WHAT'S KNOWN ON THIS SUBJECT: Short sleep may be an adolescent obesity risk factor, but most evidence is from crosssectional studies. Three longitudinal studies have investigated the association between sleep duration and adolescent obesity, finding mixed results.WHAT THIS STUDY ADDS: Shorter sleep was associated with increases in BMI from age 14 to 18, especially at the upper tail of the BMI distribution. Increasing daily sleep to 10 hours per day could help to prevent adolescent obesity. abstract OBJECTIVES: Short sleep has been associated with adolescent obesity. Most studies used a cross-sectional design and modeled BMI categories. We sought to determine if sleep duration was associated with BMI distribution changes from age 14 to 18.METHODS: Adolescents were recruited from suburban high schools in Philadelphia when entering ninth grade (n = 1390) and were followedup every 6 months through 12th grade. Height and weight were selfreported, and BMIs were calculated (kg/m 2 ). Hours of sleep were self-reported. Quantile regression was used to model the 10th, 25th, 50th, 75th, and 90th BMI percentiles as dependent variables; study wave and sleep were the main predictors.RESULTS: BMI increased from age 14 to 18, with the largest increase observed at the 90th BMI percentile. Each additional hour of sleep was associated with decreases in BMI at the 10th (-0.04; 95% confidence interval [CI]: -0.11, 0.03), 25th , and 90th (-0.27; 95% CI: -0.45, -0.09) BMI percentiles. The strength of the association was stronger at the upper tail of the BMI distribution. Increasing sleep from 7.5 to 10.0 hours per day at age 18 predicted a reduction in the proportion of adolescents .25 kg/m 2 by 4%.