Childhood Obesity is Associated with Both Atopy and Current Asthma

Visness, Cynthia M.; Daniels, Julie L.; Kaufman, Jennie; Yeatts, Karin; London, Stephanie J.; Siega-Riz, Anna-Maria; Calatroni, Agustin; Zeldin, Darryl C.

doi:10.1016/j.jaci.2008.12.246

Cited by 2 publications

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“…Weight gain is rarely listed as a side effect of the modern antihistamines; however, research still indicates a correlation between intake of antihistamines by adults, adolescents and children, and weight gain, development of obesity and signs of metabolic syndrome [10,11]. While multiple preclinical trials have shown secondgeneration antihistamines have negligible adverse effect on the CNS, they may contribute to weight gain by affecting dietary lipid absorption or lipid metabolism [12].…”

Section: Introductionmentioning

confidence: 99%

Assessing the effect of prolonged use of desloratadine on adipose Brillouin shift and composition in rats

Troyanova‐Wood

Gobbell

Meng

et al. 2020

Journal of Biophotonics

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Antihistamines, which are commonly used to treat allergic reactions, are known for their side effects, which contribute to weight gain. It is hypothesized that simultaneous Brillouin elastography and Raman spectroscopy can be used to detect changes in adipose tissue associated with a prolonged intake of desloratadine, a commonly used second generation antihistamine. White and brown adipose tissue samples were excised from adult rats following 16 weeks of daily administration of desloratadine. It was found that the prolonged intake of desloratadine leads to an increase in Brillouin shift in both adipose tissue types. Raman spectra indicate that antihistamine use reduces protein-to-lipid ratio in brown adipose tissue but not white adipose tissue, indicating the effect on adipose tissue is location-dependent.

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Section: Introductionmentioning

confidence: 99%

Assessing the effect of prolonged use of desloratadine on adipose Brillouin shift and composition in rats

Troyanova‐Wood

Gobbell

Meng

et al. 2020

Journal of Biophotonics

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“…In adults, abdominal obesity is associated with a greater risk of nonallergic, but not allergic, asthma [112] and the association appears to be stronger in females [113,114]. In children, the association between obesity and asthma appears to exist in both the absence and presence of allergy, however, evidence suggests the obese-asthma association may be stronger in allergic children [115]. While there is clear evidence supporting an association between obesity and asthma outcomes, evidence suggesting mechanisms is less clear.…”

Section: Obesity and Asthmamentioning

confidence: 99%

Dietary Interventions in Asthma

Scott¹,

Jensen²,

Wood³

2014

CPD

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Asthma is a chronic inflammatory disorder of the airways. The inflammatory response in asthma is heterogeneous. Allergen specific responses lead to activation of the acquired immune system, via a predominantly IL-5 mediated, eosinophilic pathway. Stimuli such as viruses and bacteria activate the innate immune system, via a predominantly IL-8 mediated, neutrophilic pathway. Asthma has also been demonstrated to involve a systemic inflammatory component. Glucocorticoids are the predominant pharmacological treatment used to control inflammation in asthma. However, compliance with medications can be compromised due to patient concerns about side effects. Hence dietary interventions that target the inflammatory response in asthma have great potential. Various aspects of dietary intake are known to modulate inflammation. Saturated fatty acids can induce an inflammatory response via activation of pattern recognition receptors. Omega-3 fatty acids can be anti-inflammatory, via mechanisms such as modification of eicosanoid production. Antioxidants can have anti-inflammatory effects as they scavenge free radicals, preventing activation of transcription factors including NF-κB. Chronic excess energy intake can lead to obesity, which augments inflammation due to the release of inflammatory mediators by adipose tissue. Here we review the role of these dietary components in asthma.

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Childhood Obesity is Associated with Both Atopy and Current Asthma

Cited by 2 publications

References 0 publications

Assessing the effect of prolonged use of desloratadine on adipose Brillouin shift and composition in rats

Assessing the effect of prolonged use of desloratadine on adipose Brillouin shift and composition in rats

Dietary Interventions in Asthma

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