Childhood Risk Factors and Pregnancy-Induced Hypertension: The Bogalusa Heart Study

Li, Shengxu; Xiong, Xu; Harville, Emily W.; Zhang, Tao; Sun, Dianjianyi; Fernandez, Camilo; Krousel‐Wood, Marie; Chen, Wei

doi:10.1093/ajh/hpw057

Cited by 8 publications

(6 citation statements)

References 40 publications

(41 reference statements)

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“…Overall, studies comparing pregnant and nonpregnant groups indicate pregnancy is associated with higher lipid levels 24 and lower blood pressure, especially early in pregnancy 25 . While our results are consistent with these, other studies have suggested that pre‐pregnancy blood pressure and lipids are associated with hypertensive disorders of pregnancy 26–29 . A recent study following 8899 pregnant women without diagnosed pre‐pregnancy hypertensive disorders found that early pregnancy blood pressures are predictive of hypertensive disorders of pregnancy in the second and third trimesters at a lower threshold than previously used 30 …”

Section: Discussionsupporting

confidence: 86%

Cardiovascular risk factors before and during pregnancy: Does pregnancy unmask or initiate risk?

Harville

Crook

Bazzano

et al. 2021

J of Obstet and Gynaecol

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Objectives: To understand if pregnancy unmasks previously silent cardiovascular (CV) adverse factors, or initiates lasting injury. Methods: Pre-pregnancy and during pregnancy CV risk factors (blood pressure, fasting lipids, and glucose) from 296 women belonging to studies in the International Childhood Cardiovascular Cohort (i3C) Consortium, a group of studies assessing the relationship between child and adolescent CV risk factors and adult outcomes, were used. Correlation coefficients between the pre-and during pregnancy measures were calculated, and the mean difference between the measures was modeled with adjustment for age, body mass index, race, smoking, and study. Results: Measures were strongly correlated at pre-and during-pregnancy visits (p < 0.01), with r of between 0.30 and 0.55. In most cases, the difference between pre-pregnancy and during-pregnancy did not differ significantly from 0 after adjustment for confounders. Stratification by gestational age indicated stronger correlations with measurements obtained during the first and second trimesters than the third. The correlation did not differ by the time elapsed between the pre-pregnancy and pregnancy visits. Conclusions: Pre-and during-pregnancy CV risk factors are moderately well correlated. This may indicate that susceptible women enter pregnancy with higher risk rather than pregnancy inducing new vascular or metabolic effects.

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Section: Discussionsupporting

confidence: 86%

Cardiovascular risk factors before and during pregnancy: Does pregnancy unmask or initiate risk?

Harville

Crook

Bazzano

et al. 2021

J of Obstet and Gynaecol

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“…5 In our study, 83% of the births occurred in this same period, and 17% between 1947 and 1963. Furthermore, multiples, stillbirths, and preterm births were, as expected, more common in preeclamptic pregnancies; preeclampsia was associated with age at menarche 21 and childhood overweight 9 in the expected direction, as well as with a lower probability of having subsequent children. 38 Although older participants had to recall whether they had had preeclampsia several decades after the event, the association with the mother's age at delivery was consistent across birth what allaying concerns about differential misclassification due to education.…”

Section: Limitations Of the Datasupporting

confidence: 68%

“…Women who have experienced preeclampsia (or other hypertensive disorders of pregnancy) have a higher incidence of subsequent cardiovascular disease . Preeclampsia and cardiovascular disease share numerous risk factors, including some that originate in early life, such as low birthweight, childhood overweight, short stature, and early age at menarche …”

Section: Introductionmentioning

confidence: 99%

Mother’s age at delivery and daughters’ risk of preeclampsia

Basso

Weinberg

D’Aloisio

et al. 2019

Paediatric Perinatal Epid

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Background Some cardiovascular disease risk factors are associated with both risk of preeclampsia and having been born to a younger or older mother. We examined whether mother's age at delivery predicts a primiparous daughter's risk of preeclampsia. Methods The analysis included 39 803 Sister Study participants (designated as “daughters”) born between 1930 and 1974. Using log‐binomial regression, we estimated relative risks (RR) of preeclampsia in the first pregnancy ending in birth (“primiparous preeclampsia”) associated with mother's age at the daughter’s birth. Models included: number of older full and maternal half‐siblings, income level growing up, daughter's age at delivery, race/ethnicity, and 5‐year birth cohort. We examined self‐reported relative weight at age 10 (heavier than peers versus not) as a potential effect measure modifier. Results Overall, 6.2% of daughters reported preeclampsia. Compared with those who had been born to 20‐24‐year old mothers, daughters of teenage mothers had a relative risk of 1.20 (95% confidence interval (CI) 1.01, 1.43) and daughters of mothers ≥25 had a ~10% lower risk. Relative weight at age 10 modified the association, with an inverse association between mother's age at delivery and preeclampsia seen only among daughters with low/normal childhood relative weight. In this subset, results were consistent across strata of daughter's age at menarche and age at first birth. Conclusions These findings, based on self‐reported data, require replication. Nevertheless, as women increasingly delay childbearing, they provide some reassurance that having been born to an older mother is not, per se, a risk factor for primiparous preeclampsia.

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“…Many studies have correlated high levels of leptin with the appearance of various types of cancer, such as the breast where leptin induces activity in aromatase, an enzyme responsible for transforming other steroids into estrogens within breast tissue, finding receptors for leptin in the breast cancer cells, evidence is also available on the relationship between hyperleptinemia and carcinoma of the colon, esophagus and prostate, representing an important line of research in the relationship between leptin and cancer (Li et al, 2016;Jéquier, 2002).…”

Section: Discussionmentioning

confidence: 99%

Relation Between Levels of Leptine and Metabolic Parameters in Children and Adolescents

Pérez-Álvarez¹,

Navarro²,

Garavito-Galofre³

et al. 2018

GJHS

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OBJECTIVE: To determine the relationship between leptin levels and metabolic parameters in children and adolescents. METHODS: Descriptive cross-sectional study. Laboratory biochemical values and anthropometric parameters were determined. Univariate analysis was performed with measurements of frequencies and percentages and bivariate analysis through statistical significance tests (p <0.05). In case of multiple comparisons, the Bonferroni correction was made. RESULTS: There were higher levels of leptin to higher adipose tissue, while in the metabolic parameters a relationship was observed between high levels of glycemia and leptin independent of the variables gender, age group and nutritional status. There was no clear relationship between high levels of leptin and those of the lipid profile. CONCLUSIONS: There was a relationship between leptin concentrations and nutritional status and in the relationship of leptin with the metabolic parameters studied, there was an association with glycemia, while this association was not clear with the lipid profile.

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Childhood Risk Factors and Pregnancy-Induced Hypertension: The Bogalusa Heart Study

Abstract: Elevated childhood BMI is a significant risk factor for PIH in adulthood, which underscores the importance of body weight control in childhood for prevention of PIH.

Cited by 8 publications

References 40 publications

Cardiovascular risk factors before and during pregnancy: Does pregnancy unmask or initiate risk?

Cardiovascular risk factors before and during pregnancy: Does pregnancy unmask or initiate risk?

Mother’s age at delivery and daughters’ risk of preeclampsia

Relation Between Levels of Leptine and Metabolic Parameters in Children and Adolescents

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