Childhood Status Epilepticus: Current Status and Future Directions

Kalra, Veena

doi:10.1007/s13312-020-1749-2

Cited by 2 publications

(2 citation statements)

References 15 publications

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“…The types of seizures found in WD patients do not differ considerably from those observed in general population surveys; however, there is an increase in focal motor seizures (18). Multiple theories have been proposed for the pathophysiology of seizure activity in this disease, including direct toxicity due to inhibition of membrane ATPase, oxidative damage due to copper deposition, and chelation therapy leading to vitamin B6 de ciency (19). However, in our case, seizures were present even before starting penicillamine.…”

Section: Discussionmentioning

confidence: 59%

Wilson's Disease Masquerading as Acute Encephalitis: A Case Report

Kalwar,

Rid,

Ahsan

et al. 2024

Preprint

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Introduction: Wilson's disease (WD) is a rare autosomal recessive disorder characterized by copper accumulation in the liver, brain, and cornea, resulting from mutations in the ATP7B gene. Case Presentation: This case report presents a unique manifestation of WD, as a 14-year-old female from rural Pakistan presented with acute encephalitis and the ‘Face of the Giant Panda Sign’. Encephalitis is an uncommon initial presentation of WD, and this case highlights the diagnostic challenges, especially in resource-limited settings. The patient exhibited sudden-onset fever, generalized tonic-clonic seizures, and altered mental status. Initially misattributed to possession by the parents, the patient underwent empirical treatment for encephalitis in the hospital without improvement. Further evaluation revealed abnormal liver function, positive HepBsAg, and characteristic brain MRI findings indicative of WD. Confirmation was made through low ceruloplasmin, Kayser-Fleischer rings, and modified Leipzig criteria. Treatment with penicillamine and vitamin B6 resulted in clinical improvement. Conclusion This case emphasizes the importance of considering WD in cases of encephalitis, even in the absence of typical hepatic symptoms. The delay in diagnosis and initial misinterpretation underscore the need for increased awareness and education, particularly in regions with limited healthcare resources. Early recognition and intervention can prevent the progression of WD, improving patient outcomes. The report also underscores the significance of familial screening and long-term follow-up to manage the chronic nature of the disease. Further studies and reporting of atypical presentations contribute to the understanding and management of this rare and clinically heterogeneous disorder.

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Section: Discussionmentioning

confidence: 59%

Wilson's Disease Masquerading as Acute Encephalitis: A Case Report

Kalwar,

Rid,

Ahsan

et al. 2024

Preprint

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“…Globally, more than 4000 infants and young children die because they do not get colostrum within the first hour after birth. 23 Among women in developing countries who do not give colostrum feeds, most of them avoid colostrum feeding based on cultural beliefs that range from no nutritional value for infants to harmful to the infant's health. 24 Every day, 3000–4000 infants die in the developing world from diarrhea and acute respiratory infections because they were receiving inadequate amounts of breast milk in their feeding and were deprived of colostrum.…”

Section: Introductionmentioning

confidence: 99%

Colostrum Avoidance Practices and Its Associated Factors among Mothers of Children Aged Less Than 12 Months in Jinka Town, South Ethiopia, 2020. A Community Based Cross Sectional Study

Amaje

Gebremeskel

Tufa

et al. 2022

Health Services Research and Managerial Epidemiology

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Background Even though colostrum discarding hurts child health, little is known about the extent of the problem and its contributing factors in Southern Ethiopia. This study aimed to determine the prevalence of colostrum avoidance practices and associated factors among mothers of children aged less than 12 months in Jinka town, South Ethiopia. Methods A community-based cross-sectional study was conducted at Jinka Town from March 1 to 30, 2020. A total of 420 mothers having children less than 12 months of age were selected by systematic sampling technique. The data were collected by using pretested interviewer-administered and semi-structured questionnaires. The data was entered using EPI DATA 3.1 and exported to SPSS version 23 for analysis. Descriptive statistics, binary and multivariable logistic regression analysis were done. Adjusted odds ratio with 95% CI at a p-value < 0.05 was estimated to identify statistically significant variables with colostrum avoidance practices. Results The prevalence of colostrum avoidance practice was 9.8% [95% CI: (6.9–12.5)]. Delayed initiation of breastfeeding [AOR = 9.08(95% CI 4.16–19.83)], lack of breastfeeding counseling [AOR = 2.33(95% CI 1.11–4.87)], home delivery of index child [AOR = 2.48 (95% CI 1.16–5.27)] and poor knowledge on breastfeeding [AOR = 4.55(95% CI 1.95–10.63)] were factors associated with colostrum avoidance practices. Conclusion Colostrum avoidance practice among mothers of children aged less than 12 months in Jinka town was high. Delayed initiation of breastfeeding, lack of breastfeeding counseling, home delivery, and knowledge of breastfeeding practice were factors associated with colostrum avoidance practice.

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Childhood Status Epilepticus: Current Status and Future Directions

Cited by 2 publications

References 15 publications

Wilson's Disease Masquerading as Acute Encephalitis: A Case Report

Wilson's Disease Masquerading as Acute Encephalitis: A Case Report

Colostrum Avoidance Practices and Its Associated Factors among Mothers of Children Aged Less Than 12 Months in Jinka Town, South Ethiopia, 2020. A Community Based Cross Sectional Study

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