Childhood sexual trauma in women with interstitial cystitis/bladder pain syndrome; a case control study

Nickel, J. Curtis; Tripp, Dean A.; Pontari, Michel A.; Moldwin, Robert; Mayer, Robert; Carr, Lesley K.; Doggweiler, Ragi; Yang, Claire C.; Mishra, Nagendra; Nordling, Jørgen

doi:10.5489/cuaj.11110

Cited by 36 publications

(24 citation statements)

References 28 publications

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“…Prior individual studies of women with IC/BPS have indicated increased levels of anxiety and depression, catastrophizing, and childhood trauma compared to healthy controls [6, 7] [8, 15, 16]. It has been hypothesized that men with CP/CPPS may have similar difficulties but the case-control literature is very small [9] [10].…”

Section: Discussionmentioning

confidence: 99%

Widespread Psychosocial Difficulties in Men and Women With Urologic Chronic Pelvic Pain Syndromes: Case-control Findings From the Multidisciplinary Approach to the Study of Chronic Pelvic Pain Research Network

Naliboff

Stephens

Afari

et al. 2015

Urology

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Objectives To determine the extent, severity and sex differences of psychosocial deficits in men and women with urologic chronic pelvic pain syndromes (UCPPS), which in the past have been considered separate bladder (Interstitial Cystitis/Painful Bladder Syndrome) and prostate (Chronic Prostatitis/Chronic Pelvic Pain Syndrome) disorders. Evaluations of men and women separately suggest UCPPS is associated with increased anxiety and depression. However, studies directly testing deficits in broader psychosocial domains such as cognitive processes, intimate relationships and trauma history, or tests of sex differences in the pattern of difficulties associated with UCPPS have not been performed. Methods A total of 233 female and 191 male UCPPS patients and 235 female and 182 male healthy controls (HCs) were recruited from six academic medical centers in the US and evaluated with a comprehensive battery of symptom, psychosocial, and illness impact measures. Primary comparisons of interest were between UCPPS patients and HC, and between men and women with UCPPS. Results In addition to greater negative affect, male and female UCPPS patients show higher levels of current and lifetime stress, poorer illness coping, increased self-report of cognitive deficits and more widespread pain symptoms compared to sex and education matched HC. Similar problems were found in male and female UCPPS although female UCPPS showed increased self-report of childhood adversity and more widespread symptoms of pain and discomfort. Conclusions Given the significance of psychosocial variables in prognosis and treatment of chronic pain conditions, the results add substantially to our understanding of the breath of difficulties associated with UCPPS and point to important areas for clinical assessment.

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Section: Discussionmentioning

confidence: 99%

Widespread Psychosocial Difficulties in Men and Women With Urologic Chronic Pelvic Pain Syndromes: Case-control Findings From the Multidisciplinary Approach to the Study of Chronic Pelvic Pain Research Network

Naliboff

Stephens

Afari

et al. 2015

Urology

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“…In humans, although stress definitely plays a role in exacerbating the symptoms, its role as a causative factor is much less clear. 23, 24 In both humans and domestic cats, the number of co-morbidities that accompany IC seems to be a feature of a more system-wide disorder. Moreover, effective multimodal environmental modification for cats with FIC has been found to mitigate signs of comorbid disorders in both clinical and laboratory studies.…”

Section: Discussionmentioning

confidence: 99%

Abnormalities in Expression of Structural, Barrier and Differentiation Related Proteins, and Chondroitin Sulfate in Feline and Human Interstitial Cystitis

et al. 2015

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Purpose The urothelium of cats diagnosed with feline interstitial cystitis (FIC) was analyzed to determine if abnormalities in protein expression patterns could be detected, and whether the pattern of expression was similar to that observed in human Interstitial Cystitis/Bladder Pain Syndrome (IC) patients. The proteins that were analyzed are involved in cell adhesion, barrier function, comprise the glycosaminoglycan (GAG) layer, or are markers of differentiation. Methods Formalin-fixed biopsies from 8 cats with FIC and 7 healthy controls were labeled using immunohistochemistry and scored using a modified version of a system previously used for human samples. Cluster analysis was performed to investigate relationships between the markers and samples. Results The results showed that 89% of the FIC bladders displayed abnormal protein expression and chondroitin sulfate (CS) patterns, whereas only 27% of the normal tissues exhibited slight abnormalities. Abnormalities were found in most of the FIC samples, biglycan (87.5%), CS (100%), decorin (100%), E-cadherin (100%), keratin-20 (K20, 100%), uroplakin (50%), ZO-1 (87.5%). In the FIC bladders, about 75% of the CS, biglycan, and decorin samples displayed absence of luminal staining or no staining. Results from the cluster analysis revealed that the FIC and normal samples fell into two clearly separate groups, demonstrating that the urothelium of cats with FIC is altered from normal. Conclusions FIC produces similar changes in luminal GAG and several proteins as is seen in human patients, suggesting some commonality in mechanism and supporting the use of FIC as a model for human IC.

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“…Nine studies measured stress and coping by assessing catastrophic thought processes, 18,19,23-26 perceived stress, 9,23,24 and self-efficacy. 27,28 Catastrophizing, or an internal exaggeration of events, rumination, or sense of helplessness in response to pain, is consistently related to worsened outcomes in mental and physical functioning.…”

Section: Stress and Copingmentioning

confidence: 99%

“…Six studies measured abuse prevalence via validated selfreport, 5,9,24,29 non-validated questionnaires, 30,31 and clinical interview of trauma exposure. 30 One study measured dissociative tendencies.…”

Section: Trauma Sequelaementioning

confidence: 99%

“…5 Abuse in childhood and adulthood is more common in female patients. 9 The presence of sexual abuse has been associated with altered symptom presentation, where patients experiencing greater sensory pain, 24,31 less daytime frequency and nocturia, larger voided volumes, 31 and worsened sexual functioning 31,32 -although one study notes this relationship is at most very modest. 24…”

Section: Trauma Sequelaementioning

confidence: 99%

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Psychosocial co‐morbidities in Interstitial Cystitis/Bladder Pain syndrome (IC/BPS): A systematic review

McKernan

Walsh

Reynolds

et al. 2017

Neurourology and Urodynamics

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Aims Psychosocial factors amplify symptoms of Interstitial Cystitis (IC/BPS). While psychosocial self-management is efficacious in other pain conditions, its impact on an IC/BPS population has rarely been studied. The objective of this review is to learn the prevalence and impact of psychosocial factors on IC/BPS, assess baseline psychosocial characteristics, and offer recommendations for assessment and treatment. Method Following PRISMA guidelines, primary information sources were PubMed including MEDLINE, Embase, CINAHL, and GoogleScholar. Inclusion criteria included: (i) a clearly defined cohort with IC/BPS or with Chronic Pelvic Pain Syndrome provided the IC/BPS cohort was delineated with quantitative results from the main cohort; (ii) all genders and regions; (iii) studies written in English from 1995 to April 14, 2017; (iv) quantitative report of psychosocial factors as outcome measures or at minimum as baseline characteristics. Results Thirty-four of an initial 642 articles were reviewed. Quantitative analyses demonstrate the magnitude of psychosocial difficulties in IC/BPS, which are worse than average on all measures, and fall into areas of clinical concern for 7 out of 10 measures. Meta-analyses shows mean Mental Component Score of the Short-Form 12 Health Survey (MCS) of 40.80 (SD 6.25, N = 2912), where <36 is consistent with severe psychological impairment. Averaged across studies, the population scored in the range seen in clinical depression (CES-D 19.89, SD 13.12, N = 564) and generalized anxiety disorder (HADS-A 8.15, SD 4.85, N = 465). Conclusion The psychological impact of IC/BPS is pervasive and severe. Existing evidence of treatment is lacking and suggests self-management intervention may be helpful.

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Childhood sexual trauma in women with interstitial cystitis/bladder pain syndrome; a case control study

Cited by 36 publications

References 28 publications

Widespread Psychosocial Difficulties in Men and Women With Urologic Chronic Pelvic Pain Syndromes: Case-control Findings From the Multidisciplinary Approach to the Study of Chronic Pelvic Pain Research Network

Widespread Psychosocial Difficulties in Men and Women With Urologic Chronic Pelvic Pain Syndromes: Case-control Findings From the Multidisciplinary Approach to the Study of Chronic Pelvic Pain Research Network

Abnormalities in Expression of Structural, Barrier and Differentiation Related Proteins, and Chondroitin Sulfate in Feline and Human Interstitial Cystitis

Psychosocial co‐morbidities in Interstitial Cystitis/Bladder Pain syndrome (IC/BPS): A systematic review

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