Childhood-Onset Schizophrenia: The Severity of Premorbid Course

Alaghband-Rad, Javad; McKenna, K.F.; Gordon, Charles T.; Albus, Kathleen E.; Hamburger, Susan; Rumsey, Judith M.; Frazier, Jean A.; Lenane, Marge; Rapoport, Judith L.

doi:10.1097/00004583-199510000-00012

Cited by 209 publications

(88 citation statements)

References 54 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This meanwhile well-known fact was reported by Hollis (23) and Alaghband-Rad et al (1) for COS. Marked social withdrawal was found in about 65 % of COS patients.…”

Section: Discussionsupporting

confidence: 74%

The ESSEN study of childhood-onset schizophrenia: Selected results

Eggers

Bunk

Volberg

et al. 1999

European Child & Adolescent Psychiatry

View full text Add to dashboard Cite

show abstract

“…This meanwhile well-known fact was reported by Hollis (23) and Alaghband-Rad et al (1) for COS. Marked social withdrawal was found in about 65 % of COS patients.…”

Section: Discussionsupporting

confidence: 74%

The ESSEN study of childhood-onset schizophrenia: Selected results

Eggers

Bunk

Volberg

et al. 1999

European Child & Adolescent Psychiatry

View full text Add to dashboard Cite

show abstract

“…However, they still share some common features: they are both considered as developmental psychiatric disorders involving psychotic symptoms (according to DSM-IV-TR, the term «psychotic» has been defined conceptually as a loss of ego boundaries or a gross impairment in reality testing) with impairments in the same main behavioral domains (communication, social interactions, and stereotyped behaviors, interests or activities). Communication impairments, and more generally, abnormalities in cognitive development are reported in autistic disorder as well as in early onset schizophrenia (Alaghband-Rad et al 1995;Asarnow et al 1994;Baum and Walker 1995;Cantor et al 1982). These cognitive dysfunctions include attention, Table 1 DSM-IV-TR diagnostic criteria for autistic disorder A.…”

Section: Definitions Of Autistic Disorder and Schizophreniamentioning

confidence: 99%

“…Furthermore, retrospective studies conducted on patients with schizophrenia or longitudinal studies of children with autistic disorder reported frequent associations between these two disorders (antecedents of autistic disorder in the childhood of the schizophrenic group and appearance of schizophrenia in the autistic group) (Alaghband-Rad et al 1995;Bender and Faetra 1972;Jansen et al 2000;Van Engeland and Van Der Gaag 1994). However, other retrospective and longitudinal studies found no significant association between these two disorders (Larsen and Mouridsen 1997;Volkmar and Cohen 1991).…”

Section: Definitions Of Autistic Disorder and Schizophreniamentioning

confidence: 99%

Animal Models Relevant to Schizophrenia and Autism: Validity and Limitations

et al. 2006

View full text Add to dashboard Cite

Development of animal models is a crucial issue in biological psychiatry. Animal models provide the opportunity to decipher the relationships between the nervous system and behavior and they are an obligatory step for drug tests. Mouse models or rat models to a lesser extent could help to test for the implication of a gene using gene targeting or transfecting technologies. One of the main problem for the development of animal models is to define a marker of the psychiatric disorder. Several markers have been suggested for schizophrenia and autism, but for the moment no markers or etiopathogenic mechanisms have been identified for these disorders. We examined here animal models related to schizophrenia and autism and discussed their validity and limitations after first defining these two disorders and considering their similarities and differences. Animal models reviewed in this article test mainly behavioral dimensions or biological mechanisms related to autistic disorder or schizophrenia rather than providing specific categorical models of autism or schizophrenia. Furthermore, most of these studies focus on a behavioral dimension associated with an underlying biological mechanism, which does not correspond to the complexity of mental disorders. It could be useful to develop animal models relevant to schizophrenia or autism to test a behavioral profile associated with a biological profile. A multi-trait approach seems necessary to better understand multidimensional disorders such as schizophrenia and autism and their biological and clinical heterogeneity. Finally, animal models can help us to clarify complex mechanisms and to study relationships between biological and behavioral variables and their interactions with environmental factors. The main interest of animal models is to generate new pertinent hypotheses relevant to humans opening the path to innovative research.

show abstract

“…While there seems to be a clinical and neurobiological continuity between childhood-onset and adult-onset SZ, the childhood form presents with severe premorbid neurodevelopmental abnormalities in language or motor abilities, more severe impairment in social development, more cytogenetic anomalies, a higher degree of family history of schizophrenia and associated spectrum disorders, and finally a worse long-term course than adulthood schizophrenia (Alaghband-Rad et al 1995;Hollis 1995;Nicholson and Rapoport 1999;Kumra et al 2001;Remschmidt and Theisen 2005). These findings argue for a more severe early disruption of brain development and genetic variation in Dysbindin may be considered a liability to such a severe phenotype but not to the SZ phenotype typically present in a population of adult in-patients which our sample was based on.…”

Section: Discussionmentioning

confidence: 99%

Brief Report: No Association Between Premorbid Adjustment in Adult-Onset Schizophrenia and Genetic Variation in Dysbindin

Schirmbeck

Georgi

Strohmaier

et al. 2008

J Autism Dev Disord

View full text Add to dashboard Cite

Whereas Dysbindin is considered a schizophrenia vulnerability gene, there is no consistency of findings. Phenotype refinement approaches may help to increase the genetic homogeneity and thus reconcile conflicting results. Premorbid adjustment (PMA) has been suggested to aid the phenotypic dissection. Gornick et al. (J Autism Dev Disord 35:831-838, 2005) reported an association between Dysbindin and PMA in US-Caucasian individuals with childhood-onset psychosis. In a sample of 222 adult-onset schizophrenia inpatients from Germany, we could not detect an association between PMA and 36 SNPs in Dysbindin. Our results suggest that genetic variation in Dysbindin may not contribute to the schizophrenia phenotype with an onset beyond childhood. Further studies including even larger samples and more SNPs may be warranted to clarify the relationship between Dysbindin and PMA.

show abstract

Childhood-Onset Schizophrenia: The Severity of Premorbid Course

Cited by 209 publications

References 54 publications

The ESSEN study of childhood-onset schizophrenia: Selected results

The ESSEN study of childhood-onset schizophrenia: Selected results

Animal Models Relevant to Schizophrenia and Autism: Validity and Limitations

Brief Report: No Association Between Premorbid Adjustment in Adult-Onset Schizophrenia and Genetic Variation in Dysbindin

Contact Info

Product

Resources

About