Childhood-onset obsessive-compulsive disorder

Eichstedt, Julie A.; Arnold, Sharon

doi:10.1016/s0272-7358(99)00044-6

Cited by 132 publications

(83 citation statements)

References 63 publications

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“…[19][20][21][22] This hypothesis was emphasized in clinical studies reporting that OCD age of onset is bimodal. Before puberty, there is a peak among male patients.…”

Section: Early-onset Ocd Phenotypementioning

confidence: 99%

“…Before puberty, there is a peak among male patients. 19,20,23 During adolescence, there is an increase in the number of girls diagnosed with OCD, reaching a 1 : 1 sex ratio in adulthood. 24 As in adult patients, 22,25 high rates of comorbidity are seen in children and adolescents with OCD, and some studies report that 90% of patients in their OCD samples had at least one other neuropsychiatric diagnosis.…”

Section: Early-onset Ocd Phenotypementioning

confidence: 99%

“…The same group sequenced the LOD score peak region identified in this genome scan and found no evidence for a functional mutation in the SLC1A1 gene. 41 In sum, the early-onset phenotype is characterized by a male preponderance 24,42 , a higher frequency of compulsions not preceded by obsessions, 19,21 higher comorbidity with tics and TS 20,28 and worse response to monotherapy treatment with clomipramine or SRI. 21,35 Furthermore, the early-onset phenotype has been associated with increased familial loading for OCD.…”

Section: Early-onset Ocd Phenotypementioning

confidence: 99%

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Obsessive-compulsive disorder phenotypes: implications for genetic studies

et al. 2004

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Obsessive-compulsive disorder (OCD) clinical presentation is remarkably diverse, and can vary both within and across patients over time. This variability in the phenotypic expression has led to the hypothesis that OCD is a heterogeneous disorder and that this heterogeneity obscures the findings of clinical, natural history and treatment response studies and complicates the search for vulnerability genes. A complete understanding of what comprises OCD and the underlying etiological mechanisms will require a dramatic change in how the disorder is conceptualized. In this review, several different approaches that may represent the first steps in this reconceptualization are discussed. These approaches include (1) narrowing the phenotype to identify categorically defined more homogeneous and mutually exclusive subtypes of OCD, (2) considering OC symptom dimensions as quantitative components of the more complex OCD phenotype and (3) broadening the phenotype to include other etiologically related conditions. A combined dimensional approach within distinctive subgroups is proposed as probably the most effective in helping to identify the heritable components of OCD. By identifying heritable components of OCD, it should be possible to find genes for these separate components. The review continues with the illustration of the possible role of some epigenetic risk and protective factors in the OCD presentation and the relevance of examining associated traits and/or endophenotypes to enhance our ability to understand the genetic basis of OCD. To conclude, we discuss the variability in treatment outcome and the significance of the development of specific pharmacological and/or behavioral based therapies tailored to each of these phenotypes. Molecular Psychiatry (2005) 10, 258-275.

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“…[19][20][21][22] This hypothesis was emphasized in clinical studies reporting that OCD age of onset is bimodal. Before puberty, there is a peak among male patients.…”

Section: Early-onset Ocd Phenotypementioning

confidence: 99%

Section: Early-onset Ocd Phenotypementioning

confidence: 99%

Section: Early-onset Ocd Phenotypementioning

confidence: 99%

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Obsessive-compulsive disorder phenotypes: implications for genetic studies

et al. 2004

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“…Further, the DSM V separates hoarding compulsions into a new disorder, i.e., the 'Hoarding Disorder' . Some authors [4,9,[14][15][16] have distinguished between childhood-onset and adult-onset OCD. These authors suggest that childhood onset OCD signifies a phenomenologically and etiologically distinct subtype of OCD, bearing a close genetic connection to tic-disorders and probably sharing an analogous pathogenesis.…”

Section: Childhood Vs Adult Ocdmentioning

confidence: 99%

Obsessive Compulsive Disorder (OCD) In Childhood and Adolescence

Ch¹

2015

J Psychol Abnorm Child

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Obsessive Compulsive Disorder (OCD) is an anxiety disorder, characterized by repetitive unwanted obsessions and compulsions, with a prevalence of 0.5-1% to 4% in childhood and adolescence. The exact pathogenesis of OCD remains uncertain but multiple components such as hereditary/genetic, cognitive, biological, environmental and behavioral factors have been implicated. The aim of this review is to highlight the pathogenesis of OCD in childhood and adolescence, differentiate it from adult onset OCD and outline its assessment and management.

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“…In terms of sex differences, when compared with girls, boys with childhood-onset OCD have a higher rate of comorbid tic disorders (7), a higher frequency of compulsions not preceded by obsessions (16), and a greater genetic contribution to the disease, as shown in mono- and dizygotic twin studies (17). Some studies have provided evidence for pathophysiologically distinctive subtypes of OCD that vary according to symptoms that had their onset in childhood versus those that emerge de novo in adulthood (16,18,19). However, the evidence for distinct subtypes is scant, and longitudinal studies are currently being conducted to elucidate further the differences between childhood- and adult-onset OCD.…”

Section: Introductionmentioning

confidence: 99%

Children with obsessive-compulsive disorder: are they just “little adults”?

Kalra¹,

Swedo²

2009

J. Clin. Invest.

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Childhood-onset obsessive-compulsive disorder (OCD) affects 1%-2% of children and adolescents. It is characterized by recurrent obsessions and compulsions that create distress and interfere with daily life. The symptoms reported by children are similar to those seen among individuals who develop OCD in adulthood, and the two groups of patients are treated with similar symptom-relieving behavior therapies and medications. However, there are differences in sex ratios, patterns of comorbidity, and the results of neuroimaging studies that might be important. Here we review the diagnosis and treatment of childhood-onset OCD in light of pediatric and adult studies. We also discuss current knowledge of the pathophysiology of the disorder. Despite advances in this area, further research is needed to understand better the etiopathogenesis of the disorder and to develop new, more effective therapeutic options.

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Childhood-onset obsessive-compulsive disorder

Cited by 132 publications

References 63 publications

Obsessive-compulsive disorder phenotypes: implications for genetic studies

Obsessive-compulsive disorder phenotypes: implications for genetic studies

Obsessive Compulsive Disorder (OCD) In Childhood and Adolescence

Children with obsessive-compulsive disorder: are they just “little adults”?

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