Childhood trauma, perceived stress, and hair cortisol in adults with and without coronary artery disease

Bossé, Stéphanie; Masciotra, Viviane; Solomon, Crina; Stalder, Tobias; DʼAntono, Bianca

doi:10.1016/j.psyneuen.2015.07.488

Cited by 6 publications

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“…Prior studies reported a negative association between CM and hair cortisol [ 22 , 23 ]. However, our results are in line with another study reporting no such association [ 50 ]. However, none of these studies investigated steroids during pregnancy.…”

Section: Discussionsupporting

confidence: 93%

Alterations of hair cortisol and dehydroepiandrosterone in mother-infant-dyads with maternal childhood maltreatment

et al. 2017

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BackgroundChild maltreatment (CM) has severe effects on psychological and physical health. The hypothalamic-pituitary-adrenal (HPA) axis, the major stress system of the body, is dysregulated after CM. The analysis of cortisol and dehydroepiandrosterone (DHEA) in scalp hair presents a new and promising methodological approach to assess chronic HPA axis activity. This study investigated the effects of CM on HPA axis activity in the last trimester of pregnancy by measuring the two important signaling molecules, cortisol and DHEA in hair, shortly after parturition. In addition, we explored potential effects of maternal CM on her offspring’s endocrine milieu during pregnancy by measuring cortisol and DHEA in newborns’ hair.MethodsCM was assessed with the Childhood Trauma Questionnaire (CTQ). Cortisol and DHEA were measured in hair samples of 94 mothers and 30 newborns, collected within six days after delivery. Associations of maternal CM on her own and her newborn’s cortisol as well as DHEA concentrations in hair were analyzed with heteroscedastic regression models.ResultsHigher CM was associated with significantly higher DHEA levels, but not cortisol concentrations in maternal hair. Moreover, maternal CM was positively, but only as a non-significant trend, associated with higher DHEA levels in the newborns’ hair.ConclusionsResults suggest that the steroid milieu of the mother, at least on the level of DHEA, is altered after CM, possibly leading to non-genomic transgenerational effects on the developing fetus in utero. Indeed, we observed on an explorative level first hints that the endocrine milieu for the developing child might be altered in CM mothers. These results need extension and replication in future studies. The measurement of hair steroids in mothers and their newborns is promising, but more research is needed to better understand the effects of a maternal history of CM on the developing fetus.Electronic supplementary materialThe online version of this article (doi:10.1186/s12888-017-1367-2) contains supplementary material, which is available to authorized users.

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Section: Discussionsupporting

confidence: 93%

Alterations of hair cortisol and dehydroepiandrosterone in mother-infant-dyads with maternal childhood maltreatment

et al. 2017

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“…Thus, once these findings have been confirmed in larger samples, a next step could be to examine whether the elevated HCCs in aSAH survivors are attributable to ACTH dependent or ACTH independent sources [37]. Nevertheless, the elevated HCCs in aSAH patients are critical as increased HCCs have been shown to constitute a risk factor for cardiovascular diseases [38], diabetes mellitus [39], increased BMI and obesity [40], and the occurrence of metabolic syndrome [41]. Finally, as reported in a previous paper [16], aSAH patients reported significantly higher depressive symptoms, hypochondriacal beliefs, and sleep complaints than healthy controls.…”

Section: Discussionmentioning

confidence: 99%

In Individuals Following Aneurysmal Subarachnoid Haemorrhage, Hair Cortisol Concentrations Are Higher and More Strongly Associated with Psychological Functioning and Sleep Complaints than in Healthy Controls

Colledge

Brand²,

Zimmerer³

et al. 2017

Neuropsychobiology

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Background: Following an aneurysmal subarachnoid haemorrhage (aSAH), many patients report persistent deficits in psychological functioning, characterised by high levels of stress and symptoms of depression, low life satisfaction, along with poor sleep. Such deficits have been associated with altered saliva and serum cortisol levels due to a dysregulation of hypothalamic-pituitary-adrenal axis activity (HPA-AA). However, hair cortisol concentrations (HCCs) have not been assessed in this population, although this method allows a long-term insight into cortisol values. Therefore, the objective of this study was to compare HCCs in aSAH patients and healthy controls and to examine how HCCs are associated with perceived stress, psychological functioning, and sleep complaints. Methods: In this cross-sectional study, data on depressive symptoms, hypochondriacal beliefs, life satisfaction, and sleep complaints were gathered in 15 aSAH patients and 17 healthy controls. HCCs of the previous 3 months were assessed. Results: aSAH patients had significantly higher HCCs than healthy controls. In aSAH patients, higher HCCs were significantly associated with increased depressive symptoms, hypochondriacal beliefs, lower life satisfaction, and increased sleep complaints. Such significant associations were not found in healthy controls. Conclusions: Our findings indicate that a dysregulation of HPA-AA is associated with some of the long-term impairments in psychological functioning and sleep in aSAH survivors. While the direction of association remained unclear, a dysregulated HPA-AA may be causally linked with the maintenance of poor psychological functioning and poor sleep. The overall findings should be considered in the planning of long-term treatment aimed at improving psychological functioning and sleep in aSAH patients.

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“…Neuroticism also tends to be inversely associated with cognitive ability [ 24 – 26 ], and the aspects of neuroticism associated with proneness to distress have been found to be associated with increased cognitive decline [ 27 ]. Similarly, early life events and circumstances may also confound the association of stress with cognitive function, as adverse childhood circumstances, such as poverty, are associated both with poorer cognitive function [ 28 , 29 ] and perceived stress later in life [ 30 ]. Finally, compared to studies on patient groups, there are fewer studies based on the general population.…”

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confidence: 99%

Midlife perceived stress is associated with cognitive decline across three decades

et al. 2023

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Background Research indicates detrimental effects of stress on brain health and cognitive functioning, but population-based studies using comprehensive measures of cognitive decline is lacking. The present study examined the association of midlife perceived stress with cognitive decline from young adulthood to late midlife, controlling for early life circumstances, education and trait stress (neuroticism). Methods The sample consisted of 292 members of the Copenhagen Perinatal Cohort (1959–1961) with continued participation in two subsequent follow-up studies. Cognitive ability was assessed in young adulthood (mean age 27 years) and midlife (mean age 56 years) using the full Wechsler Adult Intelligence Scale (WAIS), and perceived stress was measured at midlife using the Perceived Stress Scale. The association of midlife perceived stress with decline in Verbal, Performance and Full-Scale IQ was assessed in multiple regression models based on Full Information Maximum Likelihood estimation. Results Over a mean retest interval of 29 years, average decline in IQ score was 2.42 (SD 7.98) in Verbal IQ and 8.87 (SD 9.37) in Performance IQ. Mean decline in Full-scale IQ was 5.63 (SD 7.48), with a retest correlation of 0.83. Controlling for parental socio-economic position, education and young adult IQ, higher perceived stress at midlife was significantly associated with greater decline in Verbal (β = − 0.012), Performance (β = − 0.025), and Full-scale IQ (β = − 0.021), all p < .05. Across IQ scales, additionally controlling for neuroticism in young adulthood and change in neuroticism had only minor effects on the association of midlife perceived stress with decline. Conclusions Despite very high retest correlations, decline was observed on all WAIS IQ scales. In fully adjusted models, higher midlife perceived stress was associated with greater decline on all scales, indicating a negative association of stress with cognitive ability. The association was strongest for Performance and Full-scale IQ, perhaps reflecting the greater decline on these IQ scales compared to Verbal IQ.

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Childhood trauma, perceived stress, and hair cortisol in adults with and without coronary artery disease

Cited by 6 publications

References 0 publications

Alterations of hair cortisol and dehydroepiandrosterone in mother-infant-dyads with maternal childhood maltreatment

Alterations of hair cortisol and dehydroepiandrosterone in mother-infant-dyads with maternal childhood maltreatment

In Individuals Following Aneurysmal Subarachnoid Haemorrhage, Hair Cortisol Concentrations Are Higher and More Strongly Associated with Psychological Functioning and Sleep Complaints than in Healthy Controls

Midlife perceived stress is associated with cognitive decline across three decades

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