Childhood Ovarian Juvenile Granulosa Cell Tumor

Abstract

Ovarian juvenile granulosa cell tumor (JGCT) is an extremely rare sex cord-stromal tumor that is most commonly encountered in prepubertal girls and young women. In this study, 3 cases of childhood JGCT are reported. The main causes of hospitalization were abnormal abdominal signs and syndromes. Imaging findings indicated masses with multiple cysts and solid components in the abdominal cavities. Diagnosis was confirmed by histopathology. Tumors were excised completely, and all cases have a good outcome in the follow-up (2 to 13 y) without any adjuvant chemotherapy or radiotherapy. This data suggests that children with JGCT might have a variety of initial clinical manifestations. Pathologic examination especially immunohistochemical staining could help to diagnose JGCT. For children, adjuvant treatment may not be necessary if the tumor can be excised completely in early stage.

The Multifaceted Granulosa Cell Tumours—Myths and Realities: A Review

“…GCTs in neonates, as in index 2, are a rare occurrence, with few reported cases in less than one year of age. Childhood ovarian juvenile-type GCT are also rarely reported [21]. A common misconception is that the two subclassifications of GCTs, adult-type GCT (AGCT) and juvenile-type GCT (JGCT), refer to the age of development.…”