Childhood primary pulmonary neoplasms

Hancock, B.J.; Lorenzo, Maria Di; Youssef, Sami; Yazbeck, Salam; Marcotte, Jacques-Édouard; Collin, Pierre-Paul

doi:10.1016/0022-3468(93)90147-d

Cited by 209 publications

(159 citation statements)

References 45 publications

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“…Nevertheless, BCs are the most common primary lung neoplasms of childhood, 14 accounting for up to 80 % of malignant pulmonary neoplasms in paediatric populations. 18,19 Their incidence is apparently increasing, although this is probably related to the introduction of more sensitive diagnostic tools as well as to an overall increased awareness of this disease among physicians.…”

mentioning

confidence: 99%

Bronchial Carcinoid Tumours in Children — A Review

Rizzardi¹,

Bertolaccini²,

Terzi³

2011

European Oncology &Amp; Haematology

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Bronchial carcinoids (BCs) are rare, well-differentiated malignant neuroendocrine tumours that account for 2-5 % of all lung neoplasms in adults.In paediatric patients, carcinoids represent the most frequent primary lung cancer. Although BCs in childhood often have an endobronchial location causing airway obstruction, they are frequently misdiagnosed as benign conditions, resulting in a delay in definitive diagnosis and treatment. Surgery represents the treatment of choice for BCs, and lung-sparing resections (sleeve or bronchoplastic procedures) are recommended in central carcinoid tumours; pneumonectomy should be avoided, particularly in childhood. If promptly diagnosed and radically treated, BCs in children have an excellent prognosis. Relapses can occur many years after a radical resection, highlighting the necessity for long-term follow-up.

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mentioning

confidence: 99%

Bronchial Carcinoid Tumours in Children — A Review

Rizzardi¹,

Bertolaccini²,

Terzi³

2011

European Oncology &Amp; Haematology

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“…The ratio of primary tumours to metastatic to non-neoplastic lesions in pathologic changes arising from the lung in children is 1:5:60 [3]. The most common benign pulmonary tumour of the paediatric lung is inflammatory myofibroblastic tumour (52%), and the most common primary lung malignancies in children are pleuropulmonary blastoma and carcinoid tumour [4].…”

Section: Discussionmentioning

confidence: 99%

Primary Pleuropulmonary Synovial Sarcoma with Brain Metastases in a Paediatric Patient: An Unusual Presentation

Chirmade

Parikh

Anand

et al. 2017

Advances in Respiratory Medicine

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Primary lung neoplasms are rare in children. The most common primary lung malignancies in children are pleuropulmonary blastoma and carcinoid tumour. Synovial sarcoma (SS) accounts for approximately 1% of all childhood malignancies. In absolute terms, the SS of the lungs and pleura are extremely rare and pose a diagnostic difficulty. Soft tissue sarcomas usually have a high potential for metastases, however, metastasis to the brain is rare, even in widely disseminated disease, and it has been described only in 3 case reports previously. Primary pleuropulmonary SS with brain metastases is even rarer. Here we present a case of an 11-year-old boy who presented with respiratory complaints, viz. fever and cough for 20 days. Initial impression was lung abscess, however, on histopathological, immunohistochemical and molecular study, the disorder was diagnosed as synovial sarcoma. After a week from the first consult, the child developed neurological symptoms, viz., an episode of convulsion and gradually worsening power of the lower limb. Computed tomography scan and Magnetic Resonance Spectroscopy was suggestive of brain metastases. Given the rarity of primary lung neoplasms in children, clinical detection remains a challenge. Delayed diagnoses are common as respiratory symptoms may be attributed to inflammatory or infective processes. Primary pleuropulmonary synovial sarcoma is a rare tumour and it is not known to commonly metastasise to the brain. Though rare, primary pleuropulmonary SS should be considered an important differential among peadiatric primary lung neoplasms due to its potential for curability if detected early, and more aggressive metastatic pattern, e.g. brain metastases making early detection imperative.

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“…Some investigators suggest that bronchoscopic resection should be done for small lesions that are benign, according to the histological examination. 5) However, even though primary lung tumors in children are very rare, two-thirds of these tumors are malignant or potentially malignant. Therefore, bronchoscopic removal of these tumors is becoming more attractive along with simpler and less invasive procedures, though endoscopic excision does not guarantee radical excision and the tumor may recur locally or metastasize to a distant site.…”

Section: Discussionmentioning

confidence: 99%