Childhood Uric Acid Predicts Adult Blood Pressure

Alper, Arnold B.; Chen, Wei; Yau, Lillian; Srinivasan, Sathanur R.; Berenson, Gerald S.; Hamm, L. Lee

doi:10.1161/01.hyp.0000150783.79172.bb

Cited by 299 publications

(228 citation statements)

References 21 publications

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“…Regarding the mean age of the individuals in this series (50.3 years), there are no significant differences in relation to most studies on the subject 3,18 , except for the studies carried out in children and adolescents, such as the one by Bogalusa 14 or the trial carried out by Forman et al 26 , in which mean age was 61 years.…”

Section: Discussionmentioning

confidence: 55%

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Associação entre ácido úrico e variáveis de risco cardiovascular em uma população não hospitalar

Barbosa

Brandão²,

Pozzan³

et al. 2011

Arq. Bras. Cardiol.

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Section: Discussionmentioning

confidence: 55%

“…Several studies have demonstrated that UA is an independent risk variable for cardiovascular risk factors [2][3][4][5][13][14][15][16][17][18][19][20][21][22][23][24][25] .…”

Section: Discussionmentioning

confidence: 99%

Associação entre ácido úrico e variáveis de risco cardiovascular em uma população não hospitalar

Barbosa

Brandão²,

Pozzan³

et al. 2011

Arq. Bras. Cardiol.

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“…Recent clinical trials suggest that uric acid has a role in the development of hypertension, at least in adolescents and adolescents with obesity. 11,12 This is supported by epidemiological data, 20 including studies in adult populations. [1][2][3] Our study included only adults with a known diagnosis of hypertension attending a specialist hypertension service.…”

Section: Discussionmentioning

confidence: 73%

Serum Uric Acid Level, Longitudinal Blood Pressure, Renal Function, and Long-Term Mortality in Treated Hypertensive Patients

et al. 2013

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There are a plethora of epidemiological studies linking uric acid with incident hypertension [1][2][3][4] and with cardiovascular events. 5 Some studies have shown a sex difference in cardiovascular events with the adverse cardiovascular association of uric acid seen only in women. [6][7][8] There is convincing evidence from animal studies that elevated uric acid has a detrimental effect on blood pressure (BP) and renal function. Administration of uric acid causes a rise in arterial BP in rat models 9 and sustained elevation of uric acid results in salt-sensitive hypertension and irreversible renal damage characterized by both arteriolar and glomerular damage. 10 Furthermore, the xanthine oxidase inhibitor allopurinol lowers BP in adolescents with hypertension and hyperuricemia 11 and both allopurinol and the uricosuric drug probenecid lower BP in obese adolescents with prehypertension. 12 A recent meta-analysis found that allopurinol lowers BP by 3/2 mm Hg in adults, 13 although this has never been tested in a specifically designed prospective study. Despite these results, there is still debate about a causal role for uric acid and the potential cardiovascular benefits of allopurinol may reflect either uric acid reduction or other mechanisms, such as superoxide anion reduction. 14 The association of uric acid with BP and kidney function suggests that uric acid levels may have implications in the clinical management of hypertension. The aim of this study is to determine whether baseline uric acid level, in patients attending a hypertension clinic, is associated with longitudinal BP level, renal function, and long-term cause-specific mortality in a sex-specific manner. Methods Study Setting and Study PopulationWe performed an analysis of longitudinal BP control, change in renal function, and long-term cause-specific mortality using data from the Glasgow Blood Pressure Clinic (GBPC).Abstract-Uric acid may have a role in the development of hypertension and renal dysfunction. We explored the relationship among longitudinal blood pressure, renal function, and cardiovascular outcomes in a large cohort of patients with treated hypertension. We used data from the Glasgow Blood Pressure Clinic database. Patients with a baseline measure of serum uric acid and longitudinal measures of blood pressure and renal function were included. Mortality data were obtained from the General Register Office for Scotland. Generalized estimating equations were used to explore the relationship among quartiles of serum uric acid, blood pressure, and estimated glomerular filtration rate. Cox proportional hazard models were developed to assess mortality relationships. In total, 6984 patients were included. Serum uric acid level did not influence the longitudinal changes in systolic or diastolic blood pressure but was related to change in glomerular filtration rate. In comparison with patients in the first quartile of serum uric acid, the relative decrease in glomerular filtration rate in the fourth was 10.7 (95% confidence interval, 7.9-13.6 ...

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“…Masuo et al evaluate the linear association of serum uric acid and systolic blood pressure, finding an average increase of 23mm Hg per 1mg/dl increase in serum uric acid among nonobese young men [9]. In an ethnically diverse population within the Bogalusa Heart Study, higher childhood and young adult serum uric acid levels associated with incident hypertension progressive increase in blood pressure within the normal range [10]. A recent re-evaluation of the Framingham Heart Study data also suggests that higher serum uric acid levels is associated with increased risk of progression from normal blood pressure (bp) to hypertension [11].…”

mentioning

confidence: 99%

The Role of Uric Acid in Pediatric Hypertension

Feig

Johnson

2007

Journal of Renal Nutrition

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Over the past few years increasing evidence has supported the possible role of uric acid as a mediator of high blood pressure. Both animal model data and tissue culture experiments suggest that uric acid might cause increased blood pressure by a two phase process. A first phase dominated by a uric acid mediated vasoconstriction followed by induction of renal afferent arteriolosclerosis and altered pressure natriuresis leading to a sodium dependent hypertension. We have assessed children with newly diagnosed essential hypertension and through cross-sectional studies and clinical trials. Elevated uric acid is closely associated with new onset essential hypertension in children and preliminary data suggests that lowering uric acid can lower blood pressure in some patients. Future studies will be needed to determine if the mechanisms shown in animal models can be extrapolated to children.

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Childhood Uric Acid Predicts Adult Blood Pressure

Cited by 299 publications

References 21 publications

Associação entre ácido úrico e variáveis de risco cardiovascular em uma população não hospitalar

Associação entre ácido úrico e variáveis de risco cardiovascular em uma população não hospitalar

Serum Uric Acid Level, Longitudinal Blood Pressure, Renal Function, and Long-Term Mortality in Treated Hypertensive Patients

The Role of Uric Acid in Pediatric Hypertension

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