Childhood Pre‐<scp>B</scp> acute lymphoblastic leukemia and glutathione S‐transferase omega 1 and 2 polymorphisms

Rezazadeh, Davood; Moradi, Mohammad‐Taher; Kazemi, Ahmad; Mansouri, Kamran

doi:10.1111/ijlh.12332

Cited by 5 publications

(13 citation statements)

References 30 publications

(40 reference statements)

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“…Persistent genital infections with different high-risk HPV genotypes, specifically HPV 16 and 18, lead to CIN and cervical cancer ( 1 , 21 , 22 , 23 ). It would seem that investigations should be performed on the recognition and development of genetic and epigenetic patterns as molecular prognostic biomarkers in the diagnosis of early stage of cervical cancer ( 15 , 24 ).…”

Section: Discussionmentioning

confidence: 99%

“…The GSTO enzyme is a new class in the GST super family which conjugated glutathione to electrophilic intermediates and detoxifies endogenous and exogenous compounds ( 15 , 25 , 26 ). GSTO1 is expressed in a wide range of human tissues and plays a role in apoptosis.…”

Section: Discussionmentioning

confidence: 99%

“…The gene encoding GSTO2 is a polymorphic gene with a single nucleotide polymorphism causing an asn142Asp (N142D) substitution. This substitution may alter the function of the GSTO2 enzyme ( 15 , 17 , 27 ). The allele frequencies of the GSTO2 N142D polymorphism in our study are similar to those reported by Rezazadeh et al ( 15 ) in comparison with Italy, Thailand, Japan, and Turkey.…”

Section: Discussionmentioning

confidence: 99%

“…In contrast, Ada et al reported no significant association between the GSTO1 A140D polymorphism and susceptibility to non-small cell lung cancer in the Turkish population ( 16 ). Also, Rezazadeh et al found that the frequency of GSTO1 A140D polymorphism was not associated with childhood pre-B acute lymphoblastic leukemia in the Iranian population ( 15 ).…”

Section: Discussionmentioning

confidence: 99%

“…The GST omega (GSTO) class belongs to the GST enzyme super family, which has a cysteine amino acid in its active site. Two actively transcribed GST genes (GSTO1 and GSTO2) are located on the long arm of chromosome 10, and both genes contain 6 exons ( 13 , 14 , 15 ).…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Glutathione S-transferase omega gene polymorphism as biomarker for human papilloma virus and cervical cancer in iranian women

Zamani

Sohrabi

Farzami

et al. 2018

J Turkish German Gynecol Assoc

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Objective:Human papillomavirus (HPV) infection is an important sexually-transmitted infection worldwide. Persistent infections with different high-risk HPV genotypes may cause cervical intraepithelial neoplasia and cervical cancer. Single nucleotide polymorphisms of glutathione S-transferase omega (GSTO) 1 and 2 play an important role in cancer progression. To evaluate GSTO gene polymorphism influence on women’s susceptibility to low-risk or high-risk HPV infections and also risk of cervical cancer development.Material and Methods:We examined 50 patients with cervical cancer, 43 patients who were positive for HPV, and 43 healthy individuals as negative controls. We used polymerase chain reaction-restriction fragment length polymorphism to determine GSTO1 A140D and GSTO2 N142D variants in study participants.Results:We found a significant association between the GSTO1 A140D gene polymorphism and HPV 6, 16, 18, 16/18 infections and cervical cancer in Iranian women. We noted a significant difference for the 140AD/142NN combination genotype between patients in the cervical cancer group and healthy controls. There were no significant differences for the GSTO2 N142D genotype and allele frequencies between the patient (i.e., cervical cancer and HPV-positive) groups and controls.Conclusion:The 140AD genotype, 140D allele, and 140AD/142NN combination genotype seem to confer a protective property in women’s susceptibility to HPV 6, 16, 18, 16/18 infections and cervical cancer. However, the GSTO2 N142D polymorphism is not associated with HPV infections and cervical cancer. It would appear that GSTO1 A140D SNPs likely play a role in the level of susceptibility to HPV-related cervical cancer.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Glutathione S-transferase omega gene polymorphism as biomarker for human papilloma virus and cervical cancer in iranian women

Zamani

Sohrabi

Farzami

et al. 2018

J Turkish German Gynecol Assoc

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Glutathione S‐transferase gene polymorphic sequence variations: Association with risk and response to Imatinib among Chronic Myeloid Leukemia patients of Kashmir

Baba

Shah

Pandith

et al. 2021

Int J Lab Hematology

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Introduction Glutathione S‐transferase (GST) gene deletion or polymorphic sequence variations lead to decreased enzyme activity that influences susceptibility and response to tyrosine kinase inhibitors in chronic myeloid leukemia (CML). We aimed to analyze relation of different GST gene sequence variants with susceptibility and response to Imatinib in CML. Material and Methods A total of 150 CML cases and equal number of age and gender matched healthy controls were genotyped for five GST polymorphisms by multiplex‐PCR and PCR‐RFLP techniques. BCR‐ABL1 transcripts were quantified by quantitative Real Time PCR (qRT‐PCR). Results GSTT1, GSTO1, and GSTO2 SNPs revealed no association, while as GSTM1null genotype was observed to protect against the development of CML (OR = 0.53, P = .01). GSTP1 variant genotypes AG (OR = 2.1, P = .003) and GG (OR = 5.6, P < .001), significantly associated with increased risk of CML. Combined genotype analysis showed protective impact of GSTT1present/GSTM1null (OR = 0.44, P = .003) while as GSTT1present/GSTP1‐GG (OR = 6.92, P < .001) and GSTM1present/GSTP1‐GG (OR = 6.33, P < .001), significantly increased CML risk. GSTM1null genotype individually and in combination with GSTT1present associated with superior rate of major molecular response (MMR) and event free survival (EFS) (log‐rank P = .029). GSTO2‐AG+GG genotype associated with significantly inferior MMR rates at 3, 6, and 12 months. Also, patients with GSTO2‐GG genotype showed significantly reduced EFS (log‐rank P = .025). Multivariate analysis confirmed GSTM1null as a better (HR:0.19, P = .029) and GSTO2‐GG genotype as an independent poor prognostic factor (HR:2.29, P = .037). Conclusion GSTM1null genotype seems to have a better prognostic role while GSTP1 variants significantly increase CML risk. Also, results support a correlation between disease outcome and GSTO2 polymorphism.

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The role of glutathione S-transferase omega gene polymorphisms in childhood acute lymphoblastic leukemia: a case-control study

Yassa

Arnaout

Botros

et al. 2021

Egypt J Med Hum Genet

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Background Acute lymphoblastic leukemia (ALL) is the most common childhood cancer. Glutathione-S-methyl transferase (GSTs) enzymes’ family is known to catalyze carcinogens detoxification. Overexpression of (GSTO) omega class was reported in cancer occurrence. The purpose of the study was to investigate the association of GSTO1*A140D (rs4925) and GSTO2*N142D (rs156697) polymorphisms with the susceptibility to childhood ALL and to evaluate their prognostic impact. Genotyping was performed using polymerase chain reaction-restriction fragment length polymorphism technique in 96 Egyptian pediatric ALL patients and 99 controls. Results No statistically significant different GSTO1*A140D genotype and allele distribution was observed among ALL cases and controls; however, a statistically significant different GSTO1*A140D genotype distribution was found between de novo ALL cases and controls [CC (37% vs. 56.6%), CA (47.8% vs. 40.4%), and AA (15.2% vs. 3.0%), respectively] (0.008). GSTO1*A140D variant genotypes’ frequency was significantly higher in de novo cases than in controls (63% vs. 43.4%) (0.028). The minor allele frequency (MAF) of GSTO1*A140D-A was significantly higher in de novo cases compared to controls (0.39 vs. 0.23) (0.005). Genotyping of GSTO2*N142D revealed a statistically significant difference of genotype distribution between ALL patients and controls [AA (26% vs. 36.3%), AG (62.5% vs. 61.6%), and GG (11.4% vs. 2.0%), respectively] (0.017) and between de novo ALL cases and controls [AA (37% vs. 36.3%), AG (45.7% vs. 61.6%), and GG (17.3% vs. 2.0%), respectively] (0.002). The MAF of GSTO2*N142D-G was significantly higher in ALL patients than in controls (0.42 vs. 0.32) (0.046). The high-risk ALL group had a higher frequency of GSTO1*A140D and GSTO2*N142D variant genotypes compared to corresponding wild genotypes and a higher frequency of combined polymorphisms compared to single polymorphisms and wild genotypes but with no statistically significant difference. Conclusion A statistically significant difference of GSTO1*A140D and GSTO2*N142D genotype distribution was detected between de novo ALL cases and controls. Compared to the control group, the MAF of GSTO1*A140D-A was overexpressed in de novo ALL cases and that of GSTO2*N142D-G was significantly higher in ALL patients. These findings suggest that the studied polymorphisms might play a significant role in the susceptibility to de novo childhood ALL in Egypt; however, GSTO1*A140D and/or GSTO2*N142D polymorphisms have no impact on ALL prognosis.

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Childhood Pre‐B acute lymphoblastic leukemia and glutathione S‐transferase omega 1 and 2 polymorphisms

Abstract: This study found no significant association between Pre-B ALL and GSTO1 A140D and GSTO2 N142D polymorphisms.

Cited by 5 publications

References 30 publications

Glutathione S-transferase omega gene polymorphism as biomarker for human papilloma virus and cervical cancer in iranian women

Glutathione S-transferase omega gene polymorphism as biomarker for human papilloma virus and cervical cancer in iranian women

Glutathione S‐transferase gene polymorphic sequence variations: Association with risk and response to Imatinib among Chronic Myeloid Leukemia patients of Kashmir

The role of glutathione S-transferase omega gene polymorphisms in childhood acute lymphoblastic leukemia: a case-control study

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