Childhood trauma and diagnosis of major depression: Association with memory and executive function

Kaczmarczyk, Michael; Wingenfeld, Katja; Kuehl, Linn K.; Otte, Christian; Hinkelmann, Kim

doi:10.1016/j.psychres.2018.10.071

Cited by 32 publications

(36 citation statements)

References 47 publications

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“…Despite high interrelations, it might be of interest to separate AG groups according to their individual types of abuse in the future (Cecil et al, 2017). However, separating AG from NG already goes beyond previous work (Aas et al, 2011;Kaczmarczyk et al, 2018;Majer et al, 2010;Miller et al, 2015) and constituted a strengh of the present work.…”

Section: Tablementioning

confidence: 81%

“…In one study on early-life stress, adopted adolescents (relative to adolescents residing with their biological parents) failed to exhibit monetary incentive related enhancement during inhibitory control (Mueller et al, 2012). However, while most available studies examined maltreatment in general without dividing the sample into subgroups (Aas et al, 2011;Kaczmarczyk, Wingenfeld, Kuehl, Otte, & Hinkelmann, 2018;Majer, Nater, Lin, Capuron, & Reeves, 2010;Miller et al, 2015), a few experimental studies have been able to demonstrate differences in outcome depending on the type of experienced maltreatment (Cowell, Cicchetti, Rogosch, & Toth, 2015;Cromheeke, Herpoel, & Mueller, 2014;Shipman, Edwards, Brown, Swisher, & Jennings, 2005).…”

Section: Introductionmentioning

confidence: 99%

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Reward prospect improves inhibitory control in female university students with a history of childhood sexual and physical abuse

Kiyar¹,

Lommen²,

Krebs³

et al. 2021

Journal of Behavior Therapy and Experimental Psychiatry

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Background and objectives: Childhood abuse and neglect increase the risk for psychiatric disorders (e.g., depression and anxiety) during adulthood and have been associated with deficits in cognitive control. The specific mechanisms underlying these cognitive control deficits are still unknown. Methods: This study examined the expectation for reward to improve inhibitory control in young women (ages 18-35 years) with a history of childhood sexual and/or physical abuse (AG, N = 28), childhood emotional and/or physical neglect (NG, N = 30), or unaffected comparison women (HC, N = 40). They completed a previously validated rewarded (color-word) Stroop task and filled out questionnaires on depression, anxiety, and resilience. Results: Surprisingly, a significant group by reward interaction revealed larger performance benefits under reward prospect (relative to no-reward) for the AG group relative to both the NG and HC groups. Limitations: A small sample size limiting generalizability. Conclusions: These results demonstrate sensitivity of abused subjects to reward in modulating cognitive control and might aid in discussing whether using reward schedules during therapeutic interventions could be effective.

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Section: Tablementioning

confidence: 81%

Section: Introductionmentioning

confidence: 99%

Reward prospect improves inhibitory control in female university students with a history of childhood sexual and physical abuse

Kiyar¹,

Lommen²,

Krebs³

et al. 2021

Journal of Behavior Therapy and Experimental Psychiatry

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“…Childhood trauma is a significant risk factor for developing MDD in later life [ 39 ]. In addition, higher intensity of childhood trauma was associated with stronger OGM [ 40 , 41 ]. It was verified that childhood abuse predicted greater rumination and impaired executive function and maladaptive emotion regulation, which were causes of OGM [ 42 – 44 ].…”

Section: Discussionmentioning

confidence: 99%

Distinct effects of over-general autobiographical memory on suicidal ideation among depressed and healthy people

Jiang

Zhang

et al. 2020

BMC Psychiatry

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Background Childhood trauma and over-general autobiographical memory (OGM) are crucial risk factors of suicide. This study aimed to investigate whether suicidal ideation was predicted by one’s childhood trauma and OGM and the mechanism of OGM underlying suicidal ideation in depression patients and healthy controls. Methods A total of 180 depression patients and 176 matched healthy individuals were recruited in this study. Data were analyzed using descriptive statistics, and Pearson’s correlation coefficient was obtained. Path analysis was conducted to test a meditational model. The multigroup comparison was applied to find differences between groups. Results Significant differences were detected between depression patients and healthy controls with respect to childhood trauma, OGM, suicidal ideation, and suicidal behavior. OGM was positively correlated with both current and worst-point suicidal ideation in the depression group and significantly correlated with worst-point suicidal ideation in the healthy control group. The path model showed that childhood trauma had a direct impact on the current suicidal ideation directly, and an indirect influence through OGM and worst-point suicidal ideation. Multigroup analysis further demonstrated that OGM affected and mediated the current suicidal ideation due to childhood trauma in depression patients, whereas only worst-point suicidal ideation was affected in healthy controls. Conclusions The OGM mediates suicidal ideation in depression patients, but only affects the worst-point suicidal ideation in the healthy controls. As it is one of the major risk factors of suicidal ideation in depression, amelioration of OGM might be an useful method to reduce or prevent suicidal ideation in depression patients.

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“…Coelho et al, 2016 ) or young adults (e.g. Thomsen et al, 2019 ), we opted for adult women in order to extend the literature in this population, since ACE has repeatedly been associated with mental impairments and disorders in later life (Gould et al, 2012 ; Kaczmarczyk, Wingenfeld, Kuehl, Otte, & Hinkelmann, 2018 ; Majer, Nater, Lin, Capuron, & Reeves, 2010 ; Pechtel & Pizzagalli, 2011 ). We hypothesized that plasma levels of copeptin would be positively correlated with MDD and ACE.…”

Section: Introductionmentioning

confidence: 99%

No association between major depression with and without childhood adversity and the stress hormone copeptin

Kaczmarczyk

Spitzer

Wingenfeld

et al. 2020

European Journal of Psychotraumatology

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Background: Adverse childhood experiences (ACE) are associated with an increased risk of major depressive disorder (MDD) and hypothalamic-pituitary-adrenal (HPA) axis dysregulation. Within the HPA axis, corticotropin-releasing hormone and vasopressin (AVP) synergistically stimulate the release of adrenocorticotropic hormone, which promotes cortisol release. The cleavage product copeptin is produced during AVP synthesis and is a surrogate marker of AVP release. Children with ACE and young adults with depressive symptoms have higher levels of copeptin than healthy controls. Objective: To uncover the effects of MDD and ACE on copeptin levels in adult females. Methods: We recruited 94 women (mean age: 34.0 ± 3.6 years): 23 with MDD and ACE, 24 with MDD without ACE, 22 with ACE without MDD, and 25 healthy controls. ACE was defined as repeated sexual or physical abuse at least once a month over at least one year before the age of 18 years. MDD was defined by the DSM-IV criteria. Copeptin plasma levels were measured with an immunoluminometric assay. Results: The four groups did not differ in demographic variables. We found a significant negative correlation between body mass index (BMI) and copeptin plasma levels (r = −.21; p = .045). Copeptin plasma levels did not differ between the four groups after controlling for BMI. Conclusion: Neither MDD nor ACE was associated with altered plasma copeptin levels. Thus, copeptin does not seem to play a major role in MDD and ACE in adult females.

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Childhood trauma and diagnosis of major depression: Association with memory and executive function

Cited by 32 publications

References 47 publications

Reward prospect improves inhibitory control in female university students with a history of childhood sexual and physical abuse

Reward prospect improves inhibitory control in female university students with a history of childhood sexual and physical abuse

Distinct effects of over-general autobiographical memory on suicidal ideation among depressed and healthy people

No association between major depression with and without childhood adversity and the stress hormone copeptin

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