Childhood vasculitides in Turkey: a nationwide survey

Özen, Seza; Bakkaloğlu, Ayşı̇n; Düşünsel, Ruhan; Söylemezoğlu, Oğuz; Özaltın, Fatih; Poyrazoğlu, Hakan; Kasapçopur, Özgür; Özkaya, Ozan; Yalçınkaya, Fatoş; Balat, Ayşe; Kural, Nurdan; Dönmez, Osman; Alpay, Harika; Anarat, Ali; Mır, Sevgı; Gur-Guven, Ayfer; Sönmez, Ferah; Gök, Faysal

doi:10.1007/s10067-006-0266-6

Cited by 56 publications

(42 citation statements)

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“…Like our study, Gülhan et al (2) were noticed that there was no gender predominance in Turkish children with KD, and they also mentioned that the earlier occurrence of desquamation and cardiovascular disease than expected by conventional teaching. Likewise previous Turkish patient series (1)(2)(3)(4), the most common clinical finding was changes in the lips and oral cavity in our study. We also observed that most of our patients were irritable at the time of the diagnosis.…”

supporting

confidence: 84%

“…Kawasaki disease (KD) has replaced acute rheumatic fever as the most common cause of acquired heart disease in children in developed countries and occurs in 9% of childhood vasculitis in our country (1). There are few studies concerning the characteristic features of Turkish children diagnosed with KD (1)(2)(3)(4).…”

mentioning

confidence: 99%

“…There are few studies concerning the characteristic features of Turkish children diagnosed with KD (1)(2)(3)(4). We aimed to identify the clinical characteristics and potential risk factors for coronary artery abnormalities (CAAs) in Turkish children diagnosed with KD.…”

mentioning

confidence: 99%

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Is there any difference in clinical features of Turkish children with Kawasaki disease?

Ekici¹,

Kocabaş²,

Çetin³

2014

Anadolu Kardiyol Derg

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Kawasaki disease (KD) has replaced acute rheumatic fever as the most common cause of acquired heart disease in children in developed countries and occurs in 9% of childhood vasculitis in our country (1). There are few studies concerning the characteristic features of Turkish children diagnosed with KD (1-4). We aimed to identify the clinical characteristics and potential risk factors for coronary artery abnormalities (CAAs) in Turkish children diagnosed with KD.We evaluated clinical, demographic and laboratory data of 49 patients diagnosed with KD in our Pediatric Cardiology clinic between January 2005 and May 2013, retrospectively. The median age was 27 months and male to female ratio was 1.08 eighteen cases (36.7%) had incomplete presentation. 43 cases were admitted at the acute phase of the disease, they were treated with intravenous immunoglobulin (IVIG) and unresponsiveness to the first dose of IVIG was observed in five cases (11.6%). CAAs were detected in 13 cases (26.5%) by echocardiography. Most cases had mild (6 cases, 46.2%) or moderate (5 cases, 38.5%) size aneurysms and the giant aneurysm occurred in two cases (15.4%). CAAs were detected at the median of 9th day (between 5th and 18th days). CAAs were detected in seven of 13 cases (54%) within the first ten days of febrile illness. CAAs were seen more frequently in patients with incomplete presentation (33.3%) than patients with complete presentation (25%) (p=0.023). The resolution of CAAs was observed in 11 patients within six months, but the giant CAAs didn't resolve in two cases during follow up period. One of them was a 4-month old infant and he had presented with multiple giant coronary aneurysms and massive pericardial effusion. Despite intensive anticoagulation, intramural coronary thrombosis developed in this case and he suddenly died because of myocardial ischemia at the 51 th day. The giant aneurysm was partially regressed in the other case within three years. We identified that the longer time interval from disease onset to treatment (p=0.005), higher platelet counts (p=0.04) and male gender (p=0.02) were the risk factors for coronary abnormalities.In this study, we noticed that a small number of cases with KD was under one year old at admission and there was balanced in gender distribution. These two features were the main clinical differences in our study group. Like our study, Gülhan et al. (2) were noticed that there was no gender predominance in Turkish children with KD, and they also mentioned that the earlier occurrence of desquamation and cardiovascular disease than expected by conventional teaching. Likewise previous Turkish patient series (1-4), the most common clinical finding was changes in the lips and oral cavity in our study. We also observed that most of our patients were irritable at the time of the diagnosis.The other important feature of the Turkish children with KD was a relatively high rate of coronary artery abnormalities which occurs in up to 44.2% of patient series (1-5). Approximately, 10-33% of cases with KD have i...

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confidence: 99%

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Is there any difference in clinical features of Turkish children with Kawasaki disease?

Ekici¹,

Kocabaş²,

Çetin³

2014

Anadolu Kardiyol Derg

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“…Fatigue has been reported as the most common presentation of TA in children, and other signs and symptoms are hypertension (83%), headache (31%), weight loss (22%), arthritis/arthralgia (14%) and fever (2%) (1)(2)(3)(4)(5). Both of our patients had fatigue, hypertension, weight loss and headache.…”

Section: Discussionmentioning

confidence: 99%

“…If untreated, the next phase affects the aorta and its main branches so that affected vessels may become stenotic and aneurysms may develop (2,3). Presenting symptoms at the second stage usually reflect end-organ ischemia with cold extremities, poor or absent of arterial pulses and claudication (2).…”

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A Rare Vasculitis of Childhood, Takayasu Arteritis

et al. 2013

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Kutane Vaskulitiden

Schäkel

Meurer

2008

Hautarzt

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Vasculitis is characterized by an inflammatory reaction of vessel walls with damage to the dependent tissues. Forms of vasculitis which frequently have skin changes include leukocytoclastic angiitis (LcV), Henoch-Schönlein purpura (HSP), cutaneous polyarteriitis nodosum (cPAN), erythema elevatum et diutinum (EED) and urticarial vasculitis (UV). In other forms of vasculitis, systemic manifestations predominate but there are a variety of skin changes. Kawasaki disease (MK), cryoglobulinemic vasculitis (kV), Wegener granulomatosis (WG), Churg-Strauss syndrome (CSS) and microscopic polyangitis (MPA) belong to this group. The causes of vasculitis are heterogeneous. Triggers include infections, drugs, collagen vascular diseases, autoimmune diseases and lymphoproliferative disorders. Idiopathic vasculitis, particularly LcV and EED, occur only once and have a self-limited course. The diagnostic work up depends on the clinical picture and includes inflammatory markers, circulating immune complexes, different types of cryoglobulins and anti-neutrophilic cytoplasmic antibodies, collagen vascular disease specific autoantibodies and additional hematological studies. Vasculitis can manifest in many organs and requires a thorough work up specifically in cases where WG, MPA, CSS and PAN are under consideration.

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Childhood vasculitides in Turkey: a nationwide survey

Abstract: This is the largest multicenter study defining the demographic data for childhood vasculitides. The distribution of childhood vasculitides was different in our population where KD is much less frequent, whereas HSP constitutes an overwhelming majority. C-PAN was more frequent as well.

Cited by 56 publications

References 14 publications

Is there any difference in clinical features of Turkish children with Kawasaki disease?

Is there any difference in clinical features of Turkish children with Kawasaki disease?

A Rare Vasculitis of Childhood, Takayasu Arteritis

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