Childhood Tumors of the Brain: Demographic Pattern over a Ten-Year Period in the Kashmir Valley

Nayil, Khursheed; Makhdoomi, Rumana; Ramzan, Altaf; Zahoor, Sheikh; Rasool, Mohsin; Wani, Abrar Ahad; Dhar, Anil; Mubeen, Basharat; Singh, Sarbjit; Bhat, Rashid Manzoor; Kirmani, Altaf Rehman

doi:10.1159/000327143

Cited by 9 publications

(12 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Consistent with the vast majority of international studies [11,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30], a slight male predominance of childhood intracranial tumors (M/F = 1.04) was noted in our Egyptian referral center. In this context, Rickert and Paulus [5], in their meta-analysis of 10,582 childhood brain tumors accumulated from 16 international surveys, reported that the M/F ratio was 1.29.…”

Section: Discussionsupporting

confidence: 91%

“…Consistent with the slight IT preponderance seen in the present study (ST/IT = 216/233 = ratio of 0.94), many authors have reported a slight predominance of IT region tumors compared to those of the ST compartment (Sweden, Denmark, Kashmir, Pakistan, Syria, South Africa, USA and Barbados) [11,15,22,23,24,29,30,32]. This includes the meta-analysis of 16 international studies where the ST/IT ratio was 0.92 [5].…”

Section: Discussionsupporting

confidence: 91%

“…Regarding the most common pediatric intracranial tumor, the vast majority of studies [5,11,12,14,15,16,17,20,21,22,25,26,27,28,29,30,32,37] have reported that astrocytomas followed by medulloblastomas are the 2 most common intracranial tumors during childhood. However, two hospital-based Pakistani and Syrian studies reported medulloblastomas to be the most common pediatric intracranial tumors ahead of astrocytomas [23,24].…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Descriptive Epidemiology of Pediatric Intracranial Neoplasms in Egypt

El-Gaidi

2011

Pediatr Neurosurg

View full text Add to dashboard Cite

Objective: The characteristics of 451 Egyptian children (aged 0–14 years) with primary intracranial neoplasms were investigated for demographic, clinical, topographical and pathological features using the most recent 2007 Classification of Central Nervous System Tumors. Patients and Methods: This was a retrospective study performed in the Departments of Pediatric Neurosurgery of the Cairo University Hospitals from 2005 to 2008. Results: There was a slight male predominance (51.4%) observed in our study, and the most affected age group was 5–9 years old (43.2%). Most of the tumors were confined to a single compartment (infratentorial in 49.7%, supratentorial in 46.6%), while 3.8% of the tumors involved multiple compartments. The most common intracranial tumors were astrocytomas (35%), medulloblastomas (18.8%), craniopharyngiomas (11.3%) and ependymomas (10%). Pilocytic astrocytomas constituted 55% of all astrocytomas and 19.3% of all brain tumors, only slightly ahead of medulloblastomas. Less common types were primitive neuroectodermal tumors (2.7%), followed by meningiomas, germ cell tumors and choroid plexus tumors (2.4% each). According to the International Classification of Diseases for Oncology Coding (ICD-O-4), benign, borderline and malignant tumors constituted 7.54, 36.14 and 56.32%, respectively. Conclusion: The characteristics of pediatric intracranial tumors in Egypt are generally similar to those reported in the literature, with only minor differences.

show abstract

Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Descriptive Epidemiology of Pediatric Intracranial Neoplasms in Egypt

El-Gaidi

2011

Pediatr Neurosurg

View full text Add to dashboard Cite

show abstract

“…This is consistent with national and international studies reporting a slight male predominance [8] [9]. In similar national studies, males constituted (57%) in previous NCI study [10], and (51.4%) in a larger Kasr Al Aini study [11].…”

Section: Demographic Datasupporting

confidence: 90%

Treatment Outcome and Prognostic Factors for Pediatric Medulloblastoma Patients: The Egyptian National Cancer Institute Experience

El-Kest¹,

Amin²,

Zaza³

2017

JCT

View full text Add to dashboard Cite

Purpose: To evaluate treatment outcomes and prognostic factors of pediatric Medulloblastoma (MB) patients treated by adjuvant post-operative riskadapted radiotherapy (RT) and chemotherapy (CT). Patients and Methods:A retrospective analysis was conducted based on medical records of pediatric patients with pathologically confirmed MB treated between 2006 and 2013 at the National cancer Institute (NCI), Egypt. Various patients' and disease characteristics, treatment details and outcome data were reviewed. Results: Fifty patients' records were included in the analysis with a median age of 6 years at diagnosis (range 3 -18). According to the Chang staging system; 38%, 44%, 4%, and 14% were M0, M1, M2, and M3, respectively. All patients underwent primary surgery; gross total resection (with no residual) in 38%, near total resection (with residual ≤1.5 cm 2 ) in 8%, subtotal resection (with residual > 1.5 cm 2 ) in 34%, and 20% had only biopsy. All patients were treated by riskadapted craniospinal irradiation (CSI); high-risk patients were treated by CSI 36 Gy/20 fractions over 4 weeks followed by posterior fossa (PF) boost 18 Gy/10 fractions over 2 weeks (180 cGy per fraction), while standard-risk patients were treated by CSI 23.4 Gy/13 fractions over 2 and half weeks followed by PF boost 30.6 Gy/17 fractions over 3 and half weeks. Median overall treatment time (OTT) was 52 days. All patients received adjuvant CT; 47 patients (94%) received concomitant chemo radiotherapy (CCRT), while 4 patients (8%) only received neoadjuvant CT (NB: only one patient received all neoadjuvant, concomitant and adjuvant CT). With a median follow up time of 32.5 months, ranging from 6 to 104 months, the whole group estimates of the overall survival (OS) at 1, 3, and 5 years were 83%, 70%, and 64%, respectively, while, the progression-free survival (PFS) rates at 1, 3, and 5 years were 79%, 62%, and 57% respectively. Four patients relapsed. Neural-axis was the commonest site of relapse (3 patients). Both risk groups were equally represented in relapsed patients (2 standard risk & 2 high risk patients) and relapse took place within 2 years. In univariate analysis, performance status, 700extent of surgery, and post-operative residual tumor size were significant prognostic factors for OS. On the other hand, factors which affected the PFS included gender, extent of surgery, and post-operative residual tumor. Conclusion: Neural-axis relapse was the commonest site of relapse for pediatric MB patients. Extent of surgical resection, post-operative residual tumor, and gender are powerful prognostic factors. Maximal safe resection is the standard surgical approach for MB patients to achieve cure.

show abstract

“…In this study it was observed that infratentorial brain tumour (64%) were more common in the children than supratentorials (36%). Nayil et al found that 44.75% were supratentorial and 55.25% were infratentorial 17 . In another study, Ahmed et al showed supratentorial in 33.3% and infratentorial in 66.7% 16 .…”

Section: Discussionmentioning

confidence: 99%

Clinical Profile of Brain Tumour in Children

Sharmin

Begum

Khatoon³

2017

J Shaheed Suhrawardy Med Coll

View full text Add to dashboard Cite

Background: This study was designed to evaluate the clinical profile and location of brain tumours in children so that brain tumour cases could be diagnosed and managed earlier. Materials and Methods: This cross sectional study was carried out from April 2011 to April 2012. A total 50 clinically suspected cases of brain tumour and supported by MRI were enrolled in this study. Results: Brain tumour of children was predominant in male where male to female ratio was almost 1.9:1. Supratentorial and Infratentorial brain tumour were found in 36% and 64% cases respectively in children. According to MRI findings in the supratentorial location, craniopharyngioma were commonest (50%) followed by cerebral astrocytoma (22.2%). In the infratentorial region, medulloblastoma was observed in (40.6%), followed by cerebellar astrocytoma (31.3%). Vertigo, weakness of limbs were found in 46.9% and 87.5% cases respectively in infratentorial group which were significantly (p<0.05) higher than supratentorial group. Growth failure and behavioral change were found in 16.7% and 22.2% cases respectively in supratentorial which were significantly (p<0.05) higher than infratentorial group. Papilloedema, reduced muscle power, increased muscle tone, exaggerated deep reflexes, clonus, gait disturbance and cerebellar signs were significantly (p<0.05) higher in infratentorial group. Conclusion: Craniopharyngioma and medulloblastoma were more common findings in MRI evaluation in the supratentorial and infratentorial location respectively. Growth failure and behavioral change were found higher in supratentorial than infratentorial group. Vertigo, weakness of limbs, papilloedema, reduced muscle power, increased muscle tone, exaggerated deep reflexes, clonus, gait disturbance and cerebellar signs were higher in infratentorial group. [J Shaheed Suhrawardy Med Coll 2016;8(1): 08-12]

show abstract

Childhood Tumors of the Brain: Demographic Pattern over a Ten-Year Period in the Kashmir Valley

Cited by 9 publications

References 38 publications

Descriptive Epidemiology of Pediatric Intracranial Neoplasms in Egypt

Descriptive Epidemiology of Pediatric Intracranial Neoplasms in Egypt

Treatment Outcome and Prognostic Factors for Pediatric Medulloblastoma Patients: The Egyptian National Cancer Institute Experience

Clinical Profile of Brain Tumour in Children

Contact Info

Product

Resources

About