuminate new therapeutic avenues. This study aims to explore the genetic relationship between the severity of COVID-19 and pre-eclampsia, with a focus on Single Nucleotide Polymorphisms (SNPs) in the NTSR1 gene and mechanisms of calcium ion transport. Method: We employed a combination of genetic epidemiology and molecular biology techniques, including comprehensive bibliometric analysis and Mendelian Randomization, to assess the correlation between specific SNPs related to the NTSR1 gene and the severity of both COVID-19 and pre-eclampsia. Result: Our findings reveal a significant genetic correlation between the severity of COVID-19 and pre-eclampsia, underscored by SNPs associated with the NTSR1 gene and calcium ion transport. This correlation suggests a shared genetic foundation that could exacerbate both conditions, providing insights into potential molecular interactions involved. Conclusion: The identification of shared genetic pathways between COVID-19 and pre-eclampsia highlights the importance of genetic insights in developing targeted therapeutic interventions. These results open up new avenues for the mitigation of these conditions, emphasizing the role of genetic epidemiology in shaping future healthcare strategies.

show abstract

Mendelian randomization analysis of the association between childhood overweight or obesity and gestational diabetes mellitus

Jiang,

Zhang,

Zhang

2024

Diabetes Obesity Metabolism

View full text Add to dashboard Cite

ObjectiveTo investigate the association between childhood overweight or obesity and gestational diabetes mellitus (GDM).MethodsData were sourced from the Genome‐Wide Association Studies database on childhood body mass index (BMI), with 39 620 samples and 8 173 382 single‐nucleotide polymorphisms (SNPs), and GDM, with 143 441 samples, including 12 332 GDM cases and 20 149 608 SNPs. Mendelian randomization (MR) was conducted, including inverse variance weighting (IVW), MR‐Egger regression, and the weighted median method. Statistical heterogeneity among SNPs was assessed using Cochran's Q test. MR‐Egger's intercept, the MR‐Pleiotropy RESidual Sum and Outlier (PRESSO) test, and funnel plots were used to evaluate pleiotropy. The leave‐one‐out method tested the robustness of the IVW results by excluding individual SNPs.ResultsFifteen SNPs highly related to childhood BMI were identified. IVW analysis indicated that higher childhood BMI is a significant risk factor for GDM (odds ratio 1.50 [95% confidence interval 1.20–1.87]; p < 0.001). The direction of the β value derived from the weighted median method analysis was consistent with that from the IVW analysis. Cochran's Q test showed statistical heterogeneity among SNPs highly related to childhood BMI (p = 0.001), thus prioritizing IVW analysis results. The MR‐Egger regression intercept, MR‐PRESSO test, and funnel plot analyses demonstrated no horizontal pleiotropy among SNPs highly related to childhood BMI. The leave‐one‐out analysis indicated that the MR analysis results were largely unchanged after the exclusion of individual SNPs.ConclusionElevated childhood BMI is associated with an increased risk of developing GDM, underscoring the need to address childhood obesity as a preventive strategy. Effective interventions to reduce childhood obesity could be crucial in mitigating this risk.

show abstract

Childhood obesity and hypertension in pregnancy: a two-sample Mendelian randomization analysis

Cited by 7 publications

References 34 publications

Association of Gestational Hypertension with Sociodemographic and Anthropometric Factors, Perinatal Outcomes, Breastfeeding Practices, and Mediterranean Diet Adherence: A Cross-Sectional Study

Association of Gestational Hypertension with Sociodemographic and Anthropometric Factors, Perinatal Outcomes, Breastfeeding Practices, and Mediterranean Diet Adherence: A Cross-Sectional Study

Exploring the Genetic Link Between COVID-19 Severity and Pre-eclampsia: The Role of NTSR1 Gene SNPs and Calcium Ion Transport

Mendelian randomization analysis of the association between childhood overweight or obesity and gestational diabetes mellitus

Contact Info

Product

Resources

About