Childhood pancreatic tumors: a single institution experience

Yu, David C.; Kozakewich, Harry P.; Perez‐Atayde, Antonio R.; Shamberger, Robert C.; Weldon, Christopher B.

doi:10.1016/j.jpedsurg.2009.07.078

Cited by 62 publications

(61 citation statements)

References 11 publications

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“…Similarly to other reports [3], the incidence of NET was 25%. NET can be either benign or malignant, and can be associated with specific syndromes if hormonally active.…”

Section: Discussionsupporting

confidence: 85%

“…Little is known about the natural history of these lesions and, as a result of their rarity, knowledge of their presentation accrues principally through institutional case series [3,4,7]. In our experience, only 20 cases were observed over a 20-year period, representing a small fraction (0.7%) of all surgical interventions performed for pancreatic neoplasms.…”

Section: Discussionmentioning

confidence: 91%

“…In the young population, pancreatic tumors encompass a heterogeneous spectrum of lesions which can arise both from exocrine and endocrine cells (table 3) [2,3,4]. Differently from adults, in whom ductal adenocarcinoma and cystic tumors are predominantly seen, PB and SPT are the most common histotypes in the first and second decade [1,4,7].…”

Section: Discussionmentioning

confidence: 99%

“…In contrast to adults, pancreatic tumors in children and adolescents seldom arise from the ductal epithelium [2]. The most common histotypes are pancreatoblastoma (PB) and solid pseudopapillary tumors (SPT), but other different histotypes, including acinar cell carcinoma and neuroendocrine tumors (NET), have also been described [3]. The very limited experience, together with the broad histological heterogeneity, has made it difficult to identify possible prognostic factors and develop treatment protocols.…”

Section: Introductionmentioning

confidence: 99%

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Surgical Treatment of Pancreatic Tumors in Childhood and Adolescence: Uncommon Neoplasms with Favorable Outcome

Marchegiani¹,

Crippa

Malleo³

et al. 2011

Pancreatology

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“…Similarly to other reports [3], the incidence of NET was 25%. NET can be either benign or malignant, and can be associated with specific syndromes if hormonally active.…”

Section: Discussionsupporting

confidence: 85%

Section: Discussionmentioning

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Surgical Treatment of Pancreatic Tumors in Childhood and Adolescence: Uncommon Neoplasms with Favorable Outcome

Marchegiani¹,

Crippa

Malleo³

et al. 2011

Pancreatology

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“…However, in the pediatric literature, metastases or recurrences are extremely rare (14,23,24). Therefore, these tumors may be considered as different entities in pediatric and adult patients.…”

Section: Discussionmentioning

confidence: 99%

Radical resection of the pancreas should not always be necessary in the surgical management of pancreatic solid pseudopapillary tumor in children

Divarcı

Dökümcü²,

Çetingül³

et al. 2017

Turk J Gastroenterol

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Background/Aims: Pancreatic solid pseudopapillary tumor (SPT) is a rare neoplasm in children. In this study, we aimed to present our surgical strategy based on minimal resection by enucleation or limited resection in localized pancreatic SPT. Materials and Methods: We retrospectively analyzed the medical records of children who underwent surgical resection between October 2011 and September 2016. Results: Five female patients with a median age of 15 years (range, 14-17 years) were operated. Tumors were located in the pancreatic head (n=4) or tail (n=1). The median greatest tumor diameter was 9 cm (range, 5-13 cm). All the patients were investigated with MRI before the resection to demonstrate the relationship between the tumor and the main pancreatic duct. Patients underwent enucleation (n=4) for head localization or local distal resection without splenectomy (n=1) at the pancreatic tail. At postoperative follow-up, major pancreatic leakage was observed in two patients and endoscopically treated. Surgical margins were negative in all patients. The median follow-up period was 44 months (range, 2-59 months) and no local recurrence or distant metastasis was observed in the postoperative period. Conclusion: An optimal surgical strategy is still controversial in pancreatic SPT in children. Radical resections such as pancreaticoduodenoctomy or distal pancreatectomy with splenectomy result in loss of pancreatic tissue for endocrine and exocrine functions. Minimal resections such as enucleation or limited pancreatic resection with negative surgical margins should be performed in selected patients with no invasion to the main pancreatic duct or adjacent organs.

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Uncommon Tumors of the Gastrointestinal Tract in Children

Pappo

Furman

2012

Textbook of Uncommon Cancer

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Childhood pancreatic tumors: a single institution experience

Cited by 62 publications

References 11 publications

Surgical Treatment of Pancreatic Tumors in Childhood and Adolescence: Uncommon Neoplasms with Favorable Outcome

Surgical Treatment of Pancreatic Tumors in Childhood and Adolescence: Uncommon Neoplasms with Favorable Outcome

Radical resection of the pancreas should not always be necessary in the surgical management of pancreatic solid pseudopapillary tumor in children

Uncommon Tumors of the Gastrointestinal Tract in Children

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