Childhood trauma and treatment outcomes during mood‐stabilising treatment with lithium or quetiapine among outpatients with bipolar disorder

Wrobel, Anna L; Köhler‐Forsberg, Ole; Sylvia, Louisa G.; Russell, Scott C.; Dean, Olivia; Cotton, Sue; Thase, Michael E.; Calabrese, Joseph R.; Deckersbach, Thilo; Tohen, Mauricio; Bowden, Charles L.; McInnis, Melvin G.; Kocsis, James H.; Friedman, Edward S.; Ketter, Terence A.; Shelton, Richard C.; Ostacher, Michael J.; Iosifescu, Dan V.; Berk, Michael; Turner, Alyna; Nierenberg, Andrew A.

doi:10.1111/acps.13420

Cited by 13 publications

(8 citation statements)

References 55 publications

(99 reference statements)

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“…Elmer et al [ 196 ] reported that ketamine metabolite (2R,6R)-hydroxynorketamine reversed behavioral despair produced by adolescent trauma. Furthermore, recently, Wrobel et al [ 197 ] examined the role of childhood trauma in treating bipolar disorder. The effect of childhood trauma on treatment outcomes was evaluated among participants randomized to treatment with lithium or quetiapine.…”

Section: Discussionmentioning

confidence: 99%

Dissecting early life stress-induced adolescent depression through epigenomic approach

Ochi

Dwivedi

2022

Mol Psychiatry

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Early life stress (ELS), such as abuse and neglect during childhood, can lead to psychiatric disorders in later life. Previous studies have suggested that ELS can cause profound changes in gene expression through epigenetic mechanisms, which can lead to psychiatric disorders in adulthood; however, studies on epigenetic modifications associated with ELS and psychiatric disorders in adolescents are limited. Moreover, how these epigenetic modifications can lead to psychiatric disorders in adolescents is not fully understood. Commonly, DNA methylation, histone modification, and the regulation of noncoding RNAs have been attributed to the reprogramming of epigenetic profiling associated with ELS. Although only a few studies have attempted to examine epigenetic modifications in adolescents with ELS, existing evidence suggests that there are commonalities and differences in epigenetic profiling between adolescents and adults. In addition, epigenetic modifications are sex-dependent and are influenced by the type of ELS. In this review, we have critically evaluated the current evidence on epigenetic modifications in adolescents with ELS, particularly DNA methylation and the expression of microRNAs in both preclinical models and humans. We have also clarified the impact of ELS on psychiatric disorders in adolescents to predict the development of neuropsychiatric disorders and to prevent and recover these disorders through personalized medicine.

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Section: Discussionmentioning

confidence: 99%

Dissecting early life stress-induced adolescent depression through epigenomic approach

Ochi

Dwivedi

2022

Mol Psychiatry

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“…Individuals with BD who have a history of childhood trauma report more depressive episodes and experience more severe depressive symptoms, than individuals without a history of childhood trauma 6,17 . Interestingly, in other clinical populations (e.g., major depressive disorder) associations between childhood trauma and the experience of specific domains of depressive symptoms have also been highlighted 18–20 .…”

Section: Introductionmentioning

confidence: 99%

Childhood trauma and depressive symptoms in bipolar disorder: A network analysis

Wrobel

Cotton

Jayasinghe

et al. 2023

Acta Psychiatr Scand

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Background Childhood trauma is related to an increased number of depressive episodes and more severe depressive symptoms in bipolar disorder. The evaluation of the networks of depressive symptoms—or the patterns of relationships between individual symptoms—among people with bipolar disorder with and without a history of childhood trauma may assist in further clarifying this complex relationship. Methods Data from over 500 participants from the Heinz C. Prechter Longitudinal Study of Bipolar Disorder were used to construct a series of regularised Gaussian Graphical Models. The networks of individual depressive symptoms—self‐reported (Patient Health Questionnaire—9; n = 543) and clinician‐rated (Hamilton Depression Rating Scale—17; n = 529)—among participants with bipolar disorder with and without a history of childhood trauma (Childhood Trauma Questionnaire) were characterised and compared. Results Across the sets of networks, depressed mood consistently emerged as a central symptom (as indicated by strength centrality and expected influence); regardless of participants' history of childhood trauma. Additionally, feelings of worthlessness emerged as a key symptom in the network of self‐reported depressive symptoms among participants with—but not without—a history of childhood trauma. Conclusion The present analyses—although exploratory—provide nuanced insights into the impact of childhood trauma on the presentation of depressive symptoms in bipolar disorder, which have the potential to aid detection and inform targeted intervention development.

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“…Early-life stress, including childhood trauma, can disturb the development of the brain and thus increase the risk of mental illness [ 8 ]. It was found that BD patients with childhood trauma showed greater symptom severity [ 9 ], and increased risk of nonsuicidal self-injury [ 10 ]. Wrobel et al reported that depressive symptoms in BD patients were positively associated with childhood trauma [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

Association of childhood trauma, social support, cognition, and suicidality in females with bipolar disorder

Yang,

Li,

et al. 2024

BMC Psychiatry

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Background Bipolar disorder (BD) is a severe mental disorder with heavy disease burden. Females with BD are special populations who suffer a lot from childhood trauma, social support, cognitive deficits, and suicidality. In this study, the relationship among childhood trauma, social support, and clinical symptoms of BD was investigated and the risk factors for suicidality were explored in female patients with BD. Methods This study included 57 drug-naive female BD patients, 64 female BD patients with long-term medication, and 50 age-matched female healthy controls. Childhood trauma, social support, clinical symptoms, cognition, and suicidality (suicide ideation, suicide plan, suicide attempt, suicide frequency) were measured with scales. Results Compared with healthy controls, females with BD showed higher levels of childhood trauma and suicidality, and lower levels of social support and cognitive deficits. In the drug-naïve BD group, social support mediated the relationship between childhood trauma and insomnia symptoms (indirect effect: ab = 0.025). In the BD with long-term medication group, mania symptom was associated with suicide plan (OR = 1.127, p = 0.030), childhood trauma was associated with suicide attempt (OR = 1.088, p = 0.018), and years of education (OR = 0.773, p = 0.028), childhood trauma (OR = 1.059, p = 0.009), and delayed memory (OR= 1.091, p= 0.016) was associated with suicide frequency (OR = 1.091, p = 0.016). Conclusions This study provides initial evidence that social support partially explains the relationship between childhood trauma and clinical symptoms in females with BD. Additionally, mania symptoms, childhood trauma, and delayed memory were risk factors for suicidality. Interventions providing social support and improving cognitive function may be beneficial for females with BD who are exposed to childhood trauma and with high suicide risk.

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Childhood trauma and treatment outcomes during mood‐stabilising treatment with lithium or quetiapine among outpatients with bipolar disorder

Cited by 13 publications

References 55 publications

Dissecting early life stress-induced adolescent depression through epigenomic approach

Dissecting early life stress-induced adolescent depression through epigenomic approach

Childhood trauma and depressive symptoms in bipolar disorder: A network analysis

Association of childhood trauma, social support, cognition, and suicidality in females with bipolar disorder

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