Childhood urinary organophosphate esters and cognitive abilities in a longitudinal cohort study

Percy, Zana; Chen, Aimin; Yang, Weili; Braun, Joseph M.; Lanphear, Bruce P.; Ospina, María; Calafat, Antònia M.; Xie, Changchung; Cecil, Kim M.; Vuong, Ann M.; Xu, Yingying; Yolton, Kimberly

doi:10.1016/j.envres.2022.114265

Cited by 6 publications

(15 citation statements)

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“…26 The literature on prenatal OPE exposure and child brain development is sparse and has utilized a diverse array of developmental assessment approaches, making it somewhat difficult to synthesize findings. 14,[20][21][22][23][24][25][26][27] The BASC and BRIEF-P are distinct but well-validated rating-based measures of behavior and EF, ). DPhP and DnBP were analyzed using a log10 term and BDCIPP and BBOEP are categorized as <LOD and ≥LOD.…”

Section: Discussionmentioning

confidence: 99%

“…The literature on prenatal OPE exposure and child brain development is sparse and has utilized a diverse array of developmental assessment approaches, making it somewhat difficult to synthesize findings. 14,20–27 The BASC and BRIEF-P are distinct but well-validated rating-based measures of behavior and EF, and there is a high degree of correlation across summary indices. 75 However, differences in OPE associations across studies that utilize different approaches for measuring brain development is not surprising.…”

Section: Discussionmentioning

confidence: 99%

“…14,21 Eight of these nine studies have also evaluated child sex as a potential modifier of the OPE- neurodevelopment relationship, with most of these studies finding some association. 14,21–27 However, observed sex-specific OPE-EF associations has differed in the literature with relation to both OPE and affected sex. 14,21–27…”

Section: Introductionmentioning

confidence: 99%

“…14,21–27 However, observed sex-specific OPE-EF associations has differed in the literature with relation to both OPE and affected sex. 14,21–27…”

Section: Introductionmentioning

confidence: 99%

“…[11][12][13] The human health effects of OPEs are not well understood; however, both animal and human studies have found OPEs may contribute to adverse neurodevelopment. [14][15][16][17][18][19][20][21][22][23][24][25][26][27] Several biological mechanisms have been proposed to explain this relationship, including the potential for OPEs to affect the developing brain directly via developmental toxicity or indirectly through dysregulation of thyroid hormones. [28][29][30] Additionally, OPEs may also operate through sex-specific mechanisms, with female-only dysregulation of thyroid hormones having been observed for two OPEs: tris (1,3-dichloro-2-propyl) phosphate (TCDIPP) and triphenyl phosphate (TPhP).…”

Section: Introductionmentioning

confidence: 99%

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Prenatal organophosphate ester exposure and executive function in Norwegian preschoolers

Hall

Keil

Choi

et al. 2023

Environmental Epidemiology

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Background: Organophosphate esters (OPEs) are ubiquitous chemicals, used as flame retardants and plasticizers. OPE usage has increased over time as a substitute for other controlled compounds. This study investigates the impact of prenatal OPE exposure on executive function (EF) in preschoolers. Methods: We selected 340 preschoolers from the Norwegian Mother, Father, and Child Cohort Study. Diphenyl-phosphate (DPhP), di-n-butyl-phosphate (DnBP), bis(2-butoxyethyl) phosphate (BBOEP), and bis(1,3-dichloro-2-propyl) phosphate (BDCIPP) were measured in maternal urine. EF was measured using the Behavior Rating Inventory of Executive Functioning-Preschool (BRIEF-P) and the Stanford-Binet fifth edition (SB-5). EF scores were scaled so a higher score indicated worse performance. We estimated exposure-outcome associations and evaluated modification by child sex using linear regression. Results: Higher DnBP was associated with lower EF scores across multiple rater-based domains. Higher DPhP and BDCIPP were associated with lower SB-5 verbal working memory (β = 0.49, 95% CI = 0.12, 0.87; β = 0.53, 95% CI = 0.08, 1.02), and higher BBOEP was associated with lower teacher-rated inhibition (β = 0.34, 95% CI = 0.01, 0.63). DPhP was associated with lower parent-reported BRIEF-P measures in boys but not girls [inhibition: boys: 0.37 (95% CI = 0.03, 0.93); girls: –0.48 (95% CI = –1.27, 0.19); emotional control: boys: 0.44 (95% CI = –0.13, 1.26); girls: –0.83 (95% CI = –1.73, –0.00); working memory: boys: 0.49 (95% CI = 0.03, 1.08); girls: –0.40 (95% CI = –1.11, 0.36)]. Fewer sex interactions were observed for DnBP, BBOEP, and BDCIPP, with irregular patterns observed across EF domains. Conclusions: We found some evidence prenatal OPE exposure may impact EF in preschoolers and variation in associations by sex.

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