Childhood trauma is linked to abnormal static-dynamic brain topology in adolescents with major depressive disorder

Li, Xuemei; Huang, Yang; Liu, Mengqi; Zhang, Manqi; Liu, Yang; Teng, Teng; Liu, Xueer; Yu, Ying; Jiang, Yuanliang; Ouyang, Xuan; Xu, Ming; Lv, Fajin; Long, Yicheng

doi:10.1016/j.ijchp.2023.100401

Cited by 7 publications

(1 citation statement)

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“…We also calculated the cumulative risk of childhood trauma and referred it as the childhood trauma index (CTI), in line with prior studies [ 20 , 22 , 43 ]. The CTI reflected the cumulative number of moderate or severe trauma types, according to guidelines from the CTQ manual [ 44 ] and previous studies [ 45 – 47 ]. Specifically, participants who met the following criteria for each subtype were considered to have experienced the corresponding subtype of childhood trauma: emotional abuse score ≥ 13, physical abuse score ≥ 10, sexual abuse score ≥ 8, emotional neglect score ≥ 15, or physical neglect score ≥ 10.…”

Section: Methodsmentioning

confidence: 99%

Self-concept mediates the relationships between childhood traumatic experiences and adolescent depression in both clinical and community samples

Hu,

Yang,

et al. 2024

BMC Psychiatry

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Background Childhood trauma is a pivotal risk factor for adolescent depression. While the association between childhood trauma and depression is well-established, the mediating role of self-concept has not been acknowledged. Specifically, limited attention has been paid to how childhood maltreatment impacts adolescent depression through physical and social self-concept, both in clinical and community samples. This study aims to investigate how distinct and cumulative childhood trauma affects adolescent depression, as well as the potential mediating role of self-concept in their relationships. Methods We recruited 227 depressed adolescents (dataset 1, 45 males, age = 15.34 ± 1.96) and 574 community adolescents (dataset 2, 107 males, age = 16.79 ± 0.65). Each participant was assessed on five subtypes of childhood trauma severity, cumulative trauma index, physical and social self-concept, and depression. Mediation models were tested separately in the clinical and community samples. Results Clinically depressed adolescents experienced a higher level of trauma severity, a greater number of trauma subtypes, and had lower levels of physical and social self-concept compared to community adolescents. Analyses on childhood trauma severity and cumulative trauma index jointly indicated that physical and social self-concept played mediation roles in the relationships between childhood trauma experiences and depression. Moreover, the mediating effects of self-concept were stronger in depressed adolescents when compared to community samples. Conclusions Our findings suggest that physical and social self-concept play mediating roles in the pathway linking childhood trauma and adolescent depression, particularly in clinically depressed individuals.

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