Childhood Periodic Syndromes

Cuvellier, J.; Lépine, Anne

doi:10.1016/j.pediatrneurol.2009.07.001

Cited by 84 publications

(78 citation statements)

References 58 publications

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“…[1][2][3] It is a childhood periodic syndrome categorized in the main document of the International Classification of Headache Disorders, Third Edition. 4 BPT presents with recurrent stereotypic episodes of paroxysm of torticollis during infancy.…”

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confidence: 99%

“…6,7 BPT is more prevalent in girls (∼70%), and most episodes occur in the morning. 1,8 These episodes usually begin between age 2 and 8 months, improve by age 2 years, and disappear by age 3 to 4 years. 1,5,9 As the child grows up, the attacks disappear, but they may be replaced by a modified form, including attacks of ataxia, benign paroxysmal vertigo of childhood, and, later in childhood, by migraine, other childhood periodic syndromes, or motion sickness disease.…”

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confidence: 99%

“…1,8 These episodes usually begin between age 2 and 8 months, improve by age 2 years, and disappear by age 3 to 4 years. 1,5,9 As the child grows up, the attacks disappear, but they may be replaced by a modified form, including attacks of ataxia, benign paroxysmal vertigo of childhood, and, later in childhood, by migraine, other childhood periodic syndromes, or motion sickness disease. 1,6,7,10,11 Some of the nonheadache features of migraine such as vomiting, ataxia, pallor, irritability, malaise, apathy, drowsiness, photophobia, tears, nystagmus, and agitation may be associated with or rapidly follow the BPT attacks.…”

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confidence: 99%

“…1,5,9 As the child grows up, the attacks disappear, but they may be replaced by a modified form, including attacks of ataxia, benign paroxysmal vertigo of childhood, and, later in childhood, by migraine, other childhood periodic syndromes, or motion sickness disease. 1,6,7,10,11 Some of the nonheadache features of migraine such as vomiting, ataxia, pallor, irritability, malaise, apathy, drowsiness, photophobia, tears, nystagmus, and agitation may be associated with or rapidly follow the BPT attacks. 1, 4, 6-8, 12, 13 The presence of structural, genetic, and metabolic disorders should therefore be ruled abstract Benign paroxysmal torticollis (BPT) is a rare paroxysmal dyskinesia and 1 of the childhood periodic syndromes presenting with recurrent stereotypic episodes of torticollis, usually accompanied with some of the nonheadache features of migraine such as vomiting and ataxia.…”

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confidence: 99%

“…1,8,14 A family history of similar childhood syndrome, migraine, or motion sickness on the father's or mother's side is common. 6-8, 15, 16 Although >40 years have been passed since the initial description of BPT, there is no known treatment of the disease, and no clinical trials have been conducted.…”

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confidence: 99%

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The Efficacy of Topiramate in Benign Paroxysmal Torticollis of Infancy: Report of Four Cases

Yaghini

Badihian

2016

Pediatrics

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Benign paroxysmal torticollis (BPT) is a rare paroxysmal dyskinesia and 1 of the childhood periodic syndromes presenting with recurrent stereotypic episodes of torticollis, usually accompanied with some of the nonheadache features of migraine such as vomiting and ataxia. Although the nature of BPT may seem benign, its recurrent episodes can mimic attacks of epilepsy and expose the infant to unnecessary hospitalization and adverse effects of inappropriate medications. There is no approved medication for the disease, but a few studies have suggested that cyproheptadine is useful. However, use of this agent has not been confirmed as effective for these patients, and the safe dosage for children aged <2 years has not yet been established. We report 4 patients who exhibited a successful response to treatment with topiramate (their episodes of BPT stopped). Considering the underlying relation of BPT with migraine, the satisfactory response of our patients to topiramate, and the safety of this medication in neonates and children, topiramate seems to be an effective and safe medication for the reduction and elimination of BPT episodes. In addition, 1 of our case subjects (patient 4) confirmed this finding by exhibiting an explicit dependence in the regularity and duration of her attacks with topiramate. Topiramate seems to be an effective medication for the prophylaxis of BPT episodes. Further studies and clinical trials are recommended.

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confidence: 99%