Childhood viral infections may be beneficial to cognition in old age

Kodesh, Arad

doi:10.1017/s1041610220001477

Int. Psychogeriatr.

2021

DOI: 10.1017/s1041610220001477

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Childhood viral infections may be beneficial to cognition in old age

Arad Kodesh

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2024

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Exposures and conditions prior to age 16 are associated with dementia status among adults in the United States Health and Retirement Study

Cockell,

Wang,

Benke

et al. 2024

Preprint

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Background: Dementia susceptibility likely begins years before symptoms. Early life has not been comprehensively tested for dementia associations. Method: In the US Health and Retirement Study (normal baseline cognition; n=16,509; 2008-2018 waves), 31 exposures before age 16 were retrospectively assessed with ten-year incident cognitive status (dementia, impaired, normal). Using parallel logistic models, each exposure was tested with incident cognition, adjusting for sex, baseline age, follow-up, race/ethnicity, personal/parental education. Result: 14.5% had incident impairment and 5.3% had dementia. Depression was associated with 1.71 (95%CI:1.28,2.26) times higher odds of incident impairment, relative to normal cognition. Headaches/migraines were associated with 1.63 (95%CI:1.18,2.22) times higher odds of incident impairment. Learning problems were associated with 1.75 (95%CI:1.05,2.79) times higher odds of incident impairment. Childhood self-rated health of fair (1.86, 95%CI:1.27,2.64) and poor (3.39, 95%CI:1.91,5.82) were associated with higher incident dementia odds, relative to excellent. Conclusion: Early life factors may be important for impairment or dementia, extending the relevant risk window.

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Exposures and conditions prior to age 16 are associated with dementia status among adults in the United States Health and Retirement Study

Cockell,

Wang,

Benke

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

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Childhood viral infections may be beneficial to cognition in old age

Cited by 1 publication

References 11 publications

Exposures and conditions prior to age 16 are associated with dementia status among adults in the United States Health and Retirement Study

Exposures and conditions prior to age 16 are associated with dementia status among adults in the United States Health and Retirement Study

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